ID A0A1I7V2P8_9PELO Unreviewed; 513 AA.
AC A0A1I7V2P8;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Ion_trans_2 domain-containing protein {ECO:0000313|WBParaSite:Csp11.Scaffold630.g21790.t2};
OS Caenorhabditis tropicalis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=1561998 {ECO:0000313|Proteomes:UP000095282, ECO:0000313|WBParaSite:Csp11.Scaffold630.g21790.t2};
RN [1] {ECO:0000313|WBParaSite:Csp11.Scaffold630.g21790.t2}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC ECO:0000256|RuleBase:RU003857}.
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DR AlphaFoldDB; A0A1I7V2P8; -.
DR STRING; 1561998.A0A1I7V2P8; -.
DR WBParaSite; Csp11.Scaffold630.g21790.t2; Csp11.Scaffold630.g21790.t2; Csp11.Scaffold630.g21790.
DR eggNOG; KOG1418; Eukaryota.
DR Proteomes; UP000095282; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005267; F:potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR PANTHER; PTHR11003:SF240; TWIK FAMILY OF POTASSIUM CHANNELS; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU003857};
KW Ion transport {ECO:0000256|RuleBase:RU003857};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003857};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT TRANSMEM 101..122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 199..220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 352..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 192..252
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 305..378
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 513 AA; 58862 MW; 1DE06B81B4C77372 CRC64;
MLLSHGEHRQ SFKQKKAEEK RRRSSGHQPQ AKQSLAVLAQ LMLPALIEEH TAQQEEVFVP
QHYKADGTLA SNRRHVRQQR VNLLQRANGQ MRKGAAGVWD HAVLIFVFLI YCIAGGLVFW
LIEEPYQSEL RDKWIQKIEG NRTERVDFLM KRIFNNSDYL VYIKGNTTKR LTQFFKEEFA
SYENQLGVKW SQQKMDWDFW NAVLFAGTIC TTIGYGHIYP MTDAGRLLTM CFALFGIPLM
LLVLQDFGKL LTITMKFPWF QTKRLMRRIM RCCTKQPIEE MKEIERQERA DLDIFDLPLP
VGIGLIVVWI FICSFVLSVW DHNWTLLESF YFFFTSLSTV GLGDLVPSSP RLLITMFGFI
LVGLSLVSMV INLLQAKMKS TYEAGRNDEK AAAHHLPTSL GVIQCFSEEE KKADYSERSL
SRSTQTSLSL PGVRQVVLRS DGVHWVHTDT SSPTKSPDEV TNLVEMETAL RVCEQIGDNN
NEEFSEGESL ICETEVLLEL GECLSDLERC DSI
//
