ID A0A1I7V5S9_LOALO Unreviewed; 520 AA.
AC A0A1I7V5S9; A0A1S0UHE8;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Arf-GAP domain-containing protein {ECO:0000313|WBParaSite:EN70_10189};
GN ORFNames=LOAG_17679 {ECO:0000313|EMBL:EJD75122.1,
GN ECO:0000313|WBParaSite:EN70_10189};
OS Loa loa (Eye worm) (Filaria loa).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_10189};
RN [1] {ECO:0000313|EMBL:EJD75122.1, ECO:0000313|Proteomes:UP000095285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Genome Sequencing Center for Infectious Disease;
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Loa loa.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:EN70_10189}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
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DR EMBL; JH712177; EJD75122.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I7V5S9; -.
DR STRING; 7209.A0A1I7V5S9; -.
DR EnsemblMetazoa; EJD75122.1; EJD75122.1; LOAG_17679.
DR WBParaSite; EN70_10189; EN70_10189; EN70_10189.
DR eggNOG; KOG0706; Eukaryota.
DR InParanoid; A0A1I7V5S9; -.
DR OMA; ENGPSKV; -.
DR OrthoDB; 389572at2759; -.
DR Proteomes; UP000095285; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd08959; ArfGap_ArfGap1_like; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR PANTHER; PTHR45686:SF4; ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H; 1.
DR PANTHER; PTHR45686; ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED; 1.
DR Pfam; PF01412; ArfGap; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR PROSITE; PS50115; ARFGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00288}; Reference proteome {ECO:0000313|Proteomes:UP000095285};
KW Zinc {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00288}.
FT DOMAIN 14..130
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REGION 248..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..277
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 520 AA; 56708 MW; 620F23B3C9C81B5B CRC64;
MGATEEAPLK ADIQTVFRKL RAIPCNKECF DCGARNPTWA SVTYGIYLCI DCSAIHRNLG
VHISFVRSTT LDTKWTWLQL RAMQIGGNAK ANNFFKQHGC NTNDAQQKYN SRASNLYKEK
LASLALEAHR QHGTSLMMES SDLTADEGSE EKSAKEDVDF FSQDFVAHQS NSSCSISQDA
FIDNGSDAVL GPSVETLSLS DAHREQNVPL KSKITSKKVS VKKSGLGARK GMGAHRITAN
FGEIEQKASN YDREKEALES STIKDAGNDD TDSDGSKTKV SSRFLMQELE KKAKQKASTV
DQSKADVIER LGMGSGGAIF GKGRISHSVA SGIKTIPQEG ISRNTNRTII PNRREGEWEI
IDDDLRGNEG RSNIVDDRGV ENTEENDFFG SWETPASTTT IKKPSRPTIT TAVIEPSNDS
ALKKFANARA ISSDQYFGGV QVDYEAQSRL NRFEGSSAIG SADLFGNGEN SSYGGGYASQ
MPEMATIRDS MRMGASKVAG KLSSLSSSVA YYLANNQDRY
//
