ID   A0A1I7VC64_LOALO        Unreviewed;       489 AA.
AC   A0A1I7VC64;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=Spliceosome-associated protein CWC27 homolog {ECO:0000256|ARBA:ARBA00040027};
DE   AltName: Full=Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog {ECO:0000256|ARBA:ARBA00042090};
GN   Name=LOAG_11869 {ECO:0000313|WBParaSite:EN70_12144};
OS   Loa loa (Eye worm) (Filaria loa).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX   NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_12144};
RN   [1] {ECO:0000313|Proteomes:UP000095285}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA   Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA   Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Loa loa.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:EN70_12144}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   AlphaFoldDB; A0A1I7VC64; -.
DR   STRING; 7209.A0A1I7VC64; -.
DR   WBParaSite; EN70_12144; EN70_12144; EN70_12144.
DR   eggNOG; KOG0885; Eukaryota.
DR   InParanoid; A0A1I7VC64; -.
DR   Proteomes; UP000095285; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:InterPro.
DR   GO; GO:0006457; P:protein folding; IEA:InterPro.
DR   CDD; cd01925; cyclophilin_CeCYP16-like; 1.
DR   Gene3D; 2.40.100.10; Cyclophilin-like; 1.
DR   InterPro; IPR029000; Cyclophilin-like_dom_sf.
DR   InterPro; IPR020892; Cyclophilin-type_PPIase_CS.
DR   InterPro; IPR002130; Cyclophilin-type_PPIase_dom.
DR   InterPro; IPR044666; Cyclophilin_A-like.
DR   PANTHER; PTHR45625; PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED; 1.
DR   PANTHER; PTHR45625:SF6; SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG; 1.
DR   Pfam; PF00160; Pro_isomerase; 1.
DR   PRINTS; PR00153; CSAPPISMRASE.
DR   SUPFAM; SSF50891; Cyclophilin-like; 1.
DR   PROSITE; PS00170; CSA_PPIASE_1; 1.
DR   PROSITE; PS50072; CSA_PPIASE_2; 1.
PE   4: Predicted;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095285}.
FT   DOMAIN          26..173
FT                   /note="PPIase cyclophilin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50072"
FT   REGION          256..318
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          396..433
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          450..489
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        268..282
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        450..483
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   489 AA;  56471 MW;  212147FF053596F1 CRC64;
     MDFQAISMSN IYVNEPATNG KVCMKTTVGD IDIELWSKEC PLACRNFIQL CMEGYYNGTI
     FHRVIRDFIV QGGDPTGTGE GGESIYTASF KNEFHQRLKF NRRGLVGMAS GNDGMNGSQF
     FFTLNATPDL DKKHTLFGKV VGNTLFNMLR LGECEIGDDD KPLTKQKILQ VKILSNPFND
     IIPREKKKDK KKKEKIRDKK DAKKNLTLLS FGDEAEEDEI ELQEANEKFK CKSKSAHDIL
     TDETLSKELA VPMEELIEPI EPSSSSNIED TGEREARMER IKEKLRKRKR KASDSDRNDE
     EDEDFEAMIK QEMSDRQKQE LEKITAEVKL VQKDLKAMLK PKKEEEEIEE EKLLTEATKR
     HLEMKQMFRE SAKVKLKSKD PRRQDETMSM LEKILAEHEG MKSFNPVRER NPEKEKKKEE
     EHEVSAGKLN YDNEEDLDTA EILAHKFVAP EEDGKVSKAK DANLREESED WYDITDPRNK
     INQRRRGVV
//