ID A0A1I7VHP6_LOALO Unreviewed; 329 AA.
AC A0A1I7VHP6; A0A1S0TK78;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=DM domain-containing protein {ECO:0000313|WBParaSite:EN70_2698};
GN ORFNames=LOAG_13296 {ECO:0000313|EMBL:EFO15216.1,
GN ECO:0000313|WBParaSite:EN70_2698};
OS Loa loa (Eye worm) (Filaria loa).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_2698};
RN [1] {ECO:0000313|EMBL:EFO15216.1, ECO:0000313|Proteomes:UP000095285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Genome Sequencing Center for Infectious Disease;
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Loa loa.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:EN70_2698}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00070}.
CC -!- SIMILARITY: Belongs to the DMRT family.
CC {ECO:0000256|ARBA:ARBA00006834}.
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DR EMBL; JH712370; EFO15216.1; -; Genomic_DNA.
DR RefSeq; XP_003148853.1; XM_003148805.1.
DR STRING; 7209.A0A1I7VHP6; -.
DR EnsemblMetazoa; EFO15216.1; EFO15216.1; LOAG_13296.
DR GeneID; 9950767; -.
DR KEGG; loa:LOAG_13296; -.
DR WBParaSite; EN70_2698; EN70_2698; EN70_2698.
DR CTD; 9950767; -.
DR eggNOG; KOG3815; Eukaryota.
DR OMA; CIMVERR; -.
DR OrthoDB; 3092745at2759; -.
DR Proteomes; UP000095285; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 4.10.1040.10; DM DNA-binding domain; 2.
DR InterPro; IPR001275; DM_DNA-bd.
DR InterPro; IPR036407; DM_DNA-bd_sf.
DR InterPro; IPR026607; DMRT.
DR PANTHER; PTHR12322; DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT; 1.
DR PANTHER; PTHR12322:SF116; DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR 1; 1.
DR Pfam; PF00751; DM; 2.
DR SMART; SM00301; DM; 2.
DR SUPFAM; SSF82927; Cysteine-rich DNA binding domain, (DM domain); 2.
DR PROSITE; PS40000; DM_1; 2.
DR PROSITE; PS50809; DM_2; 2.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00070};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00070};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00070}; Reference proteome {ECO:0000313|Proteomes:UP000095285};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00070}.
FT DOMAIN 19..66
FT /note="DM"
FT /evidence="ECO:0000259|PROSITE:PS50809"
FT DOMAIN 168..215
FT /note="DM"
FT /evidence="ECO:0000259|PROSITE:PS50809"
FT DNA_BIND 19..66
FT /note="DM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00070"
FT DNA_BIND 168..215
FT /note="DM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00070"
FT REGION 64..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 288..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..93
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 329 AA; 36478 MW; EDE98F8B7549100F CRC64;
MNIEEILPEL FGEKRVYYCQ RCLNHGLEVK RKNHKSECAY RFCICNDCQM VDKRRELNSR
LLQIESVSPP PPPPPIPPPP LPPSQPQLSL LPPLPPSSSS SLSTSSLSSS LSSLSSSSSS
SLSQPSSKNG NILTTTVPVL PDMNIFSPVP EQAISPPAMK GKERRPNCQR CAQHSVLARL
KGHKRCCPFR DCPCAKCQVV QERQKLMADQ IKLRRRQKKQ KNLDALNDTD NLRSYPKHQG
ALFSGCLKCA QQALAYQQIL AFIDPTVTLQ PSTFSAILAA CPHNNYNDNN NHDNNNNNNN
NSNNSSSNNN SNNSGSKNNS NNNNDCRNN
//
