ID A0A1I7VJV4_LOALO Unreviewed; 6809 AA.
AC A0A1I7VJV4;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Fatty acid synthase {ECO:0000313|WBParaSite:EN70_3320};
OS Loa loa (Eye worm) (Filaria loa).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_3320};
RN [1] {ECO:0000313|Proteomes:UP000095285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Genome Sequencing Center for Infectious Disease;
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Loa loa.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:EN70_3320}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
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DR STRING; 7209.A0A1I7VJV4; -.
DR WBParaSite; EN70_3320; EN70_3320; EN70_3320.
DR eggNOG; KOG1178; Eukaryota.
DR eggNOG; KOG1202; Eukaryota.
DR Proteomes; UP000095285; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0004312; F:fatty acid synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0046483; P:heterocycle metabolic process; IEA:UniProt.
DR GO; GO:1901360; P:organic cyclic compound metabolic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd00833; PKS; 3.
DR Gene3D; 3.30.70.3290; -; 3.
DR Gene3D; 3.40.47.10; -; 3.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 2.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 2.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 2.
DR Pfam; PF00109; ketoacyl-synt; 3.
DR Pfam; PF02801; Ketoacyl-synt_C; 3.
DR Pfam; PF08659; KR; 3.
DR Pfam; PF00550; PP-binding; 4.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 2.
DR SMART; SM00822; PKS_KR; 2.
DR SMART; SM00825; PKS_KS; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 3.
DR SUPFAM; SSF53901; Thiolase-like; 3.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00606; KS3_1; 2.
DR PROSITE; PS52004; KS3_2; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000095285};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 659..1058
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1619..1697
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2227..2306
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3065..3488
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 4318..4393
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4409..4804
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 5794..5869
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 610..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..640
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 6809 AA; 778668 MW; A25917D36FD5667E CRC64;
MACKNDSEGI TDVVNIAKRW NDHSKIPKQQ NKCEGQGRSK MTKGHIWNKW DNEWQQNKSK
RLDIKSEQKD DERWKRNGKG LKFENQTNIE SSMVRNQEFK NNKGVEKIEW TENFQIPGLM
INIERKCTLT LSSIQILSDI FEEYHTHCCN AFHISPNDTA IETLEQYAAI TYAIIRLLFR
IGYNPERIAV SGLDTLIILA AKDAMKLENA CFAWKFIASL IKDDDNPAIV EQINAILLKL
DINFLKTTSL INLQQLSLLD TESLTVAILT NDEENQQFLT GSMEPYVIFR SANNYSVKYI
EKFDDSRTSI IFQKDSELLQ SLQKTPIQEK KLLEQNTVEV IDVQVNLKKE KYLFSHLIHN
YNILSAATLL NTIYGALTNQ RCILIKDATF LFPVTFKPDN EIINFKIRIS AEICTVIYVN
HQCVTFRFDK LYQGIHSGDS NNEESQDINC TIDRLRTGSV LDAKLVIGKE FYAQMEQYHY
QYRKEFRCVR KLTINKDSGT VELTSTEHLD ILIDGAMQAI VFILIQQYHT KLITLVPFHI
RRMNIVNITE KAITTGKCND ANNIMAFVKA KLQNGQLLGS FEFVTDKIAV SANAISFYPM
MPDKMIKSSE KERVLSSNSL KSKTDSRHKA TVKPETEESM NKNELSQMML NNALMLQDKS
LICIKSIACR LPKTVHDPAE FWDALKTGQI MANKIPCSRI NGRDNLARGE YGHPVRCANF
LTDDISHFDA AFFGISRSEA EKIDPQQRIL LECVYECMEN AGLTSLKDAG FFIGFMSNEY
PDIVKSRDAV SMLGSSASIV SGRLNYLFGS TGPSITLDTA CSSSLVALQA AIHALHNGSC
TTAIVAGVNL IMTEQSIGQR ANGNLLADDG LCRSFDALAN GYGRADGCVV LLLGITDKAV
ERNDYAVSIV STCIGHNGQS ISLAAPNGYA QEKLLRDCLS KIQGNQSVKY WETHGTGTII
GDTIELKALQ ANLQHCLIST VKTHFGHSEA AAGATGLAKI LLQFKYEYIP EHGSYQCLQN
LQDGNLYLPI IGEEWMDTLA GISSFGISGT NAMTVLRSKK ITLKRSKKKI MTKWQTYICP
ISAKSKESLD MLMISYQTMF ENTFQNIKDI CSTAAFHRNH MQYRAIILLY KGKIMEQWMN
DEKFWKQEAI GLKLYSNSCL YVLPWFYSIF PKFRMNFKIY FALMKNFAMQ QISAKFQQTR
SIVILAGFLS IITFLNDIGI ELKAIHAYDS LSLTAAYLIT GKLEFTEVKN IVNSNMQIFT
SKISTTNKYI GNYKWYKLDI INDRKIFEYE LMKMIAITYL RGDCINWKYL YSFSFHSITL
PNYQFKRESY WITKNSSTID HWLNGRLIKE EKDECIFINQ ISKMISAKLL AFKYDGQMRF
TFGICCEAII QALQLTFLKN ITEQSQHYFF NNLTMIKYLV QENDWIKTTI KRYEDKNYHV
KLTCASNIIC EANIMLTDYK LTMNGLNITQ IGNFITKANF YEILNDKGIF YDGIYQTIIR
ASSSHKIFVT KCYCQIFLIV ETIIQVACYC DILNPSDIYN EKKFIIENLN FHMFLSELMY
IRIENGKIIV YNGNDYRMMI SVNLNDKKVN EKYDKIKWRK EKDETKFDQF INFSSTTYQE
YTDKIRKAVE DIRKDDSSIS NEQLSATFIE LGLDSLAITD LANRLNTIYF PDLQIGAVDL
FNYPSIYLLT NAIYTRKISS RIIDDKEEKV RQMNDTSYSD MLDKKVRQMN DTSHFDMLDK
STLKETRSQE KHSLSVMDED ESCAYEQIFL EQQLRNDCMT VIITDKRSIS ERKSANELII
IVSNKTRRRS SHDDVGILYL NTRNPENFKH SFLLHLNDHK TVLIKFELSS NFPLRYLTEV
LLHLTKNIIQ SKHTYAFSSK PGFGRANGFA LGFAKSLCAE FYPKVQYEWN FILKKILNLK
KYVEEMPKRN DMNSKERWLI TGGLGGIGWQ IAKFIGYNRK VSHIFLLGRK EPNKIQSREM
NKMHDSVGVD VRAVSVDLTS KIQMEEFFDK LQISLTGIIH SAGCIHDALA SKQNLSTFRL
VTEAKCDGLV ILEKLCHSHP IKHFIVNSSI SAIIGNRGQC NYSAANAFID EIMLERRAKR
LPATIINWGN WLEIGMAVKA NKILNKMGFI GLETRKAMTY LQIAIDHAPA RMIVTQIDVR
KILHYRPDLA VVFRNNTNGN NTLTARKNIP EQSLNQRNHL YGNQSTNGIL KQWSKNVEAN
GGIDCKNNIH YLKSEIAGIL ETITGEPVTI EDYQRSFMDL GLDSLKIYRF LSELTGRIEI
KPLLNVLTIF EYPTINKLSH HIGSLFCRIK EHPEKMTTDD NFRSKNAENL ENIAKNFEIF
VFHSKNEEKL GEEKRHFLDL SDQSRISEIL SDRSFAHDQS NNHLHIIWGS KYKILRNKFL
HFESIPNIKQ SRKPIICFMV SGQGSQVWNM GKQLSCIFPF FRKIFNETLD IATRYMPKKS
VNIRDVIYQW NHRELLHKTE YAQPIIYCFA YSLAKLYEYC GVKGTFFVGH SVGEIVACTL
ADRISLDHAL KLVIRRGEIL RYTEGKGKMI AVKANDAKKL QQYSGMNQAA INSNKQIVLS
GDNQSAKLCL HFARLHQCSV TVIDNCYPFH SSAIDDTLLD QYRIECKKMK LQKTKGRNIV
SNCTGQFMDS TTKTIASIKS TVFFKRCVET LDDNNTNIWL EIGNGEILTS LVKSMMGSAS
DTLICPAIRN DKQEMDSFIH SLCQLQIFGV KIKWDRICNR TSTQGIMKSY EKKITKKLID
EKEKDLELIE EHLIHGRITL PAAFIITMFA EFAINSSEKC ISKSEVISNT REKLTFERKT
IIFEALRLEK RVNEIDLSKL EIKFHSPELI LTDNISKYSS CRLGNEESKK IRQRTSTLNK
LRIKYEQLKV KMEKLPHQAF YETMRRYGLQ YGLKYQILRE IYRKDYYIGG TLINADNLTQ
LLDGALQLLS AALLVTNKSS IYIPFAIDDI IIKYDTKTAS NCFYAYGIIS KRIDNIIKGT
VVIYENDNQI IILHNVTAID ISTNKSIIST KHRNSSDSQC STSRKMKRTA IKDKTDSIRH
NLNNADNTAI MEMKRHNKSS ARNDTLQIEI ISYVGQFPDS AVDCASLWNN LKAGISLHSS
GNIQKLQTDV TIFDPVKFGI TPKEAAYIDP QQRILLEMTQ KTIEKAGLER LDSDTGVFIG
VSSSDFAQKA YKEIQDTCSY LSTGTNQSAL AGRIAYWFNL KGPTMVVDTA CSSFLSALVV
ACDNIRMGNC RAALVGAVNI ILNSKSTSVL ENAQMLSKIG CCKVFDVDAD GYIRSEGSAM
ILIQGTNGES HNSSSETLAM YRNDMKFTIE SYGMGHNGRS NGLTVPSGIS QYELIKRVNR
KRVNALTISW VEAHAAGTPL GDPIETKAIV RALADTSYTD QPIRITSVKS STGHCEAAAG
AASLIMALEA YYHRYLPPMQ HFKLLNTNIM NNAALIVPVI GEELPDTFDM LINNFGFSGT
NVSIVIRGCN RRQLKQNEKA PNQPVMKQRL SSGHSPCILL CSGDDSESFK LVSEKLDDYI
EKTSHSLVTV CACLQDLRNT GRYRTAMLIK RHTQKWLSFR MSNKPQKWTK VVFSMGKSPK
PTMIAELCTV YSSFRKIFIG YIRTYKCANS FTSSKSGGQI AFEYISKLSL VTFLLTIGIN
PSIIIASTRI DRIVAEVVRR KYKVKYRFEA KNTFNKGMPY NRRNFEIQRE MVVEDFDCIL
NMQTLRIEKP ETACNNNWKQ SFINQFVDTI CQLYEHFIDI NWQMLNDRTT KTCLIPDPEY
SKKKYWPFTD CNMQNTDYNP SYGEVPLPSL QLEMSQKMEK LDETNPMADQ FNSNNFGNTK
TDLTNCQYLY KLVRKKCILP NPERIIPFIA INLTDITTII GQQAIFIGKI NDNDNIAEVI
KQVDLHKCTK LILEWVIDEE NLMENSIKQS MLVINLWKIL VNKSRNNNNN DNNNNNNSND
NNSYRNTNEK LCLIVFATIN TTKEDHHRSF APAPFSALLK TLAMEQTNVN FKSIHTDIID
QKLFHEISDE NFLNEVIYYN GGNRYVERLQ QMDSTELIKQ QMKNIDRILI TGNIRGIAGK
LTEVLRPHLA VVVSRTMPNT CNNDENGSMV RTIQADCTDY KQMERIFATF APFDVIFHCA
AVINNSLMEN MNLKLFEMVC RPKVIGLQNI IRLSRLYPIR KLVVFSSAAT ILGSAGQANY
VVANELMEYL MRKNIPDGLF ISWGPWDGRG LLVGEHMTGI RKQIQNIGWK LLEVQQVAQL
CCKLLSSTGH HIAMDVNFDM LRKKRSYLRN FLENIPDNNF NIHKCERSFP NDLHSDSKSG
KDFNEIIKNC ITEISGITDV KPDLGFMSMG IDSLMISEMQ AILNEQLNLN IPVAIFYEYS
TVETLSQYMA QSIATNCKLQ NDTKAKDKND KVAIIGYSGA FSGVPDDEIF WRSLLDGKEL
IEHHKSDNDE TVEAIGIVPD IDKFDYRFWK MSPDDASYID PQIRKFVEHA YIALERSGLI
RFRHKLRIAV VVGAEPSEYR PKSRRIGGIE DLYEMNQKDF VAAWTSYLLD LHGPSFGVYS
ACSTALVAII QALNLLRKNQ CDVALAGAVS LSVPRTNNNG NLQGMVLSSD GHCRPFDHKS
RGTVRGSAVG VVVLRRLSEA RQNNAPVIVK VTGYGITNDG LLKSSFMAPN ISGQRTCIKE
AIEMTGTAEM DYIECHGTGT TTGDLIELTA MSQLYHRDTL IGSVKANIGH ALAGSGIAAI
IKLCKIAEMR VIPKQINFDK LNENLKDVSF KISQRNIEFQ KKKLRLAVNA SGIGGTNAHI
IMENDNHISS YQSNTKQYFY VLTISGRTKN ACIHLCDRIA DYLKPEMNLT QVASTLQNYR
EHFEYRIGIN VQSAMDAINQ LKNITKIQKM IKLKRENVAF YFAPQGQEYF NMGLEVMAYN
EVFRKVMENC CRIATKLIGM NFQNIIHPQH QFDKQNIIAE QPYSQMATFI VCFALAEQLK
AWGIEGCIMI GHSLGEYVAA AQADVFDVET ALKILFKRGC LIAKTERVKM VAVKCSKFTA
DLSLESTDGK YFKIPETIEV SAILSSDLKC LVGKPETIEE LKKEMKEDGM NYRELMTNYG
FHTSFMDLIL DEFAQFLENF TFRKPTKQIL SNIDGQIIKY FDSKYMVKHM RSAIRIDKCI
DNLHNEIKAI IEIGPKGILE SLLKDNNSCE IEVISTLPSK KQHEKGYDTG DLFSVVTKLW
MKGYEVNWEK ICGNYGFDRL LPNYQFEKDI CWEYQEKEWN TERLNVNLYE SCWIPYKFTN
RRRLPKGILL FLPRIITKPI NTLLTILHNL FVPVRCIFSD TLSSGNVNVI NGNVYINSNN
EESYQQLASF LRNGDFHYDT IIHAWNFPVN HETERTNDSY LLSSFYSIYW ILANVIQNST
DLRLLVSIDW DAEPELFTVL GPIRELAMTK RSMKAACILC TPEVNLFEGL QLLESYPADF
LLIRNSINGE FEHFSYKLKP IENDNYSTGN QDRSIDENDC LVQSADVVVI FGFGNIGQSF
VTVLCQNFDF LTIYLVSPNA TRHFQQFQNK INQWKTSRKF KMSEKVNITN VPVTDVINDQ
HTIHAYDVDI TKKEDIQHLL TQIMSQHGRI NVIIHAAAGK IDSTKFEKNF NEIQSIFQPK
IRGIRNIIDT LHGNNIHIRS LILNSSMNAL FGLPGNTDYA ASNIFLDACC CRRNFRNIQN
ITTIQWTGWK DSNMLGYYMN KENKSQNPVT DLIIEYSLSL EEAGQMIWKC FHERGLIAVS
SVSPNDIIRE IRKLNFMTSR KFGIIPEQEK TVEKNCNDLR NIIAKIWMDN LGVEQVTYHD
DFFQLGGHSL NGMQIIWEIN RMLQINCKLD DLFQNSKFEN FLKFLQKFVI KEGEEKFNLE
IFKIIDSTGK LKRIPLSYPQ ENMYILRQLQ HPTLYNVCFL LTFQGLICIK SLRKALLFLI
ARQTSLRTAL SVLNDSCYQE IKSLTESYYH ITWPNMNELE RRKLIKDEKN HAMDLSQIPF
RILPMCNKES DNVEIEYLIM ISQHHIITDG WSMTIFANEL GKLYHYCLIN QRIPETLKRL
SRDVTHFAVW QRTNEFTKTI QNDLQRLCAK LQGLQATRIM AQKTANIRSK LISQKIFSIP
TSLWAQINQT AKEYQQTTYT VMLTAFLCLI RKFSDDYSNN TIVIGCPVSG RTDAEEMKSV
MGYFLNNIIL IVKDFKPNAP NNVLFEKVKE AIQEARSFEH LPFHLLVANL SHQRRHAYQH
PVFDIFFNYR HNLDFPEIEI SDVRSTITQL TTNNAFDFAC TIDETNEGTL ITVDYNANQY
SIQLIDTMIT VYFKLLKSFN NQSNGLRNEM NDMRCRINRD MISGSLIDII EQQSTYTDKL
IAIYLSHQAI TYRQMYGMIH IFCMKIKQFY LQNNCENIRA DTIIPICADS NAIIVPLLAV
QLTGAAYAPI DPTNSTTMIK QLVDDIRATV IIVQENNFDL NIPTLSLSHF SPLLNHAFYD
NEGYERLEKE DIRKSIQNSD ISYVIFTSGS TGKPKPVCVM NRNLLNFVLA STQQASFRPN
FRIYHSVNTI FDVSCVNIFT TLSNGSCLIS SENILNASVE IIQKNVQFAF LPSALFNMFD
GNEINQFQQL EKLYVGGETP NNEQLNRCLQ MGIPVRQIYG PTETTVWSLS NNCSVAEYEC
GRVIGIPIDN EIVYLLDSEN NITYNGGNGE LVICGEGVSR GYLNQKRNVF TFNKFHSKED
QILNRNIFCY HTGDFSMKLG EKYHFIGRKD KQLKIRGYRV ESVAIEIIVR QWDSSIRNIA
VLKNDRLDNL FYLLKKIPIT NTVKNYDNI
//
