ID   A0A1I7VR63_LOALO        Unreviewed;       379 AA.
AC   A0A1I7VR63;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=VPS37 C-terminal domain-containing protein {ECO:0000313|WBParaSite:EN70_5373};
OS   Loa loa (Eye worm) (Filaria loa).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX   NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_5373};
RN   [1] {ECO:0000313|Proteomes:UP000095285}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA   Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA   Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Loa loa.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:EN70_5373}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular
CC       trafficking process. Required for the sorting of endocytic
CC       ubiquitinated cargos into multivesicular bodies. May be involved in
CC       cell growth and differentiation. {ECO:0000256|ARBA:ARBA00025010}.
CC   -!- SIMILARITY: Belongs to the VPS37 family.
CC       {ECO:0000256|ARBA:ARBA00007617}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A1I7VR63; -.
DR   STRING; 7209.A0A1I7VR63; -.
DR   WBParaSite; EN70_5373; EN70_5373; EN70_5373.
DR   eggNOG; KOG3270; Eukaryota.
DR   Proteomes; UP000095285; Unassembled WGS sequence.
DR   GO; GO:0000813; C:ESCRT I complex; IEA:UniProt.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR   GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR   GO; GO:0009056; P:catabolic process; IEA:UniProt.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.287.660; Helix hairpin bin; 1.
DR   InterPro; IPR037202; ESCRT_assembly_dom.
DR   InterPro; IPR029012; Helix_hairpin_bin_sf.
DR   InterPro; IPR009851; Mod_r.
DR   InterPro; IPR027486; Ribosomal_uS10_dom.
DR   InterPro; IPR036838; Ribosomal_uS10_dom_sf.
DR   PANTHER; PTHR13678:SF27; LD45836P; 1.
DR   PANTHER; PTHR13678; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37; 1.
DR   Pfam; PF07200; Mod_r; 1.
DR   Pfam; PF00338; Ribosomal_S10; 1.
DR   SMART; SM01403; Ribosomal_S10; 1.
DR   SUPFAM; SSF140111; Endosomal sorting complex assembly domain; 1.
DR   SUPFAM; SSF54999; Ribosomal protein S10; 1.
DR   PROSITE; PS51314; VPS37_C; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095285};
KW   Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274};
KW   Ribosomal protein {ECO:0000256|ARBA:ARBA00022980};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          97..186
FT                   /note="VPS37 C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51314"
FT   COILED          79..113
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   379 AA;  43838 MW;  F008291AD61B13EB CRC64;
     MVDVSYESLL DICVSAAMTS IRNMNYDQIG ELLNNDAEKK IDDIIDNISQ VRTLPTEREM
     GLVQNKSLAE WNLSQEPKIE EAKRRLRTTY EEAVKVKDEV MELKEKLNSL SEERSLDTST
     ALLQAAAQSV DDESEAIANR YLSGEIEVDQ FLKEFIEKKT LAHMRKIKAD KLSVILRQQQ
     YPQQPSSNFR TSPYLTKGAG LYPQPVSSPS FRQSFWAKVK KIDPWQLYEP MIKNTKIYPE
     YPTLNLQLDS MDFVPLEKFH SYAHKKARQF EFKVIDSYAI PPTKVILMPE KPDKGKQEKE
     IVLSTYHRFL RLSEVPCVRL SLYLHLIQAH APIGIAITIK KQEQADEDIR YIPDEILEAR
     KTELLSLDDP KTRKLLGWE
//