ID A0A1I7VQH0_LOALO Unreviewed; 844 AA.
AC A0A1I7VQH0; A0A1S0UL44;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=dynamin GTPase {ECO:0000256|ARBA:ARBA00011980};
DE EC=3.6.5.5 {ECO:0000256|ARBA:ARBA00011980};
GN ORFNames=LOAG_16654 {ECO:0000313|EMBL:EJD76420.1,
GN ECO:0000313|WBParaSite:EN70_5129};
OS Loa loa (Eye worm) (Filaria loa).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_5129};
RN [1] {ECO:0000313|EMBL:EJD76420.1, ECO:0000313|Proteomes:UP000095285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Genome Sequencing Center for Infectious Disease;
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Loa loa.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:EN70_5129}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. Dynamin/Fzo/YdjA family. {ECO:0000256|RuleBase:RU003932}.
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DR EMBL; JH712076; EJD76420.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I7VQH0; -.
DR STRING; 7209.A0A1I7VQH0; -.
DR EnsemblMetazoa; EJD76420.1; EJD76420.1; LOAG_16654.
DR WBParaSite; EN70_5129; EN70_5129; EN70_5129.
DR eggNOG; KOG0446; Eukaryota.
DR InParanoid; A0A1I7VQH0; -.
DR OMA; MQMVQTF; -.
DR OrthoDB; 1052588at2759; -.
DR Proteomes; UP000095285; Unassembled WGS sequence.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd08771; DLP_1; 1.
DR CDD; cd01256; PH_dynamin; 1.
DR Gene3D; 1.20.120.1240; Dynamin, middle domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR019762; Dynamin_GTPase_CS.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR000375; Dynamin_stalk.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR003130; GED.
DR InterPro; IPR020850; GED_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR11566; DYNAMIN; 1.
DR PANTHER; PTHR11566:SF212; DYNAMIN; 1.
DR Pfam; PF01031; Dynamin_M; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF02212; GED; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SMART; SM00302; GED; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00410; G_DYNAMIN_1; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
DR PROSITE; PS51388; GED; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW GTP-binding {ECO:0000256|RuleBase:RU003932};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU003932};
KW Reference proteome {ECO:0000313|Proteomes:UP000095285}.
FT DOMAIN 30..297
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT DOMAIN 519..624
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 654..746
FT /note="GED"
FT /evidence="ECO:0000259|PROSITE:PS51388"
FT REGION 756..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 844 AA; 95135 MW; F1C812FE159817ED CRC64;
MSWANTGMQA LIPIINRLQD AFAQLGTSLN FDLPQIAVVG GQSAGKSSVL ENFVGKDFLP
RGSGIVTRRP LILQLVHDQH VEYGEFLHKR GQKFTDFDMI RKEIEDETDR ITGQNKGISP
IPINLRIFSP NVLNLTLIDL PGLTKVPVGD QPPDIEHQIR EMLLTYISRE TCLVLAVTPA
NSDLATSDAL KLAREVDPQG LRTIGVLTKL DLMDEGTDAR DILENRLFPL RRGYIGVVNR
GQKDIVGKKD IRAALDAERK FFISHPAYRH LADRLGTPYL QRTLNQQLTN HIKDTLPALR
DSLQKKLYAL EKDVNEYKNF QPNDPSRKTK ALMQMVQTFT TDIERSIEGS SSKAVSTNEL
SGGARINRIF HERFPFEIVK MEIDEKEMRR EIQIAIRNIH GIRVGLFTPD MAFEAIVKKQ
IERLKEPSLK CVDLVVNELA SVVRQCAQCV ARYPRLRDEI ERIVTTNMRE KEQSAKYHIS
MLVDYELAYM NTNHEDFIGF SNAEAKASST SQKKNLGNQV IRKGWLSVHN ISFVRGSKDC
WFVLTSDSLS WYKDDEEKEK KYMLPLDGIK LRDLEAGFMS KQHKFALFYP DGKNIYKDYK
QLELSASNLD EVDAWKASFL RAGVYPEKEK PAEDGESVTA IEESSVDPQL ERQVETIRNL
VDSYMRIVTK TIRDLVPKAI MFLIVNKVSE FLRDGDLLAN LYQLGDTDSL MEESQLEAQK
REEMFRMYHA CKEALKIIGE VNMSTMSTDA PPAVASDWLR SNGPSPIPRP GVGGGLTAQR
PAPMPPRLTG NVPSTSSLAN RPLPGPPGGL PAPLLPIRVH NNSAVQNGVP PRIPDRPQIP
SRPY
//
