ID A0A1I7V7I7_LOALO Unreviewed; 510 AA.
AC A0A1I7V7I7;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Protein wntless-like protein {ECO:0000313|WBParaSite:EN70_10736};
OS Loa loa (Eye worm) (Filaria loa).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_10736};
RN [1] {ECO:0000313|Proteomes:UP000095285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Genome Sequencing Center for Infectious Disease;
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Loa loa.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:EN70_10736}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the wntless family.
CC {ECO:0000256|ARBA:ARBA00008148}.
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DR RefSeq; XP_003147406.1; XM_003147358.1.
DR AlphaFoldDB; A0A1I7V7I7; -.
DR STRING; 7209.A0A1I7V7I7; -.
DR WBParaSite; EN70_10736; EN70_10736; EN70_10736.
DR eggNOG; ENOG502QSE2; Eukaryota.
DR Proteomes; UP000095285; Unassembled WGS sequence.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017147; F:Wnt-protein binding; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR047843; WLS-like_TM.
DR InterPro; IPR009551; Wntless.
DR PANTHER; PTHR13449; INTEGRAL MEMBRANE PROTEIN GPR177; 1.
DR PANTHER; PTHR13449:SF2; PROTEIN WNTLESS HOMOLOG; 1.
DR Pfam; PF06664; MIG-14_Wnt-bd; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000095285};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT TRANSMEM 204..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 237..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..327
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 349..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 405..425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 144..473
FT /note="Wntless-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF06664"
SQ SEQUENCE 510 AA; 58866 MW; 4ED00B3EF9E31C18 CRC64;
MEFIMVKCKD IEGGRNPDRW FHLRPPNCDP IHDLDYYIPQ YHDMRDIVFV AQMPHQRDGI
SLEYSAWFQF LLGLLEVDIE YDPKFTLATS AVLQLEVRLG YKTRTDPPDQ WHELIATNTT
RMLECSIPDT VKFDRSKLEG HLYNCASLDL FELGSNPYPF YLINIRLPVN QSLCRTMPKG
PNCAIGRIND LRVIAIHQNG GFTAIWLFMK TMVSPLVTIA VIWYWKRVVA LNRNSYLLEK
AIMALGISLA ILDFPLEWIS LWFRAPFMLL IGDIRQGLFY AILFSFWLIF TGEHLIDDTS
RNNLSSYWQN LTSVLIGSAC LLIYDVAERG MQLLNPFFSI WSSELGSRIA YASIYIASLC
VLFYFGFLAY KIYRVWITIK RKRSAQLYRS SEIRRLKVEA IIYRFKFLMF FTLVCAASTV
ITYIMKQYGE GQIHSDNPSE SLLVHSSSAF FTGTFGMWNI YVLLLLAMYA PSHKQYGTTV
ALREETDTLV DSELTESSAL TTFMKAATTE
//
