ID   A0A1I7VM85_LOALO        Unreviewed;       449 AA.
AC   A0A1I7VM85;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=VWFA domain-containing protein {ECO:0000313|WBParaSite:EN70_4097};
OS   Loa loa (Eye worm) (Filaria loa).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX   NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_4097};
RN   [1] {ECO:0000313|Proteomes:UP000095285}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA   Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA   Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Loa loa.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:EN70_4097}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
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DR   AlphaFoldDB; A0A1I7VM85; -.
DR   STRING; 7209.A0A1I7VM85; -.
DR   WBParaSite; EN70_4097; EN70_4097; EN70_4097.
DR   eggNOG; KOG1217; Eukaryota.
DR   Proteomes; UP000095285; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   InterPro; IPR001507; ZP_dom.
DR   PANTHER; PTHR22907:SF47; CUTICLIN-6; 1.
DR   PANTHER; PTHR22907; UNCHARACTERIZED; 1.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00241; ZP; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
DR   PROSITE; PS51034; ZP_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095285};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        419..443
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..108
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   DOMAIN          125..368
FT                   /note="ZP"
FT                   /evidence="ECO:0000259|PROSITE:PS51034"
SQ   SEQUENCE   449 AA;  50747 MW;  5A9F00FC8FC41190 CRC64;
     MEWAIQRIKY LSGATNTGAA LKFALERGFQ DARGGGIPKV AIVVTDGQSQ DSVAESAQQL
     RDAHIMLYAV GVTNLVNVHQ LHQIAGNPAR VLTVESFDEL SRTLADSLTW DMCKTEFRPG
     TPDIICGPDR IGVRASTKNP FDGYVFIMDH FHKKECRAGP EEFPDARSIG ITIPFTECNI
     HRYRSLSPRG IFVEMTVIFM FHALFMTKVD QMVKVQCFYM EADKSVSVPM EVSMITTQFR
     EKMYEMPRCE YTLRRGSQDG PIVQYAQLGE SIYHRWECHD QADTFGMLVH SCYVDNGFGD
     RVDILDDTGC GIDTVLLMTP DYDETLRLAT KPYHVFKYAD RPITLCLKLD AGCIGLTPPN
     CPELAHNHMH SHDHVHEQNE IRRARSILES NTLDIFTPQL HIVDNLPQCP NHSIQFPSLY
     IVVVVISVML NILLSIIIAM RFLKSKKNG
//