ID   A0A1I7VG50_LOALO        Unreviewed;      1067 AA.
AC   A0A1I7VG50;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=GRAM domain-containing protein {ECO:0000313|WBParaSite:EN70_2189};
OS   Loa loa (Eye worm) (Filaria loa).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX   NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_2189};
RN   [1] {ECO:0000313|Proteomes:UP000095285}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA   Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA   Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Loa loa.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:EN70_2189}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
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DR   AlphaFoldDB; A0A1I7VG50; -.
DR   STRING; 7209.A0A1I7VG50; -.
DR   WBParaSite; EN70_2189; EN70_2189; EN70_2189.
DR   eggNOG; ENOG502SBGX; Eukaryota.
DR   Proteomes; UP000095285; Unassembled WGS sequence.
DR   GO; GO:0003713; F:transcription coactivator activity; IEA:InterPro.
DR   CDD; cd13214; PH-GRAM_WBP2; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR004182; GRAM.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR044852; WBP2-like.
DR   PANTHER; PTHR31606; WW DOMAIN BINDING PROTEIN 2, ISOFORM E; 1.
DR   PANTHER; PTHR31606:SF1; WW DOMAIN-BINDING PROTEIN 2; 1.
DR   Pfam; PF02893; GRAM; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000095285}.
FT   DOMAIN          28..129
FT                   /note="GRAM"
FT                   /evidence="ECO:0000259|Pfam:PF02893"
FT   REGION          198..220
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          424..443
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          647..672
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          933..997
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1035..1067
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        939..959
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        978..997
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1051..1067
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1067 AA;  116201 MW;  B8BFA7340EDC6390 CRC64;
     MSVNTSNTPD GRGVLIYNGE MILVYTDEVG CHFENGPDNI FRGNKSGNLY LTSHRIIFIN
     RKKDSLRSFS MPFHCMKDVK LEQPILGSNF LKGIAVAQPG GNWNGQVTWK LTFSKGGCID
     FGMALLKAVD MAQRFRPHGA PPVYAPPPGN YFAAPPAYYI PPRGNYNGFQ APTNVFPNLP
     PAGDVYMYEA PPPYSGIGPD QPPIPAGQLQ NYGVAPSAPS HQPMYAPPLP SKNAVVAMHA
     MSMSFGNDQQ EAVAADGGFI ANNNIMISDY DQNCQNSILN NVAVEGSKLN ETGNYQTVYS
     EYQSLVGSSV EMTTSGMPSA SAPASYQQLN QMSPQSTVAS ASQFDHITVM TNLQQPSDLY
     TGIPVSSVSN GIAYTIPNST NTAALQIYPP SAITQQVQQS VPALNAMPPT VMQNRPDYSM
     QRLQTSRTSN SRTKTTYSSL LPVTGRGSNR QIANISVVSD DGPTVRQHLQ QQHRARLQQQ
     LALQEKTKTD KDDLMTDYSS ILSPAVDKML PVSTTMNLSA SSSTNMLVSA PMNIPASPSM
     NVLTSPSMNI PASPSTNVPA SPSMNIPPSP SMSISRVPQM PRQQYIPRMA PQKPRIMTDR
     VRRMPMYDNN AYQPAPSFCP QKQRAAEIHE EAIQRAAAVY NQIRGQKFSP SSANPPQPRN
     TAFPRSPATT TIAETSVETV QKKSPARKRN HSMMSASQVR VTVLGTQSEP ATQQIITESD
     HVLPIHGIAG LPKQSRIEVT GTGPGKDVVP RSGDEKPPWQ FIRTTSSAVS IGTTQTMEDC
     SKNDVGMDPS SAQKSFSIQI NNNSFSLPTA EPLLTERIAS STNGSELGMI SGASDLIAAQ
     PVLTGNGSHF SESLREVMAQ VDDDVINYTR EAQYVRKLYF MKRLVESLVI KNGALCDEVS
     RLNQRIRTVI EERRVLAKRL QHHERNRIRR IQTKLKKQAA ARATKTNQSQ STPASATSGT
     EGGLPAGDIE NYESDDSDKT LVSSGAASPN TSTSNFGSLV EQNSYFQMSR VETPEPASRN
     QEFMSKVMLD STVVQEGGKS KMKSGMRRHL PAKRAVTDRK EKKVSSN
//