ID   A0A1I7VSF0_LOALO        Unreviewed;       589 AA.
AC   A0A1I7VSF0;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Integrator complex subunit 11 {ECO:0000313|WBParaSite:EN70_5737};
OS   Loa loa (Eye worm) (Filaria loa).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX   NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_5737};
RN   [1] {ECO:0000313|Proteomes:UP000095285}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA   Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA   Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Loa loa.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:EN70_5737}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. RNA-
CC       metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
CC       {ECO:0000256|ARBA:ARBA00007093}.
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DR   AlphaFoldDB; A0A1I7VSF0; -.
DR   STRING; 7209.A0A1I7VSF0; -.
DR   WBParaSite; EN70_5737; EN70_5737; EN70_5737.
DR   eggNOG; KOG1136; Eukaryota.
DR   Proteomes; UP000095285; Unassembled WGS sequence.
DR   CDD; cd16291; INTS11-like_MBL-fold; 1.
DR   Gene3D; 3.40.50.10890; -; 1.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR022712; Beta_Casp.
DR   InterPro; IPR041897; INTS11-like_MBL-fold.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   InterPro; IPR011108; RMMBL.
DR   PANTHER; PTHR11203; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER; 1.
DR   PANTHER; PTHR11203:SF37; INTEGRATOR COMPLEX SUBUNIT 11; 1.
DR   Pfam; PF10996; Beta-Casp; 1.
DR   Pfam; PF16661; Lactamase_B_6; 1.
DR   Pfam; PF07521; RMMBL; 1.
DR   SMART; SM01027; Beta-Casp; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000095285}.
FT   DOMAIN          16..226
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|SMART:SM00849"
FT   DOMAIN          246..364
FT                   /note="Beta-Casp"
FT                   /evidence="ECO:0000259|SMART:SM01027"
SQ   SEQUENCE   589 AA;  66746 MW;  A84730F049C83AAA CRC64;
     MPEIKIVPLG AGRDVGRSCI LVSIGGKNVM LDCGMHMGYS DERRFPDFSF ISGGGSLTEF
     LDCVIITHFH LDHCGSLPHM SEVIGYDGPI YMTYPTKAIA PVLLEDYRKI QTEFKGDKNF
     FTSQMIKNCM KKVIAINIHE KIDIDNELSI RAFYAGHVLG AAMFQIMVGS ESVLYTGDFN
     TTPDRHLGAA RVEPGLKPDL LISESTYATT IRDSKRARER DFLKKVHDTV SNGGKVLIPV
     FALGRAQELC ILLESYWERM NLKYPIFFSQ GLAEKANQYY RLFISWTNEK IKRTFVERNM
     FDFKHIRPFE QSYIDSPGPM VLFSTPGMLH GGQSLRVFTK WCSDEKNLII MPGFCVANTV
     GAKVISGMKK IEIAGRMREI NLGVEYMSFS AHADAKGIMQ LIRDCQPKNV MFVHGEDAKM
     EFLKEKVEKE FNLKVFKPAN GETITIESPL NVSLNVPVQI LDRCISLDPT PSKRFCPFRA
     FLTMDKQTNQ LEVITPEAAA RQLGTSLHTI AFSETIEVDH INWNCFAAKL KVYDPNLQVK
     EDGIEMFNGE VTLASVMDNP KHVEITWDEI REDWSEEIIS ALRKEMLFL
//