ID A0A1I7VDS6_LOALO Unreviewed; 352 AA.
AC A0A1I7VDS6; A0A1S0UE25;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Pax transcription factor protein 2 {ECO:0000313|EMBL:EFO28340.2, ECO:0000313|WBParaSite:EN70_1443};
GN ORFNames=LOAG_00159 {ECO:0000313|EMBL:EFO28340.2,
GN ECO:0000313|WBParaSite:EN70_1443};
OS Loa loa (Eye worm) (Filaria loa).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_1443};
RN [1] {ECO:0000313|EMBL:EFO28340.2, ECO:0000313|Proteomes:UP000095285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Genome Sequencing Center for Infectious Disease;
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Loa loa.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:EN70_1443}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; JH712150; EFO28340.2; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I7VDS6; -.
DR STRING; 7209.A0A1I7VDS6; -.
DR EnsemblMetazoa; EFO28340.2; EFO28340.2; LOAG_00159.
DR WBParaSite; EN70_1443; EN70_1443; EN70_1443.
DR eggNOG; KOG3862; Eukaryota.
DR InParanoid; A0A1I7VDS6; -.
DR OMA; HLTMDCS; -.
DR OrthoDB; 5398393at2759; -.
DR Proteomes; UP000095285; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00131; PAX; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR043182; PAIRED_DNA-bd_dom.
DR InterPro; IPR001523; Paired_dom.
DR InterPro; IPR043565; PAX_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR45636; PAIRED BOX PROTEIN PAX-6-RELATED-RELATED; 1.
DR PANTHER; PTHR45636:SF31; PAX PROTEIN-RELATED; 1.
DR Pfam; PF00292; PAX; 1.
DR PRINTS; PR00027; PAIREDBOX.
DR SMART; SM00351; PAX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00034; PAIRED_1; 1.
DR PROSITE; PS51057; PAIRED_2; 1.
PE 4: Predicted;
KW Paired box {ECO:0000256|ARBA:ARBA00022724};
KW Reference proteome {ECO:0000313|Proteomes:UP000095285};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 69..195
FT /note="Paired"
FT /evidence="ECO:0000259|PROSITE:PS51057"
FT REGION 297..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..334
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 352 AA; 37848 MW; 83F49D31AB464F3E CRC64;
MIFASAVHPS IFGRSLTHLT MDCSLWPRYA AAAAYSPAGT TVPSPVAGAT SAAAATAAAA
ALYNQPFTSH TGVNQLGGVF VNGRPLPDHI RNRIVELAHQ GVRPCDISRQ LRVSHGCVSK
ILGRYYETGS IRPGVIGGSK PKVATPKVVQ TIAAYKRANP TMFAWEIREK LLEERVCDAE
NVPSVSSINR IVRNKSSMDR LSERALQQTA FLAPTTPYSI NELLGFEQPS KSSMDNSQLV
QQLATNFKTA TKNTFASRFH ASLEKGWEGT GATVIPSSNT NSQTYADGFL DDRWVGSIRD
PEHMPSNGIN LNANPNSNRS NASNSMPSTA STRTSSYVLY SSTNATTATG SY
//
