ID A0A1I7V929_LOALO Unreviewed; 685 AA.
AC A0A1I7V929;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=DNA_mis_repair domain-containing protein {ECO:0000313|WBParaSite:EN70_11212};
GN Name=LOAG_07794 {ECO:0000313|WBParaSite:EN70_11212};
OS Loa loa (Eye worm) (Filaria loa).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_11212};
RN [1] {ECO:0000313|Proteomes:UP000095285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Genome Sequencing Center for Infectious Disease;
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Loa loa.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:EN70_11212}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR AlphaFoldDB; A0A1I7V929; -.
DR STRING; 7209.A0A1I7V929; -.
DR WBParaSite; EN70_11212; EN70_11212; EN70_11212.
DR eggNOG; KOG1979; Eukaryota.
DR InParanoid; A0A1I7V929; -.
DR Proteomes; UP000095285; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032189; Mlh1_C.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF16413; Mlh1_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000095285}.
FT DOMAIN 209..336
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
SQ SEQUENCE 685 AA; 75988 MW; 1A263048FC59EB79 CRC64;
MIRRLPEDVV NRIAAGEVIV RAANAIKELI ENALDAGATE IVITAKNGGL DLLKVQDNGK
GIAKDDLPIV CERFTTSKLE RYEDLECMST FGFRGEALAS ITHVAKVTII SKIPDSPCAY
VGRYTDSKLQ GNIKPSAGLD GTTVTAEDLF YNCPSRRRAL KYPADEMNRI ADVVVRYAIH
NPSVSFTLRR CGSGSDFRTA GTNNLCETIS SLLGGKFSKD LILLNHGDSA LYFTLKGCLV
RPTASCTAES LQDRQNRQKV FYLFINGRSV ECLALKQALD VVFAAQNTMS PFVMISLQIE
PKRVDVNVHP TKSIVYFLEQ DSIISSIQDY VENLILSLAG SCDVHPKFPL MTDSNDNSSS
KSVDTMTASS TKKKQLTMLV SESLGGPPPS SSIKSPKVYP HQLVRTDAKE RRLEEFVASQ
SLIVSSPCAT NDFNSSVKTL GDGEWRKFEF ESLQSMKEAI CTTASVSLRS LFKEHIYVGA
VNVDQVLIQH STSIYLVDAQ DCLRNFFYQI LVLSFGNFGS FKLSECAPLA ELLHIADSNL
SPTEVQQKAA TVIENREMLD DYFCLSITEN GNLNSIPSLI DGFIPQLESL PQLLLTLAND
ITWNNEQACF EQVCWALSEF FCLKKEFCDG EAISGLSTEK LSWKNAYKDI LFPSLKINFL
PPQKLRCSLH RIADLHDLYK VFERC
//
