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Database: UniProt
Entry: A0A1I7V9B7_LOALO
LinkDB: A0A1I7V9B7_LOALO
Original site: A0A1I7V9B7_LOALO 
ID   A0A1I7V9B7_LOALO        Unreviewed;       328 AA.
AC   A0A1I7V9B7;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   05-DEC-2018, entry version 9.
DE   RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE            EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
DE   AltName: Full=Hyaluronoglucosaminidase {ECO:0000256|RuleBase:RU610713};
OS   Loa loa (Eye worm) (Filaria loa).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX   NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_11239};
RN   [1] {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_11239}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25217238; DOI=10.1186/1471-2164-15-788;
RA   Tallon L.J., Liu X., Bennuru S., Chibucos M.C., Godinez A., Ott S.,
RA   Zhao X., Sadzewicz L., Fraser C.M., Nutman T.B., Dunning Hotopp J.C.;
RT   "Single molecule sequencing and genome assembly of a clinical specimen
RT   of Loa loa, the causative agent of loiasis.";
RL   BMC Genomics 15:788-788(2014).
RN   [2] {ECO:0000313|WBParaSite:EN70_11239}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-
CC         beta-D-glucosamine and D-glucuronate residues in hyaluronate.;
CC         EC=3.2.1.35; Evidence={ECO:0000256|RuleBase:RU610713};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC       {ECO:0000256|RuleBase:RU610713}.
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DR   WBParaSite; EN70_11239; EN70_11239; EN70_11239.
DR   Proteomes; UP000095285; Unassembled WGS sequence.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.70; -; 2.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR018155; Hyaluronidase.
DR   PANTHER; PTHR11769; PTHR11769; 2.
DR   Pfam; PF01630; Glyco_hydro_56; 2.
DR   PRINTS; PR00846; GLHYDRLASE56.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000095285};
KW   Glycosidase {ECO:0000256|RuleBase:RU610713};
KW   Hydrolase {ECO:0000256|RuleBase:RU610713};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095285}.
SQ   SEQUENCE   328 AA;  37444 MW;  402C7508AEA2F0C7 CRC64;
     KEKERPENYG ILVNEGHKFR GDIIVTLYEK QFGLYPYYSD SSDLTSAVNG GIPQRANLSA
     HLSKVRSDID KAIPNKDFDG LAIIDYEEWR PLWEHNWYTR RIYHNASLAY VEEQYKNTGK
     TLTKGDELAK KEFNQAAMNF LTETIREAKN MRPNALWEFY GMPFCNYSAG KNGTEGCGEV
     FEEFNNRLQP LYAEATAFYP SIYLPSRKSG RTGCLYVIPS FKKLNDDLSH SLNTAFVMGV
     QGTIIWSSSK DMVNQCHGIG DYVLKYVDPK VVELKTCDKI ELKTCDKIRR IKKRQIPDQI
     SCAVKNDPAY DNCQNAMTSI NKPAITAK
//
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