ID   A0A1I7VQ07_LOALO        Unreviewed;      1120 AA.
AC   A0A1I7VQ07;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=VHL domain-containing protein {ECO:0000313|WBParaSite:EN70_5010};
OS   Loa loa (Eye worm) (Filaria loa).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX   NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_5010};
RN   [1] {ECO:0000313|Proteomes:UP000095285}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA   Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA   Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Loa loa.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:EN70_5010}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the VHL family. {ECO:0000256|ARBA:ARBA00010057}.
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DR   AlphaFoldDB; A0A1I7VQ07; -.
DR   WBParaSite; EN70_5010; EN70_5010; EN70_5010.
DR   Proteomes; UP000095285; Unassembled WGS sequence.
DR   CDD; cd05468; pVHL; 1.
DR   Gene3D; 2.60.40.780; von Hippel-Lindau disease tumour suppressor, beta domain; 1.
DR   InterPro; IPR024053; VHL_beta_dom.
DR   InterPro; IPR037140; VHL_beta_dom_sf.
DR   InterPro; IPR036208; VHL_sf.
DR   InterPro; IPR022772; VHL_tumour_suppress_b/a_dom.
DR   Pfam; PF01847; VHL; 1.
DR   SUPFAM; SSF49468; VHL; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000095285}.
FT   DOMAIN          22..98
FT                   /note="von Hippel-Lindau disease tumour suppressor beta"
FT                   /evidence="ECO:0000259|Pfam:PF01847"
SQ   SEQUENCE   1120 AA;  127614 MW;  CFAA826B193AEA93 CRC64;
     MSLSRSQVDS FIVKEIFNPG YRSIRNVEEV SIRFINNSHD TVDLCWIDFR GNLVRYLKLG
     SREVVKLTTF IAGHYWIARF VRNGVAAQFL PDHTEVFVTT RRFPHTAVVF IVQKVPTLFE
     AAVEHIGELF HEQQYALYKL PISELVKSMV LNDGKSKIKF KIPKKIDAGL FNKQEICSIL
     KDANSTFPQQ LMKIFTSGQI DLFLQAVSDL SVECSDFEIN EISLTYLRKE FVVMSSATVY
     NYTKKWIDFL LQNNSGARNH CLLLKQLICC TNLLQNNQLQ SLLHEVLPQA YRHLCFMKQF
     SSASVIAEVI FYSIALPAAY SDDCDREALR NVWNKLLLPE ESVRSAHFNL CTVLVMSSLG
     FGCAQYMQFL ENSLNDLKES EDLLFSNRKQ FHVLLEANLG VLLSHCQSNQ SELLLNILVT
     FHLENNDLYL LIQSVFRYSG LIDNYASKVL QPFFRCLLLR LSSFADENFP QQEGNVGIWI
     RKSVVEILSM SSKSYEDELN SWKMVISAFV PASHLMPLSE KRLCQIVQSV CGKGFSLKTL
     PVSLRVVLFC VLISLIPCIS SEVFEIVVES TLSIMRSDVK LFRSLINSCK EKTVKKYIKT
     LLRCGCLNNS SKNTQILVKE FLLSSCSCDM LALKCDVILK AAVQKSLIEE QYYFLKPLCE
     TFNEIHYEIN AGENRTLRIA TEKVFQHIYE LISPFDCMDT RKSALFELFL SVLSVVKILQ
     DNGTTVTERE IENTAEHIRI ADQVCKTLCK HPDKLIEFGI ISKQLSQLLR RSILWMVKRG
     KLEHIISWKY VRYFELYDES TVNDIISAAS MEMLESLLHS SSHDLHASEK FALYFALAKH
     QNEEKRKLLS SVLKDVLEVI VDIAGTDYLT TVAFLHHILP VASGSAYARD YVSFALTVLA
     VDYELLFSDP AALRSAVSLL LDCLRFGTNS IINDQCSFYM TLFVCVGRAI QKYVNDASAI
     SPRFIRHLSY GFAKVAGEML KYERSFSRVA PFIISECLED AECLSLALFR IFSICDGHSI
     LGVFYLIHME KCFARVQCKH TEVLVRLGRN ENHSVPICPS IVSSSHSKLE PKQLKQNVIR
     CDGLLCNRCR CDVKMGYKLS NNTSQAECVL ICPRHDSNGE
//