ID   A0A1I7V5L2_LOALO        Unreviewed;       940 AA.
AC   A0A1I7V5L2;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Kunitz/Bovine pancreatic trypsin inhibitor domain-containing protein {ECO:0000313|WBParaSite:EN70_10128};
OS   Loa loa (Eye worm) (Filaria loa).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX   NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_10128};
RN   [1] {ECO:0000313|Proteomes:UP000095285}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA   Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA   Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Loa loa.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:EN70_10128}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
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DR   AlphaFoldDB; A0A1I7V5L2; -.
DR   WBParaSite; EN70_10128; EN70_10128; EN70_10128.
DR   eggNOG; KOG4295; Eukaryota.
DR   Proteomes; UP000095285; Unassembled WGS sequence.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   CDD; cd22593; Kunitz_conkunitzin; 5.
DR   Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 5.
DR   InterPro; IPR006150; Cys_repeat_1.
DR   InterPro; IPR002223; Kunitz_BPTI.
DR   InterPro; IPR036880; Kunitz_BPTI_sf.
DR   InterPro; IPR028150; Lustrin_cystein.
DR   PANTHER; PTHR46339; PROTEIN CBG15282-RELATED; 1.
DR   PANTHER; PTHR46339:SF9; PROTEIN CBG19340; 1.
DR   Pfam; PF00014; Kunitz_BPTI; 5.
DR   Pfam; PF14625; Lustrin_cystein; 5.
DR   SMART; SM00131; KU; 5.
DR   SMART; SM00289; WR1; 5.
DR   SUPFAM; SSF57362; BPTI-like; 5.
DR   PROSITE; PS50279; BPTI_KUNITZ_2; 5.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000095285}.
FT   DOMAIN          179..229
FT                   /note="BPTI/Kunitz inhibitor"
FT                   /evidence="ECO:0000259|PROSITE:PS50279"
FT   DOMAIN          469..519
FT                   /note="BPTI/Kunitz inhibitor"
FT                   /evidence="ECO:0000259|PROSITE:PS50279"
FT   DOMAIN          623..673
FT                   /note="BPTI/Kunitz inhibitor"
FT                   /evidence="ECO:0000259|PROSITE:PS50279"
FT   DOMAIN          729..779
FT                   /note="BPTI/Kunitz inhibitor"
FT                   /evidence="ECO:0000259|PROSITE:PS50279"
FT   DOMAIN          858..908
FT                   /note="BPTI/Kunitz inhibitor"
FT                   /evidence="ECO:0000259|PROSITE:PS50279"
FT   REGION          919..940
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   940 AA;  102727 MW;  A53330E469BFF8A9 CRC64;
     MPFVTTQITA TEMSMSTSST ESTLNFEKFK DLLSSITSIT NSSNIFLSTT RKPNIEIAIP
     TISYWNLSST IKTELISTTN NPNKYSIPFG ENPNVQNVVS QMSQNNEVSS VQSKQEVDGI
     VDLISNANTD PCLQPLPIGF QLQYCSPTDS FLCPRGTFCQ IGAGPQQTFC CPIIADNPCK
     QKQESGIGLI GLKRWYYDAN DNYCKTFIFN GFKGNQNNFL TFRICQQSCG AINPCENGEP
     QIQTNVQEQC SPENVHSCPK GYYCRILDDL TKSVCCPGTD QTVLINDRVI MPNPLANVNS
     GSGSIYNLNN GHSLTTNIDY MKSRTVDSID SANMAIGSIA PIESINYGNT KPINSNEYLG
     YNAATGIKPN FSNISQSNNF INQVGTSDFT RAGTFINSYY GIPKSGMISE SIGSGIPIFT
     GNSPVNTGVS VDSSSGTAFE NARISSEFNS GTQNLAPNIA IENIRGNRCL QALAPGTGTY
     SLPRYHFDAE ASLCRPFIYS GFGGNDNSFE TIQECRMACP EYDNPCPVGL PYVDENDGSV
     AFCSSINPLC PSNYWCHIGD RRQTSVCCPS LINFNTMPIT NQFRPLRSLL STNFMQNFNG
     PALDMRIGSS EHNDMPGMIS QACFQSLQEG RGQAKLTRYY FNSRTRTCEK FIYSGKGGNQ
     NNFLSKMDCE ETCPILDNPC ENGLPAMSSE GNPILCDSDS STICGIGYYC HIGATSSTTV
     CCPTIGDPCH MPVSNGNGNA ILNRWYYNTQ SQICVNFVYS GQGGNSNNFR TREDCIKTCP
     EFRFDYILLK FLGLNHKLNL GNIYERNPCS AGRPHIGLNG QITRCGATGP LICPTTYWCH
     IGASLENSVC CPATGIPCEQ EVEIGTGDAV LIRFYYNSAT RTCQQFQYSG LGGNENNFLT
     LRDCEAHCPV LPNPCGLGQP QTDEHQNPVM CSAADTKPVT
//