ID A0A1I7VI62_LOALO Unreviewed; 501 AA.
AC A0A1I7VI62; A0A1S0U699;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Innexin {ECO:0000256|RuleBase:RU010713};
GN Name=inx {ECO:0000256|RuleBase:RU010713};
GN ORFNames=LOAG_02718 {ECO:0000313|EMBL:EFO25769.1,
GN ECO:0000313|WBParaSite:EN70_2838};
OS Loa loa (Eye worm) (Filaria loa).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_2838};
RN [1] {ECO:0000313|EMBL:EFO25769.1, ECO:0000313|Proteomes:UP000095285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Genome Sequencing Center for Infectious Disease;
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Loa loa.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:EN70_2838}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- FUNCTION: Structural component of the gap junctions.
CC {ECO:0000256|RuleBase:RU010713}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU010713};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU010713}. Cell
CC junction, gap junction {ECO:0000256|RuleBase:RU010713}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the pannexin family. {ECO:0000256|PROSITE-
CC ProRule:PRU00351, ECO:0000256|RuleBase:RU010713}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00351,
CC ECO:0000256|RuleBase:RU010713}.
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DR EMBL; JH712245; EFO25769.1; -; Genomic_DNA.
DR RefSeq; XP_003138303.1; XM_003138255.1.
DR AlphaFoldDB; A0A1I7VI62; -.
DR STRING; 7209.A0A1I7VI62; -.
DR EnsemblMetazoa; EFO25769.1; EFO25769.1; LOAG_02718.
DR GeneID; 9940103; -.
DR KEGG; loa:LOAG_02718; -.
DR WBParaSite; EN70_2838; EN70_2838; EN70_2838.
DR CTD; 9940103; -.
DR eggNOG; ENOG502RRNR; Eukaryota.
DR InParanoid; A0A1I7VI62; -.
DR OMA; ESWINII; -.
DR OrthoDB; 2883020at2759; -.
DR Proteomes; UP000095285; Unassembled WGS sequence.
DR GO; GO:0005921; C:gap junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR InterPro; IPR000990; Innexin.
DR PANTHER; PTHR11893; INNEXIN; 1.
DR PANTHER; PTHR11893:SF9; INNEXIN-7; 1.
DR Pfam; PF00876; Innexin; 1.
DR PRINTS; PR01262; INNEXIN.
DR PROSITE; PS51013; PANNEXIN; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|RuleBase:RU010713};
KW Gap junction {ECO:0000256|ARBA:ARBA00022868, ECO:0000256|PROSITE-
KW ProRule:PRU00351}; Ion channel {ECO:0000256|RuleBase:RU010713};
KW Ion transport {ECO:0000256|RuleBase:RU010713};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00351}; Reference proteome {ECO:0000313|Proteomes:UP000095285};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00351};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU00351}; Transport {ECO:0000256|RuleBase:RU010713}.
FT TRANSMEM 53..75
FT /note="Helical"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT ECO:0000256|RuleBase:RU010713"
FT TRANSMEM 143..162
FT /note="Helical"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT ECO:0000256|RuleBase:RU010713"
FT TRANSMEM 237..262
FT /note="Helical"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT ECO:0000256|RuleBase:RU010713"
FT REGION 432..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..490
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 501 AA; 58100 MW; BBE1EF0B91341ACA CRC64;
MECMLPMGFS GAWEQYAENF CWAQDTYFVP PKVFVEDISA EERRERRISY YQWMPFFLLF
QAACFKAPTL IWKYFAGQSG MKLGQILRLS SDPANSSLEV KKGNIEALCI HLQGALRFHE
RVKKKKLVPH KICRILNLKY ANYYVATIYI LAKLAFLANA IFQISLMTRY LLPELRNDYG
LESWINIIWP KNVSPSWHYS GIFPLVTLCD FEVREMGNIQ THTVQCVLVV NLFTEKIFIL
LWAWFMVLAA LTSLSVFNWI YLLTENCSKE HFILNHLEMS GTPFDKNDPQ NKEHVDCFLH
KYLGTDGIFV LRMVANHADV VFATELIASL WRSHYVFEER RKNISQMDKV WPQHQQRLEM
ALLEEAETAR KISSDALNVL QRKRSIFFDS PYFVKRGSPT GVTIPKVPSR NILGSPCLLS
RNNSKDSIIP FSPRLGNHPR GSTFSTESQG KLRRRHSMED IDIGGGRVKF ADSSDEEDRE
KEKEKGPKSF NMTRKSSIKI W
//