ID A0A1I7V8P3_LOALO Unreviewed; 1511 AA.
AC A0A1I7V8P3;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Suppressor of Ty 6 homolog {ECO:0000256|PIRNR:PIRNR036947};
OS Loa loa (Eye worm) (Filaria loa).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_11091};
RN [1] {ECO:0000313|Proteomes:UP000095285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Genome Sequencing Center for Infectious Disease;
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Loa loa.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:EN70_11091}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- FUNCTION: May regulate transcriptional elongation by RNA polymerase II.
CC {ECO:0000256|PIRNR:PIRNR036947}.
CC -!- SUBUNIT: Interacts with glp-1 and lin-12.
CC {ECO:0000256|PIRNR:PIRNR036947}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR036947}.
CC -!- SIMILARITY: Belongs to the SPT6 family. {ECO:0000256|ARBA:ARBA00009253,
CC ECO:0000256|PIRNR:PIRNR036947}.
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DR STRING; 7209.A0A1I7V8P3; -.
DR WBParaSite; EN70_11091; EN70_11091; EN70_11091.
DR eggNOG; KOG1856; Eukaryota.
DR Proteomes; UP000095285; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0032968; P:positive regulation of transcription elongation by RNA polymerase II; IEA:UniProtKB-UniRule.
DR GO; GO:0140673; P:transcription elongation-coupled chromatin remodeling; IEA:InterPro.
DR CDD; cd09928; SH2_Cterm_SPT6_like; 1.
DR CDD; cd09918; SH2_Nterm_SPT6_like; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 1.10.10.650; RuvA domain 2-like; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 1.10.10.2740; Spt6, Death-like domain; 1.
DR Gene3D; 1.10.150.850; Spt6, helix-hairpin-helix domain; 1.
DR Gene3D; 1.10.3500.10; Tex N-terminal region-like; 1.
DR Gene3D; 3.30.420.140; YqgF/RNase H-like domain; 1.
DR InterPro; IPR041692; HHH_9.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR042066; Spt6_death-like.
DR InterPro; IPR032706; Spt6_HHH.
DR InterPro; IPR035420; Spt6_SH2.
DR InterPro; IPR035018; Spt6_SH2_C.
DR InterPro; IPR035019; Spt6_SH2_N.
DR InterPro; IPR028231; Spt6_YqgF.
DR InterPro; IPR023323; Tex-like_dom_sf.
DR InterPro; IPR023319; Tex-like_HTH_dom_sf.
DR InterPro; IPR017072; TF_Spt6.
DR InterPro; IPR006641; YqgF/RNaseH-like_dom.
DR InterPro; IPR037027; YqgF/RNaseH-like_dom_sf.
DR PANTHER; PTHR10145; TRANSCRIPTION ELONGATION FACTOR SPT6; 1.
DR PANTHER; PTHR10145:SF6; TRANSCRIPTION ELONGATION FACTOR SPT6; 1.
DR Pfam; PF14635; HHH_7; 1.
DR Pfam; PF17674; HHH_9; 1.
DR Pfam; PF00575; S1; 1.
DR Pfam; PF14633; SH2_2; 1.
DR Pfam; PF14639; YqgF; 1.
DR PIRSF; PIRSF036947; Spt6; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00732; YqgFc; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 2.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158832; Tex N-terminal region-like; 1.
DR PROSITE; PS50126; S1; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR036947};
KW Reference proteome {ECO:0000313|Proteomes:UP000095285};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR036947};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR036947}.
FT DOMAIN 1211..1268
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 1310..1417
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 1..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..117
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..256
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..272
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1511 AA; 176605 MW; 92D9786AB3FDE890 CRC64;
MSEFLDNQAE ESENSGETTD TSIDDDDLEP RAKRKRKQKK KKEKAKKTKR IRSDDEDDEE
DDDGEDDEAK IQKEMAGFVV DEDEAEEDGD DNEDDDRSDI EKDDDLELDD EDLDLLNDNL
DIQQRPAGGR VVIESDEEED RDRSKSNLYD KDDLAGDDDQ RSDYRESERR VYDGDEGSGT
ESEHSEDDFI VTDDGQQPQH RQRRYRFADV PEQAIDDARE IFGVDDFNFA EFYDEDAEPG
EDEDEYPEDE EQEELEGGDV SRSRKMKPKE KRATLMDTIE PAELEEKLLS PMDKRIQLDD
RPERFQLRRV PVCEADEHEL EIEAKWIYQY AFDNATLSEQ EESCLTVLSN LDLRIDERAK
IAAEAPDKIK EALKFIRNQL FEANRNFFSL FPFYRKEYVE SCLVINDLWK VYQWDEKWCH
LQQRKKRLLE LMKRMLNYQM ENDNAAGMRI VTEQDMNEVH GVQTVEGLMD VSTKFQLYYG
PEVPKMIDWE KIQNLSEDDP EREAAEMRFR AATRTDKYML CVQNGLSGMA SRFGLTPLQF
AENLDWKRHD IVQDDEEPLK AAEQYVCQSF PTPEAVLTGA IHVVAKQLSR EPKVRELLRL
RYRLRLKISV CPTKKGREEI DENHKLWPRR YIRDKPVASL RHDEYLWYVQ AHAGGLLNLK
LHCDTEDDVR FEKTMLQEFL SEQPYHRDEY SRVVDTWNKI REEAVTVCVN NFLLPVFERE
AHERLLQEAK DYVIKQSTQN LYDRIKTAAY RNVHDDDDDD FESGFASGTR VLSIAYPEER
DQASFCALLD QDGQVLDHLR LIHITKSMNS KRPGEADLKR QDMVHLRKFI EKRRPCVIAI
CGENMDAYYL RRDIESLLHE ISGMAKEIPV EIVDNEAAKI YMHSKQAIAE FPNYPLMLRQ
AVSLGRLLLD PLIEYAHLCN TDDDILCVSY HPLQSEVNKE ELLFALSLEF INRVNEVGVD
VNRCLEYSHT SYLLQFVCGL GTRKAVHLLK ILKQNDNLLE SRTKLVTLCR MGPKVFMNSA
GFIKIDTAKV SERTDAYVEV LDGSRVHPET YEWARKMAVD ALEIDDAADP TSALEEILQN
PDKLKDLDLD AFAEELARQG FGNKSITLYD IRAELNHRYK DLRIPYESPS AEKIFTMLTK
ETSDSIGKLV MGRVMHIVYR KPRDPEERER VPPIRDERTG QWKCQYCYKP DFNNTNEVWQ
HIDSCPGQPV GVKVRFDSGI TGFIPNKYLS DRPDSFVDPS ERVRRNQPIY CRILELDPDK
FSATCSCRSS DLRGLQPQNS EFDRYFDKLK YQDDDEKDKK LREKRKIVTY FVKRVISHPS
FHNVTFKDAE RMLQKFEQGE AIIRPSSKSV SHLTVTWKVA DGIYQHIDIK EEGKQHQFSL
GKTLLIGTEE FEDLDEILAR HIQPMAALAR DVLSHKYFLD GKRAEDRDAI ESYLFDEKKR
NPQRIPYTLT PSQEYPGKFV VSYLPRNKAR HEYMTVTPEG FRFRQQLFQS LEVVLSWFKV
HYREPPPGMY R
//
