ID A0A1I7V645_LOALO Unreviewed; 504 AA.
AC A0A1I7V645; A0A1S0U5U0;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=fumarate hydratase {ECO:0000256|ARBA:ARBA00012921};
DE EC=4.2.1.2 {ECO:0000256|ARBA:ARBA00012921};
GN ORFNames=LOAG_03614 {ECO:0000313|EMBL:EFO24875.2,
GN ECO:0000313|WBParaSite:EN70_10293};
OS Loa loa (Eye worm) (Filaria loa).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_10293};
RN [1] {ECO:0000313|EMBL:EFO24875.2, ECO:0000313|Proteomes:UP000095285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Genome Sequencing Center for Infectious Disease;
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Loa loa.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:EN70_10293}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate
CC from fumarate: step 1/1. {ECO:0000256|ARBA:ARBA00004859}.
CC -!- SIMILARITY: Belongs to the class-II fumarase/aspartase family. Fumarase
CC subfamily. {ECO:0000256|ARBA:ARBA00009084}.
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DR EMBL; JH712156; EFO24875.2; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I7V645; -.
DR STRING; 7209.A0A1I7V645; -.
DR EnsemblMetazoa; EFO24875.2; EFO24875.2; LOAG_03614.
DR WBParaSite; EN70_10293; EN70_10293; EN70_10293.
DR eggNOG; KOG1317; Eukaryota.
DR InParanoid; A0A1I7V645; -.
DR OMA; AKWRAQT; -.
DR OrthoDB; 1341425at2759; -.
DR UniPathway; UPA00223; UER01007.
DR Proteomes; UP000095285; Unassembled WGS sequence.
DR GO; GO:0045239; C:tricarboxylic acid cycle enzyme complex; IEA:InterPro.
DR GO; GO:0004333; F:fumarate hydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0006106; P:fumarate metabolic process; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR CDD; cd01362; Fumarase_classII; 1.
DR Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR HAMAP; MF_00743; FumaraseC; 1.
DR InterPro; IPR005677; Fum_hydII.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR018951; Fumarase_C_C.
DR InterPro; IPR020557; Fumarate_lyase_CS.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR NCBIfam; TIGR00979; fumC_II; 1.
DR PANTHER; PTHR11444; ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE; 1.
DR PANTHER; PTHR11444:SF1; FUMARATE HYDRATASE, MITOCHONDRIAL; 1.
DR Pfam; PF10415; FumaraseC_C; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00145; ARGSUCLYASE.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
DR PROSITE; PS00163; FUMARATE_LYASES; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000095285}.
FT DOMAIN 52..383
FT /note="Fumarate lyase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00206"
FT DOMAIN 449..501
FT /note="Fumarase C C-terminal"
FT /evidence="ECO:0000259|Pfam:PF10415"
SQ SEQUENCE 504 AA; 54166 MW; D016A6149DF7F317 CRC64;
MLTRIALVGI GRSGNIYGVT RSSSAVAAIR AVNSVVKRNM ATTIRKERDT FGELQVPADR
YYGAQTARSM MNFKIGGPEE RMPLPVIHAF GILKKAAALV NKEYGLDQKI VDAIAKAADE
VIAGKLDDHF PLVVWQTGSG TQSNMNVNEV ISNRAIEMLG GELGSKKPVH PNDHVNMSQS
SNDTYPTAMH IAVARELNSR LLPSLQQLLD SLRQKSKEFE NIIKIGRTHT QDAVPLTLGQ
EFGGYAQQVE NGIARVKDTL PRLYMLAAGG TAVGTGLNTR IGFAEKIAAK IAELTGLPFV
TAPNKFEALA AHDAMVEVHG ALNTTAASLM KIANDIRFLG SGPRCGLGEL SLPENEPGSS
IMPGKVNPTQ CEAVTMVAAQ VFGNQVAVTV GGSNGHFELN VFKPMIVRNV LQSTRLIADA
SVSFAVNCVD GIKANKENIA KILRESLMLV TALNPHIGYD NAAKIAKTAH KNGTTLKEEA
VKLGILTAEQ FDEWVRPEKM LAPK
//
