ID A0A1I7VRW2_LOALO Unreviewed; 1451 AA.
AC A0A1I7VRW2;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Multiple epidermal growth factor-like domains protein 6 {ECO:0000313|WBParaSite:EN70_5599};
OS Loa loa (Eye worm) (Filaria loa).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_5599};
RN [1] {ECO:0000313|Proteomes:UP000095285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Genome Sequencing Center for Infectious Disease;
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Loa loa.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:EN70_5599}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 7209.A0A1I7VRW2; -.
DR WBParaSite; EN70_5599; EN70_5599; EN70_5599.
DR eggNOG; KOG1218; Eukaryota.
DR Proteomes; UP000095285; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 7.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR042635; MEGF10/SREC1/2-like.
DR PANTHER; PTHR24043:SF8; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24043; SCAVENGER RECEPTOR CLASS F; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 4.
DR Pfam; PF00053; Laminin_EGF; 9.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 30.
DR SMART; SM00179; EGF_CA; 6.
DR SMART; SM00180; EGF_Lam; 24.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS00022; EGF_1; 17.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 11.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000095285};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 77..118
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 162..202
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 354..390
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 621..651
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 745..780
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 845..875
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 883..918
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 969..1004
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1135..1170
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1178..1213
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1307..1342
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 380..389
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 641..650
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 770..779
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 865..874
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 908..917
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 994..1003
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1160..1169
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1203..1212
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1332..1341
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1451 AA; 157801 MW; 2FD565F5763A3A73 CRC64;
MADVNRSVKK GMDDFIDASV AKGSNSLPTN GDVIVTIDPC AVNRGGCEQH CVNDNGRAVC
QCYHGFTIGP DQKSCIDIDE CATTKDSECE HECINVYGTY RCRCRPGYQL LSDGRQCKPI
IDPCQNRNGD CEQICESNED GSLKCSCRAG YQLIDDDRSC SDIDECMEDN GGCKQLCINL
PGSYHCSCRT GFLLIYDGKT CEDINECIAN NAGCEHHCIN EEGGYACTCE VGYNLASDNH
SCHGSVLFHS DLDINECLTN NGECSQLCKN EDGTYHCECF RGFSLANDAK TCIENAGRIA
SLTDHDIIEH ELQQEHFEVL TQEANIPHDL PKLSHFGTIR MLHSLPTACE YGRFGAECRY
RCADCKNGGK CRRNKSGCEC ASGYTGIVCE DRCPEGTWGL GCKKACECNG QICNHITGEC
DCPDGAECED SCPAGFYGPS CNLPCQMTCS SGRCDRKYGY CSCPAGYYGE KCDQICPRFN
YGRNCRHVCN CEIEYSEGCD PKTGKCICKS GFYGPFCKRR CPVGFYGQSC TKKCWCAENQ
ECDSISGDCI KKCRPGYTGD QCQIPCPAGM YGYNCTQKCA CEAGASQVCH HVTGTCTCRP
GYYGVLCEKM CPTGLYGPNC QHECSCKNNG TCNSKDGSCI CPPGYYGAAC SEVCPSHRFG
LNCMQRCDCH NGADCDPSNG SCKCLTGWSG QKCDIPCPEG YFGINCSERC NCDQGVQCDP
IDGECTCPTG HHGKNCELRC EEGYFGDRCK GICICRNNAT CDPTNGACNC KPGWRGQHCD
RPCPDGRYGD GCKKVCDCSS FDDTEMALFV LKCHPVTGEC LCKEGWTGSN CRTPCPSNSW
GIGCKEECQC MNGGICDRFT GNCDCPAGFM GPHCEEECPP DHYGPNCNSH CLCMHNGTCD
PKNGTCKCVI GWTGPACEFM CPFERYGINC EQVCNCMRGG RCNRTDGTCQ CLPGSIGERC
ERICPHGLFG ENCEELCLCE NGASCDPISG HCHCAPGWRG RKCNRPCLKG YYGQHCASAC
RCPNQKPCNH ITGRCHCPNG YTGHFCTELC PLGTFGENCA QQCECAPNAN CDPITGKCFC
KPGYAGVDCA QDKFHSITYD DININKSVMS SVYYSLNSHL STTYNSNLGC IQGRYGMNCD
GICQCVNGGT CDKATGQCIC PPGFVGTKCE VNCPSNRFGE NCERLCQCEN GGNCDRITGQ
CRCAAGFTGL QCQQVCSEGR FGPGCREKCR CANQAHCDPV TGACKCSLGY TGATCDQPCP
DGKYGPNCTL DCECHGNAKC DPVQGCCDCP SGRYGTRCQY TCPAGFYGWY CSQSCDCQNG
ATCNPSDGQC QCRSGYFGKQ CERSCTNNTY GPHCQLHCDC GEFQCDPETG KCDCPLGLHG
AKCKQACRPG RYGKNCEYRC ECYNGAICDR ITGQCTCAPG YLGATCQQEQ FDMESVAKRG
DLPEYDFRKK R
//
