ID A0A1I7VM56_LOALO Unreviewed; 467 AA.
AC A0A1I7VM56; A0A1S0UKA3;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=ANK_REP_REGION domain-containing protein {ECO:0000313|WBParaSite:EN70_4053};
GN ORFNames=LOAG_16844 {ECO:0000313|EMBL:EJD76142.1,
GN ECO:0000313|WBParaSite:EN70_4053};
OS Loa loa (Eye worm) (Filaria loa).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_4053};
RN [1] {ECO:0000313|EMBL:EJD76142.1, ECO:0000313|Proteomes:UP000095285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Genome Sequencing Center for Infectious Disease;
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Loa loa.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:EN70_4053}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004211}; Single-
CC pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004211}.
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DR EMBL; JH712088; EJD76142.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I7VM56; -.
DR STRING; 7209.A0A1I7VM56; -.
DR EnsemblMetazoa; EJD76142.1; EJD76142.1; LOAG_16844.
DR WBParaSite; EN70_4053; EN70_4053; EN70_4053.
DR eggNOG; KOG0504; Eukaryota.
DR InParanoid; A0A1I7VM56; -.
DR OMA; IVQFCVS; -.
DR OrthoDB; 2543462at2759; -.
DR Proteomes; UP000095285; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005484; F:SNAP receptor activity; IEA:InterPro.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005606; Sec20.
DR PANTHER; PTHR24171; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF03908; Sec20; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 5.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 4.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000095285};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT REPEAT 304..325
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 338..370
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 371..393
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 405..437
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT COILED 75..102
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 467 AA; 52670 MW; F7AEAC497F6ABDFF CRC64;
MQNLNLVQLQ VCQQDILKAD IAVKNHIEGI RQQKFMSQKE IAQCTRDIKD EIAKLGHLID
TLEKFANKIT FRNDRVELLA QVKEHRNELE KNRQMLRQAI LKFVKVMEEQ SLSYLLQGGD
DSQDIEFRNR RRRGENLKTQ TLKATENLAS LVTKMSDQLK LSEDTTSTLI HSSFLLKDTE
SEYSSMGAHI QSGGKLISKY GRRECTDKIL LTFALLLYVV VIFKLMNGKP AKTLETARVE
LIESLRKNRA EDAKRLLQKF DTLRSGKDDS GRTAVHWAAS GGCLEIVQFC VSQQESDAIA
MDDMGWTPLM IACSAGRLEV VRYLITLPLV NVNTPNNNKQ TALHYAASKN RPQITTILLK
NGANVNAQDN YQATPLHRAA SQGHEKIVPI LLNEPSLRIN ITDSAGCTAL HLAVEEQRED
IAILLAEHGA DLYSENKEKQ TPLALVKTSE LQMKLKAAAY RYLSKTR
//
