ID A0A1I7VMN3_LOALO Unreviewed; 238 AA.
AC A0A1I7VMN3;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Bax inhibitor I {ECO:0000313|WBParaSite:EN70_4258};
OS Loa loa (Eye worm) (Filaria loa).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_4258};
RN [1] {ECO:0000313|Proteomes:UP000095285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Genome Sequencing Center for Infectious Disease;
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Loa loa.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:EN70_4258}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the BI1 family. {ECO:0000256|RuleBase:RU004379}.
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DR RefSeq; XP_003145711.1; XM_003145663.1.
DR AlphaFoldDB; A0A1I7VMN3; -.
DR STRING; 7209.A0A1I7VMN3; -.
DR GeneID; 9947578; -.
DR KEGG; loa:LOAG_10136; -.
DR WBParaSite; EN70_4258; EN70_4258; EN70_4258.
DR CTD; 9947578; -.
DR eggNOG; KOG1629; Eukaryota.
DR Proteomes; UP000095285; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR006214; Bax_inhibitor_1-related.
DR PANTHER; PTHR23291:SF122; BAX INHIBITOR 1; 1.
DR PANTHER; PTHR23291; BAX INHIBITOR-RELATED; 1.
DR Pfam; PF01027; Bax1-I; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU004379};
KW Reference proteome {ECO:0000313|Proteomes:UP000095285};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU004379};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU004379}.
FT TRANSMEM 32..54
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004379"
FT TRANSMEM 60..76
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004379"
FT TRANSMEM 88..106
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004379"
FT TRANSMEM 118..136
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004379"
FT TRANSMEM 143..162
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004379"
FT TRANSMEM 168..187
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004379"
SQ SEQUENCE 238 AA; 26987 MW; 9FD69C075EA181BD CRC64;
MRDDSDIFRN VRNIFTSLND KLEKDVQEHL RAVYGTLALG LIAATFGALL HLFIDFLHDN
FFLLFGSVLL MVAILKTPHT VYNERKRFGY FIAFCALSGV GSGPVIEKAL VVDPSTILTA
FLAAAVVFSC FTMAALYAPS TKFLHLGGII TSGLFFIMMT AVFSHSALMH TTCFWLAFVI
NCTLVLYDTQ LICEKRRRGD TDYILHTIEI FIDFINLFRY ILAILSEKKE RTNRKRND
//
