ID A0A1I7VM81_LOALO Unreviewed; 1578 AA.
AC A0A1I7VM81; A0A1S0UK19;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE SubName: Full=Bromodomain containing protein {ECO:0000313|EMBL:EJD75925.1, ECO:0000313|WBParaSite:EN70_4118};
GN ORFNames=LOAG_17009 {ECO:0000313|EMBL:EJD75925.1,
GN ECO:0000313|WBParaSite:EN70_4118};
OS Loa loa (Eye worm) (Filaria loa).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_4118};
RN [1] {ECO:0000313|EMBL:EJD75925.1, ECO:0000313|Proteomes:UP000095285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Genome Sequencing Center for Infectious Disease;
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Loa loa.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:EN70_4118}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WAL family. {ECO:0000256|ARBA:ARBA00007444}.
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DR EMBL; JH712099; EJD75925.1; -; Genomic_DNA.
DR STRING; 7209.A0A1I7VM81; -.
DR EnsemblMetazoa; EJD75925.1; EJD75925.1; LOAG_17009.
DR WBParaSite; EN70_4118; EN70_4118; EN70_4118.
DR eggNOG; KOG1245; Eukaryota.
DR InParanoid; A0A1I7VM81; -.
DR OMA; GMIMWER; -.
DR OrthoDB; 2919186at2759; -.
DR Proteomes; UP000095285; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd05503; Bromo_BAZ2A_B_like; 1.
DR CDD; cd15545; PHD_BAZ2A_like; 1.
DR CDD; cd15489; PHD_SF; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR037374; BAZ2A/B_Bromo.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR028941; WHIM2_dom.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45915:SF2; IP14655P-RELATED; 1.
DR PANTHER; PTHR45915; TRANSCRIPTION INTERMEDIARY FACTOR; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF15613; WSD; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS50016; ZF_PHD_2; 2.
PE 3: Inferred from homology;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000095285};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 334..406
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 656..720
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT DOMAIN 1281..1331
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1335..1390
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1464..1534
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 82..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 124..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 517..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 845..871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1419..1438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 897..928
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 83..102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..334
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..560
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1578 AA; 176575 MW; 93467D30A8207EB8 CRC64;
MGDQAQQNFL ALLAAQAATQ NNMPMNLLFP NLNFGMTNTV DMMFWNMAHL SQPGLLLQQQ
QQQPQESFEE VLRRMATASA RSANIVADRQ QTNRGTDNAD NNELTLRATG HFVADIASTS
STNVGILTSV PDSPTKGLEP GEIPKRRDSN RTRNGMSSQL SPSSSSSSSS VGGVSLNSNL
LEASARCYAA LAATASQQHQ QHSELIAAVL QSAANYERAR ARVATTSTVT TACPSGSSSS
NSTHILKRTA LTHQHASSGL STCRKEEGLR SCAVSTKISS HESVLTSPSS ARLTDSPLDL
SFHKPRNGTT GERGRIFSEH TSGADSDGSR KRTQADASLI RIPLKSGWRR QTCIRTISAS
GVRGDVIYYA PCGKKLGSYA EVTRYLTKKN IKDIGRENFS FSCKVIVGEY ILFKDDEDGS
KVPDRVSEER ILAEIANCSA TNTVRRTSGT HMKATLSSGT TDLPGTVAPS ADKNLLKLTE
DNALKQLHRQ LLRRQGEQQM YAQLLLTFGQ HVQQQQQRHF HQQQQQQQKQ QPSLITVEGK
SAAEVEPEIK RPKIDESEST TSRHTTPSVI PVATSLISST ASNIIPSHIV TTTTTAAVAG
STAPATEVKL PKLELSEEEK QEERLKALRL PTDDLLIEEA RKLPTLDSIE NLSVSASTFA
NVLMVDEFIR NFGHVLKIDL NAIPTLNEFL AGLQNHPNYI KGFLLLTKIL LQLVLEYPGL
PSGIAGRTPL GQALKDVGVH RENYSELLKM FLLSRDEEGK KLGTKLEYCS FECLDPESKA
AILAFLCNEL LYCRNVVRDI ESNMEEMTRL KGEKWLREGK SRALRAVQTR KRAALKRLRH
DIRDDDTLSS RAGTPGSEPS DVSEEVEPAL QPSRLKALTP GLGQCDVLTE EEEAMTVDEL
DEYIGKLNNE AEELRERHNT LINRVRIQPI GQDRFHRFYW ILPRLGVPLV ESIASSGLHN
PAVNVDITCR QDPPSIAEDP QNFIDPNVIA CLEDILDTLC GNEERPDRGK KVRLRRLDNK
CKRGWWMISN GKLMEQLRGA FHGRGIRERV LHRLLIKDNF TFNPSTQLKL ERVSRPLTNN
EINKAMIIRL AALISSFEQK VVAANIHCRP MFPTGDNRDD DTESEDSLDA WTLDDGYVLT
DEAEINEDCP LFEWDNFKAL KVRLLEVEKS IERRYLLHRY YAGSTIPAEK ILRTQQQNNQ
NGSSADTSSI VDVSEVQSET SDSINSNCPF DGAAITVDES GNTELLQRWR NYVQQAKTGG
QIMFALQALD SAIAWEKSIM KASCQICRTS ENESQLLLCD ACDMGYHMYC FRPRIATVPD
GEWYCPLCVQ RACRKVLCLL CAKWNRPNSQ PLEPIIVCSK CYNGYHASCF DRSPTLNDPK
QWTCPGCLNA DGFSTELANS LLNGDVEIAL AQQEGQEKQT GCVQEDASGR QEAPRHRRRM
TPADYDFPLD MMKNLFNTML DELWARPESG PFQYPVDTKE VPFYKKVIKR PMDLNQMRMN
VENNKYITQE SFIEDLEQIF ENCRTFNEDE SPIGQSGVTL HKFYLKRWKQ LRYNYSKRLK
RLKNPRLVHS VTLLSSSS
//
