ID A0A1I7UJI4_9PELO Unreviewed; 479 AA.
AC A0A1I7UJI4;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Metal transporter {ECO:0000256|RuleBase:RU369091};
OS Caenorhabditis tropicalis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=1561998 {ECO:0000313|Proteomes:UP000095282, ECO:0000313|WBParaSite:Csp11.Scaffold629.g9957.t1};
RN [1] {ECO:0000313|WBParaSite:Csp11.Scaffold629.g9957.t1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- FUNCTION: Metal transporter. {ECO:0000256|RuleBase:RU369091}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU369091};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU369091}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ACDP family. {ECO:0000256|ARBA:ARBA00010484,
CC ECO:0000256|RuleBase:RU369091}.
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DR AlphaFoldDB; A0A1I7UJI4; -.
DR STRING; 1561998.A0A1I7UJI4; -.
DR WBParaSite; Csp11.Scaffold629.g9957.t1; Csp11.Scaffold629.g9957.t1; Csp11.Scaffold629.g9957.
DR eggNOG; KOG2118; Eukaryota.
DR Proteomes; UP000095282; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008340; P:determination of adult lifespan; IEA:UniProt.
DR GO; GO:0010960; P:magnesium ion homeostasis; IEA:InterPro.
DR GO; GO:1905941; P:positive regulation of gonad development; IEA:UniProt.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR045095; ACDP.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1.
DR PANTHER; PTHR12064:SF4; METAL TRANSPORTER CNNM-4; 1.
DR Pfam; PF01595; CNNM; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR PROSITE; PS51371; CBS; 1.
DR PROSITE; PS51846; CNNM; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU01193}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU01193};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU01193}.
FT TRANSMEM 110..134
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369091"
FT TRANSMEM 170..192
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369091"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369091"
FT TRANSMEM 236..254
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369091"
FT DOMAIN 106..292
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT DOMAIN 313..377
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 479 AA; 54110 MW; 92444E611B33678E CRC64;
MYAFDFFHRE SLEIVEETGA IQLFGEDVDL VKSAYLSTDS ACDFPAYRLQ KQKSNSTKQP
GDERNFVEFG MKNGMRSRDK QTDFFVCTKP RSTDFDRMIR IPEGKDFESV YFMMPVLVCC
LLLSATFSGL NLAIMSFSIT DLKLIQGSDT HKINRQRAGD VLRLRRHSNY VLVTIIFGNC
FCNTSITILL NYFGDFYGFG DFGYVELTAT ALLLIFTEIL PSLICTKNAL YVASRMQYFV
IFAMVVTMPI SYPLSKLLDR ILGKENADES TPIEIGTVQL EAMLDETMDD GLGMMNVVQK
TLALRKKRAE DVMTPIARVG MISDTQAVTQ DFLTAAYENG HSRLPVYENK NINKICGVLN
ITDVMLLMDD GGRGLDTDLT AGTLLSVLEK RRKHCFALNT LPVQQFMSEL QRGCTMAIVV
EYVGNDIDED DLSDEDMETQ ESYKVIGIIT LEDYMEEIIG EISDEKDKKD KKGIPQKIK
//
