ID A0A1I7V6W4_LOALO Unreviewed; 1152 AA.
AC A0A1I7V6W4;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 {ECO:0000313|WBParaSite:EN70_10535};
OS Loa loa (Eye worm) (Filaria loa).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_10535};
RN [1] {ECO:0000313|Proteomes:UP000095285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Genome Sequencing Center for Infectious Disease;
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Loa loa.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:EN70_10535}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
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DR AlphaFoldDB; A0A1I7V6W4; -.
DR STRING; 7209.A0A1I7V6W4; -.
DR WBParaSite; EN70_10535; EN70_10535; EN70_10535.
DR eggNOG; KOG0521; Eukaryota.
DR Proteomes; UP000095285; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd08834; ArfGap_ASAP; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR043593; ASAP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45854:SF3; ARFGAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45854; ASAP FAMILY MEMBER; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Reference proteome {ECO:0000313|Proteomes:UP000095285};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 340..433
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 463..585
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 1087..1152
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 813..835
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 901..935
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1152 AA; 128874 MW; DBC46175802C6881 CRC64;
MAASESEGSY GAMLSSFTTS VKADLDSPVT SNFGNRIVEY RAEAQRIVEE AEGYTVDFER
LRKAAKEVED TLVILSRQLL AFGQTAKEIA TKWTSRSESQ YESDVAVILM KMECHIKDEA
DLTNLQMRNW QSNIVTPFLT LVEILREIRN RGVERSCRDY ENKYMKAEAD ARKHAKHAGY
TRSQLGHGEL AEQLTRERLM VQYELCKFLM SVDSIEDRRG PQLLRHFMEL VRNQNSYYMN
RVRVNEDFRQ DMTKLEERMM TRNANRCAKR NALWDLKGQL EANDEFARSA SGRRSSGRDS
MNLGSRLSGI NLISASSALL TDNDPLSELA TSTAFFPDLD FTQSGYLYKK SNKKLHKQWQ
KRRCRIEDGH FWLSHSDESI PPTKLSLLVS DCKPSTDDPK TFDLYCRERT YHLQADSETD
AKRWMLALKR EITRVKTKML SAETPQGSEG GSSGAVSELY ERKMCIAKVR QLPGNSICAD
CSSKEDVQWL SNIGALVCIA CSGVHRELGV HVSRIQSLNL DVISPLEFFV PLSSGNVVIN
RLFEYDAAKC ATWKPIPGCT RFDRQRFIQM KYRDRAFVQK LDDPDVSLTE AFNDCDFENA
YRALLSSNLT RKPFLQNGPF HQMVLRGTSL SLPVADLVMQ LRIEIPDMET IMMDCIRSGN
ADMVAILLRY RSLSSTVRGI HLHSLITCSE KAQQKKITEM LRSLQLGDST QVQNVAVPPI
LFVSTPDSAS LSRSSSSVSP CPHLPPDSIA SQNFTSKPVN VLMRNGTTIS VPRSSLSMEE
IRSNRLSKQT FVANEPAHSS VGEGVVQITI SGPSSSETYA HNNTQPSSSM NSDGEKDLLT
FELPLCTSTP SSIISSARTV APSNHYSQTL ASVPISSPLP ISAAPTQSNA KCYIRSASEY
SRTTNYSENN SRSGTVRSLP GHLAPQSSST KGSDGVVETT LPIAASMSLN PIPLNAQKHA
MNIYVVAPGK EEIIDKEKCV AETRDEREGS IRNPHLTDEQ ETVKATSLAL DQVRSNFTSC
DEHPRSSLMN PLAANGLQRE MPRYISKSKR LTRPAPAPPA LFGVKLKPPI PAPRRLPSIT
RENKQRDCAR RCRALYDCKA DNSDELSFRQ GDIIVITKEK IIGENDTWME GYLENNPLCR
GVFPITFVTF LS
//
