ID A0A1I7VDY6_LOALO Unreviewed; 148 AA.
AC A0A1I7VDY6; A0A1S0UC68;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Major sperm protein {ECO:0000256|RuleBase:RU003425};
GN ORFNames=LOAG_00126 {ECO:0000313|EMBL:EFO28349.1,
GN ECO:0000313|WBParaSite:EN70_1496};
OS Loa loa (Eye worm) (Filaria loa).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_1496};
RN [1] {ECO:0000313|EMBL:EFO28349.1, ECO:0000313|Proteomes:UP000095285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Genome Sequencing Center for Infectious Disease;
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Loa loa.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:EN70_1496}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- FUNCTION: Central component in molecular interactions underlying sperm
CC crawling. Forms an extensive filament system that extends from sperm
CC villipoda, along the leading edge of the pseudopod.
CC {ECO:0000256|RuleBase:RU003425}.
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DR EMBL; JH712095; EFO28349.1; -; Genomic_DNA.
DR RefSeq; XP_003135714.1; XM_003135666.1.
DR AlphaFoldDB; A0A1I7VDY6; -.
DR STRING; 7209.A0A1I7VDY6; -.
DR EnsemblMetazoa; EFO28349.1; EFO28349.1; LOAG_00126.
DR GeneID; 9937494; -.
DR KEGG; loa:LOAG_00126; -.
DR WBParaSite; EN70_1496; EN70_1496; EN70_1496.
DR CTD; 9937494; -.
DR eggNOG; ENOG502SQPZ; Eukaryota.
DR InParanoid; A0A1I7VDY6; -.
DR OMA; EDKMVVQ; -.
DR OrthoDB; 5596058at2759; -.
DR Proteomes; UP000095285; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000535; MSP_dom.
DR InterPro; IPR008962; PapD-like_sf.
DR PANTHER; PTHR22947; MAJOR SPERM PROTEIN; 1.
DR PANTHER; PTHR22947:SF7; MSP DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF00635; Motile_Sperm; 1.
DR SUPFAM; SSF49354; PapD-like; 1.
DR PROSITE; PS50202; MSP; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|RuleBase:RU003425};
KW Cytoskeleton {ECO:0000256|RuleBase:RU003425};
KW Reference proteome {ECO:0000313|Proteomes:UP000095285}.
FT DOMAIN 32..148
FT /note="MSP"
FT /evidence="ECO:0000259|PROSITE:PS50202"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..47
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 148 AA; 14785 MW; 89D5EAC1270C36CA CRC64;
MGDAPAEGAP PPEAAPPAEG APPAEGGAPP EAAAAPPAGP PTLNIDPPAA QVPAAGGQSV
HQVANPSGVR LAFKVKSTNN NDYRLKPVYG FVEPGATAPL EITRTAGPPK EDKFVIQFKE
AAADAADPAA IFKEGPPTGE VTLPIMAQ
//
