ID   A0A1I7U8K5_9PELO        Unreviewed;       755 AA.
AC   A0A1I7U8K5;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=AMP deaminase {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
DE            EC=3.5.4.6 {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
OS   Caenorhabditis tropicalis.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=1561998 {ECO:0000313|Proteomes:UP000095282, ECO:0000313|WBParaSite:Csp11.Scaffold629.g15952.t1};
RN   [1] {ECO:0000313|WBParaSite:Csp11.Scaffold629.g15952.t1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=AMP + H(+) + H2O = IMP + NH4(+); Xref=Rhea:RHEA:14777,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:58053, ChEBI:CHEBI:456215; EC=3.5.4.6;
CC         Evidence={ECO:0000256|PIRNR:PIRNR001251};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|PIRNR:PIRNR001251};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC       from AMP: step 1/1. {ECO:0000256|ARBA:ARBA00004955}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676,
CC       ECO:0000256|PIRNR:PIRNR001251}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A1I7U8K5; -.
DR   STRING; 1561998.A0A1I7U8K5; -.
DR   WBParaSite; Csp11.Scaffold629.g15952.t1; Csp11.Scaffold629.g15952.t1; Csp11.Scaffold629.g15952.
DR   UniPathway; UPA00591; UER00663.
DR   Proteomes; UP000095282; Unplaced.
DR   GO; GO:0003876; F:AMP deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0032264; P:IMP salvage; IEA:UniProtKB-UniPathway.
DR   CDD; cd01319; AMPD; 1.
DR   Gene3D; 4.10.800.20; -; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR006329; AMPD.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01429; AMP_deaminase; 1.
DR   PANTHER; PTHR11359; AMP DEAMINASE; 1.
DR   PANTHER; PTHR11359:SF0; AMP DEAMINASE; 1.
DR   Pfam; PF19326; AMP_deaminase; 1.
DR   PIRSF; PIRSF001251; AMP_deaminase_met; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR001251};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR001251}.
SQ   SEQUENCE   755 AA;  87452 MW;  A04563E8DFA63F36 CRC64;
     MLQKLRLVRT NIVIRDKTVD SELFDSGPFK KNYAMGHSDH STASPFEIST TPIEVNESRN
     HRTIEISNRA RLESQNDGCL SPSSLKSVLD EIQMEPRSKS PQLVDLHTFR DAVDVNYQRM
     AITGEELSGV PLEDLKTASG HLIEALHLRS KYMERIGNQF PSTTRNFLSG HYPNNLPKHR
     VKNTETTVQT SFNPPDPPKD HWGKNDPLPK YDKIYKFKRN RGVIEICNED GSIDEQFKNI
     YVTKEEFLND TEKLTAMIVD GPLKSFCFRR LSYLENKFQL HVLLNELREL HEQKGVSHRD
     FYNIRKVDTH IHAASSMNQK HLLRFIKKKI KTEADTVVLE NKGTKVTMKE VFKKMGIDAY
     DLSVDMLDVH ADRNTFHRFD KFNTKYNPVG ESTLREIFIK TDNYVGGKYF ADLLKEVLSD
     LEDSKYQHAE PRLSIYGRDK VEWDHLAKWA INHDVWSPNV RWLVQIPRLY DVYRAKNMLK
     SFDDMLDNLF TPLFEVTNDP SSHPELHLFL QQVSGIDSVD DESKHEFVHF DRSTPCPPEF
     TDLENPPYNY YLFYMYANIC ALNALRRARG LNTFALRPHC GEAGHVSHLL TGYLTSESIA
     HGILLRKVPV LQYLYYLTQI GIAMSPLSNN SLFISYQRNP LPEYLQKGLN VSLSTDDPLQ
     FHYTKEALME EYSIAAQVWK LSSCDMCELA RNSVMQSGFE DKVKIHWLGP NYKEEGVLGN
     DIHRTNVPDI RVSFRHEALV DELYNLFRVQ NTLKQ
//