ID A0A1I7VM73_LOALO Unreviewed; 441 AA.
AC A0A1I7VM73; A0A1S0U0F4;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial {ECO:0000256|ARBA:ARBA00017279};
DE AltName: Full=Complex I-42kD {ECO:0000256|ARBA:ARBA00032828};
DE AltName: Full=NADH-ubiquinone oxidoreductase 42 kDa subunit {ECO:0000256|ARBA:ARBA00032628};
GN ORFNames=LOAG_05118 {ECO:0000313|EMBL:EFO23371.1,
GN ECO:0000313|WBParaSite:EN70_4113};
OS Loa loa (Eye worm) (Filaria loa).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_4113};
RN [1] {ECO:0000313|EMBL:EFO23371.1, ECO:0000313|Proteomes:UP000095285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Genome Sequencing Center for Infectious Disease;
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Loa loa.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:EN70_4113}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000256|ARBA:ARBA00003195}.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC {ECO:0000256|ARBA:ARBA00004305}.
CC -!- SIMILARITY: Belongs to the complex I NDUFA10 subunit family.
CC {ECO:0000256|ARBA:ARBA00008606}.
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DR EMBL; JH712099; EFO23371.1; -; Genomic_DNA.
DR RefSeq; XP_003140703.1; XM_003140655.1.
DR STRING; 7209.A0A1I7VM73; -.
DR EnsemblMetazoa; EFO23371.1; EFO23371.1; LOAG_05118.
DR GeneID; 9942521; -.
DR KEGG; loa:LOAG_05118; -.
DR WBParaSite; EN70_4113; EN70_4113; EN70_4113.
DR CTD; 9942521; -.
DR eggNOG; KOG3877; Eukaryota.
DR OMA; CRFDQYL; -.
DR OrthoDB; 6357at2759; -.
DR Proteomes; UP000095285; Unassembled WGS sequence.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:InterPro.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031314; DNK_dom.
DR InterPro; IPR015828; NDUFA10.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10513; DEOXYNUCLEOSIDE KINASE; 1.
DR PANTHER; PTHR10513:SF15; NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 10, MITOCHONDRIAL; 1.
DR Pfam; PF01712; dNK; 1.
DR PIRSF; PIRSF000543; NADH_UQ_42KD; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Electron transport {ECO:0000256|ARBA:ARBA00022982};
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Kinase {ECO:0000313|EMBL:EFO23371.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000095285};
KW Respiratory chain {ECO:0000256|ARBA:ARBA00022660};
KW Transferase {ECO:0000313|EMBL:EFO23371.1};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 81..317
FT /note="Deoxynucleoside kinase"
FT /evidence="ECO:0000259|Pfam:PF01712"
SQ SEQUENCE 441 AA; 52194 MW; FFEDCFCEE6D5D9CF CRC64;
MAGALCKWVH TGHRLRTSSS SVFGGIVQFV SQKRTIVKKS KLKLDPDTYP KPWPYKEKGY
RWQHVLVDRT LKRFHENSKL IVVEGNIGSN KSDMARSLAD RLGFYFIPEF QMDEVLIDRF
GNDYRNYYHL FPKSFRLFDM NMFYKDPFND ETAKMRDRIL RCKFDQYLNA VAHVMNTGQG
VVLERTPHTD FIFANACRVK NYIGPEYFTY YYIERKNMIP NCRFWPHLVI YLDVPVDKCL
ENIRQKGSTD KIAVVDRTYL QTIEDSYKDA LKEFRKHSEI LVYDWTTPGN VDNVVEDIED
MDFDFFEHHK SDVFGTWENG KNELDYSIAR NFVTDKREAH ALAFLGLPEH ECGELYQSPR
ELGRYIQCIH NEILKTPYVY SAIKNKGDKF GWFSKISTFT KGEPWFQYYY KDAYLEDLVG
VQEVISDPTH QSYYNQIHNE H
//
