ID A0A1I7VN71_LOALO Unreviewed; 644 AA.
AC A0A1I7VN71; A0A1S0UIJ1;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 6 {ECO:0000256|ARBA:ARBA00020973, ECO:0000256|RuleBase:RU365075};
DE Short=COG complex subunit 6 {ECO:0000256|RuleBase:RU365075};
DE AltName: Full=Component of oligomeric Golgi complex 6 {ECO:0000256|ARBA:ARBA00031348, ECO:0000256|RuleBase:RU365075};
GN ORFNames=LOAG_18017 {ECO:0000313|EMBL:EJD74707.1,
GN ECO:0000313|WBParaSite:EN70_4427};
OS Loa loa (Eye worm) (Filaria loa).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_4427};
RN [1] {ECO:0000313|EMBL:EJD74707.1, ECO:0000313|Proteomes:UP000095285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Genome Sequencing Center for Infectious Disease;
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Loa loa.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:EN70_4427}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- FUNCTION: Required for normal Golgi function.
CC {ECO:0000256|ARBA:ARBA00003627, ECO:0000256|RuleBase:RU365075}.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC composed of eight different subunits and is required for normal Golgi
CC morphology and localization. {ECO:0000256|ARBA:ARBA00011166}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004395, ECO:0000256|RuleBase:RU365075};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004395,
CC ECO:0000256|RuleBase:RU365075}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the COG6 family. {ECO:0000256|ARBA:ARBA00011023,
CC ECO:0000256|RuleBase:RU365075}.
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DR EMBL; JH712239; EJD74707.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I7VN71; -.
DR STRING; 7209.A0A1I7VN71; -.
DR EnsemblMetazoa; EJD74707.1; EJD74707.1; LOAG_18017.
DR WBParaSite; EN70_4427; EN70_4427; EN70_4427.
DR eggNOG; KOG3758; Eukaryota.
DR InParanoid; A0A1I7VN71; -.
DR OMA; HSCLDFF; -.
DR OrthoDB; 276556at2759; -.
DR Proteomes; UP000095285; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR010490; COG6.
DR InterPro; IPR048369; COG6_C.
DR InterPro; IPR048368; COG6_N.
DR PANTHER; PTHR21506; COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6; 1.
DR PANTHER; PTHR21506:SF0; CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6; 1.
DR Pfam; PF20653; COG6_C; 1.
DR Pfam; PF06419; COG6_N; 1.
DR SMART; SM01087; COG6; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|RuleBase:RU365075};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365075};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|RuleBase:RU365075};
KW Reference proteome {ECO:0000313|Proteomes:UP000095285};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365075}.
FT DOMAIN 53..157
FT /note="Conserved oligomeric complex COG6 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06419"
FT DOMAIN 194..640
FT /note="Conserved Oligomeric Golgi complex subunit 6 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF20653"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 644 AA; 72574 MW; 9489CB7581320383 CRC64;
MSTHGGSIKP TSNSDPSNPI RKKVESLVSQ KLHTDQDFLK MMDYVAPIVK EIDIHVERKL
VYELEERKIK ANREYMKAFG LVNDRVQDFV AKVMQLNGIC QDMTHKIQSN KAKTQDLLAR
TAALQNAKRT LEKKQVAIDD FLSRYSLAPE EEAALKGSEA DGTVDTKFFA ALQRVKQIHD
DSKQLLRSSG EHLAALDIME EMANKLEEAY EVLYRSIQRE CRLLNVEFLE LKGVLVQSVA
ALQDREVLFK YVLDEYTTAR RNHVVRAYID ALTRGGAGGT PKPIELLSHN PLRYVGDMLA
WIHQAMATER ELLQALLKLC RPDVLKENSI GMQSQISEAL CRPFKVRVEQ ALTTETNCIV
LYRLSCLFAF YLETMASSLN LDSMLIQTFK ELKELTLNLF FSGLHSLVQK LVGKIGTPDY
DLLPVSAVHQ ILVLLKDVLE SHDGAVVAVA DKKENFEKIF TAVLDPLNQA VQLSATQLHS
PIDVAVYTLN CLSAVNAAIV LYQFTDSRLE MIKAQIDANV DVLVSEQATF IMTQTGLIEL
YRKAAAHQPS QGALSEITGM EPSHISSTLF SFDSFLASPD KHKLDQWVKL SSARIRDTVR
ERTIETVLAA YRIIYNKLVD PSNKYPQLSI KTVEEVQELL KVWT
//
