ID A0A1I7VGJ9_LOALO Unreviewed; 359 AA.
AC A0A1I7VGJ9; A0A1S0TUE8;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Transmembrane protein {ECO:0000313|EMBL:EFO20028.2, ECO:0000313|WBParaSite:EN70_2309};
GN ORFNames=LOAG_08463 {ECO:0000313|EMBL:EFO20028.2,
GN ECO:0000313|WBParaSite:EN70_2309};
OS Loa loa (Eye worm) (Filaria loa).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_2309};
RN [1] {ECO:0000313|EMBL:EFO20028.2, ECO:0000313|Proteomes:UP000095285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Genome Sequencing Center for Infectious Disease;
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Loa loa.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:EN70_2309}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMEM120 family.
CC {ECO:0000256|ARBA:ARBA00009700}.
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DR EMBL; JH712124; EFO20028.2; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I7VGJ9; -.
DR STRING; 7209.A0A1I7VGJ9; -.
DR EnsemblMetazoa; EFO20028.2; EFO20028.2; LOAG_08463.
DR WBParaSite; EN70_2309; EN70_2309; EN70_2309.
DR eggNOG; KOG4758; Eukaryota.
DR InParanoid; A0A1I7VGJ9; -.
DR OMA; ESCLKDW; -.
DR OrthoDB; 314124at2759; -.
DR Proteomes; UP000095285; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR012926; TACAN/TMEM120B.
DR PANTHER; PTHR21433:SF0; TRANSMEMBRANE PROTEIN 120 HOMOLOG; 1.
DR PANTHER; PTHR21433; TRANSMEMBRANE PROTEIN INDUCED BY TUMOR NECROSIS FACTOR ALPHA; 1.
DR Pfam; PF07851; TMPIT; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000095285};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 137..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 359 AA; 41993 MW; 8A15E7F58812D136 CRC64;
MVDEKSPFER AFDEWRSLKD EFEEIEDHHR IYLGKLQKVS KLQEGCQKAV KHCLYRISKI
RESLRSLKGK EQPENIGYLK TMKEGVAELE RRSQDMMGEL PVQDNGLYLS IILGSNLNVS
LMNKNDRYRY KQEYEKFKVT VNCALLSLLF LAYIFTSRVL DLVINFVLVW FYCTLTIREA
ILRINGSRIK GWWIIHHYVS CVLSGITVTW GDGECYRSIR TQFIMFCFFL SFVQLLQCRY
QTGCLRRLHA LGQRYSMDIS VEGFSSWMFK GLTFLLPFLM LTYVFQFYNS YKLYYLSKAS
ICINQWQVQI LACGFFLVAC CNMSTLLSVL VNKWKQGGQT STIAALRSKY STSLPDKVQ
//
