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Database: UniProt
Entry: A0A1I7VT37_LOALO
LinkDB: A0A1I7VT37_LOALO
Original site: A0A1I7VT37_LOALO 
ID   A0A1I7VT37_LOALO        Unreviewed;      4961 AA.
AC   A0A1I7VT37;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   07-NOV-2018, entry version 11.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|WBParaSite:EN70_5995};
OS   Loa loa (Eye worm) (Filaria loa).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX   NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_5995};
RN   [1] {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_5995}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25217238; DOI=10.1186/1471-2164-15-788;
RA   Tallon L.J., Liu X., Bennuru S., Chibucos M.C., Godinez A., Ott S.,
RA   Zhao X., Sadzewicz L., Fraser C.M., Nutman T.B., Dunning Hotopp J.C.;
RT   "Single molecule sequencing and genome assembly of a clinical specimen
RT   of Loa loa, the causative agent of loiasis.";
RL   BMC Genomics 15:788-788(2014).
RN   [2] {ECO:0000313|WBParaSite:EN70_5995}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
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DR   WBParaSite; EN70_5995; EN70_5995; EN70_5995.
DR   Proteomes; UP000095285; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00472; MIR; 3.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS50919; MIR; 3.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000095285};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095285};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4517   4534       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4575   4597       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4713   4735       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4755   4780       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4840   4859       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      104    158       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      165    209       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      297    355       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      534    755       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      972   1166       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1409   1613       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4074   4109       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN     4112   4144       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    4087   4098       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND    4122   4133       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   COILED     2158   2178       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4961 AA;  563948 MW;  A7CE7B45899A9DCF CRC64;
     MTDKEGTGDG EQDDISFLRT GDIVAMTCMA SANREGVLGS ERVCLCTEGF GNRMCSLENV
     SDRDLPPDIS MCMLYIDNAL SVRALQEMMS NDKELRGAGS GGGHKTLLYG HAVQLKHVQS
     EMYLACLSSC SSNDKLAFDV GVQENNEGEA CWWTIHPASK QRSEGEKVRV GDDVILVSVA
     TERYLHMTHS KGFMVIASFH QTLWNITSVS SGSVRIRNMG ALFGNDVLRF FHGNDEVLTI
     PENWSEHPQH KYLGVMENVI QLYDKDKAEF DTTAFVMYQT KDLKKQLLEE KEEGMGVATI
     RYGETNAFIQ HIKTELWLSY QTSEITKKGL GKVEEKKAVA LKDGHMDDCF TFFMALEEES
     KSARVIRKCS SVLNRFLKGI EALQREGKQA QDWSRVDLSE VLKLMEDLID YFSQPNEDDF
     EASQNRLRAL RSRQDLFQEE GVLNMILDTI DKFSQMEAVS DFAGLLSEDT QLMWEEISTY
     LYLLVAAMIK GNHYNCAQFA SAQRLQWLFG RLSNPQSAEG ILDVLYCVLT ESPEALNMIN
     ENHIKSVISL LEKVGRDPKV LDVLSSLCEG NGMAVRSSQN TITQHLLPGK DLLLQTKMRD
     HVSSMTPNIL VGVVEGSSQF RRWYYEAEVE HIEQMTKTEP YLRIGWANSM GYKPFPGSGD
     GWGCIGIGDD YYSYGFDGRC IYCATKKHVI WTRTLQKGDI VGCLLDLNIP EISFTVNGQS
     TTGLFKNFNI DGFFFPVMSL SAKVSCRFMF GGTEGRLRFG PPPGFSALIE AAANKLEIGE
     CVSFGDIAKN IYTGPSILRQ NTEPFVPKLV DISTVVLPHF AMEIHEKVAE NLHELWAMRK
     IELGWSYGEV RDEKTRRHPC LTSFQQLPPN EKAYNINLAI DTMKTIEALR YHMVLDEPPV
     RLRAVRLSQN YQQSNGFKPQ PLDSHEIVLD DNIFPLIDAL AKNTHNVWAR EKIRRGWTFG
     LNEFVNMSQK RSPHLVPYEV VDQRIKEANR ESATEFIKTL QLFGIFLESP VLEHDEGAEK
     EWKATKAFSR TYRAEALYAV SSGKWYFEFE VLTSGFMKVG WMDVSAQSTA DIGMDDRSYG
     FDGYLARKWH QGAGTYGREW KIGDIVGAFL DLSDRTISFS LNGELLLDPS GSEMAFDNVL
     VTDGFVPAMT FSAGQKAKLN FGQDSNSLKY FTTCGLQEGY EPFCVNMYRQ MPMWYAKRLP
     QFEDIGLNST IEVSRIPATG NSPPCLKITQ KEIDTGDMTV QEKAKMEYIR LSLPVKCNDK
     LQPTKDKESI MRSLHEIEKQ LAEEAQPVAT IRHPAIPKEF GDDTKLNKAK EDENSPRSKP
     ISFDGEHHLA ETSTIRMSGS MLELSSTEEH REGKHKRGGL MARFHQRKKE GVSSESKRTT
     GVLPDGHIAN ADAISAESVP PSMPKDDQDM PRSGPGRSRR LIGSDKLKKK NERLLEHRRP
     SLAALEQSVT VEGNVPSYDV QPMIELSDKI DEFYYAIRIF PGQDPANVWV GWVTPKYHFY
     AERFVIGEAV RRCKYQEINK NVNEGESLEY RNCYVMNAAE LLQSVPDSGN TKVSGLLIGC
     IIDTSIGELS FLASKQDTGF RFKLEPGAIL YPAAFVAPTS AEVLQFELGR IKYTFPLSSA
     MFKSSHKSLL PFCPPRLTVQ KLNPVHWARV PNECLRTTAL KLSDFRGWSV LCDDPVRIMS
     IYVPEKDTSY DILEMIEHND FLIFHRQTLN LYCKLAAHGN QKVAHILCSH VDEDQIMYAV
     KSHYLSGPLR QGFHDFLIAV HLRTYVDARQ STAREYVIPL KQNREIKNIF HPENEDRFPQ
     ILGPTISIRP TIVCSEVHND FGKDAESKLL PPALNFAALK AHVMSALSSA TEHAVISCRD
     LIGGNCLNHF EPLFKLFNSL LVIGMFDDDD LKDVMKLIHP IVFDENYMPG SKQKGLTEIE
     LAEGVKIQLT IILESICDIQ LRHRVESLVS FAAGFVSDLQ QDQFSRYMSI KQTDMSPAEA
     AKRTKEFRCP PREQMFRLMK CKAVPDDNVG IMLDDETEYD QCPMDEALQQ QLREFCSLLV
     NKAGCAKNEE SNELSELIVL EETNSWVDQL AQLVIRVPPP LSGEDKNINH NGTENFRHMI
     CTMLKSWATS SVIESNELIR KMFSLLLRQY TGVAEMMKAL SQTYVLHERN IEDVQDFIEN
     LVQVRELLNV QFENAEEAVL KRGLWKLMNN RIFFQHPDLM RLLTVHENVM CIMMNVLTAQ
     QGAANHGEPA EQVENIEEIA NAQESKDASE MVVACSRFLC YFCRTSRQNQ KAMFEHLSFL
     LDNATMLLAR PSLRGSVPLD IAYSSFMDNN ELALALKEDE LDKVTVYLSR CGLQPNLELV
     AKGYPDIGWD PVEGERYIDF LRFCVWINGE SVEENANLVI RLLIRRPECL GVALKGEGQG
     LFSAFKEAIA LSEDIRALEE NENHTVIHSA LLREQPHYPN KETEGEDYVD LGAATLDFYS
     SLVDLLAKCA PDKINIQAGK GDCMRARAIL RSLISLDDLG QILALRFTIP NLIASVATDD
     AGPLPGLLPN HKQSVLLFLD RVYGIDSQEM LFHFLEKSFL PDLRAATMMD SPCSVESDTA
     LALNRYLCNA VLPLLTSHSY YFANAEHHAA LLDTTLHTVY SMNRLRSLTK NQRDAVSDFL
     VAITHELPPS MMVKLMRKVI NDIQEMDENL LVPLRILTLH YERCTKYYGS GNLYGVASET
     EKRLSMLLFY AIFDSLGSKQ YDPELFGKAL PCLTAIGSSI SPDYTLTTTG DDMDKIQKTK
     DRGIWNPDPV DVSGIHFHDD LKSVIAKFAE HFHDSWASRK EKNFYQERCA ECLRALLVWN
     YSIELTDHDA ADKAVQNNAS LSSTSIENFN PKPLDLSNMT LEKDMMGIAE KMAEESHKIW
     AKKVLVDLSR GGTMPPQLVP WDLLTDFERR KDRFRAAEIL KFLQCHGYRV WSLNKAEPSA
     ERVKIDSERS SVEKRFAYNL LKKLIQYLEQ ASLKMKTIKP SQELTRQNSF RKEGQDVKFF
     EKVVLPLMHA YFNAHKNYFL ASSSIVQTGM ASDKEKEMVA NLFCRLASLF RFKNHAFGNV
     AKITVRCLQG LTQALDLRTL VKINSDIVRT GLLTFFNNCA DDLFSAVEEL RNNGQYSLLR
     GQNLKSWVSL EFANQMIIPV LTTMFVHLGI NHFGSDLLLD EIQAACYKIL DSAYLLNSLA
     ATTSQRKSIA YEMDKHRPAL GQCLAAFAGC FPVAFLEDKF NKNNKYSLLA KSQDQSVQVQ
     EMLQNLLAHI PQLDKLLTEV EQVGQTDVMY RDQPAIYDVD LPLICSYLTY WWQLGPDSSN
     RSTVLDFSVP VTDVGSEYIN RIFRVLLQMI HNHIGVENAS WLCRINFFSV QITPYVSCDM
     VKDYMLPVAE RLRRLAEKAY REEEHMRTHP DDADEGTVAE DNAHLVRDVY AYFPVLMKYT
     DLHRAQWLKS PSWETDGIYE NVAVIFKIWS LSQHFKREEL NFMAQYEDES VAGGTGEMKT
     GKAAIAERKK KRREGQMRKD KHAGSIVIAC LKRLLPVGLN VFGGRELDIV QQAKEKFLAK
     EPEDKIRELV RSLLDVPAKT DPTDKNAWQL NLYRKIGKSQ MRNKDVMTLD GIVDKITSMG
     QVVAILHIAT SKFKKESRWR RVLTLQRKRM AISLITASHL YRVEIHRAIN FFLPAFNKLW
     LEDEDVGQDA LIKELILEDE KQEQAHSKPG DEEVLSDEKD EKSQAPPDPL RQLIQCFQRA
     ATSEQSQTIS IANDSLFVNF AKVMSKSVHI EDEDEGDDEG ELDQAQKEEI SQALRAEQAV
     LADRGAAIMC LMYLSASNGE PSDMVAEALQ LGIHLLNGGN SKIQEMLIGY LQLKKDVRFF
     TSLAGLMNKC SVLNLEMYER QIKAEGLGMG AELAAAANQN LNDSEFTCSL FRFLQLTCEG
     HNLEFQNYLR AQPGHTTSVN LINCTVDYLL RLQESVMDFY WHYSSKDVID ESGKEYFLRA
     IHVCSQVFNT LTESIQGPCT GNQMTLANSR LWDAINGFFF LFAHMMEKLY KNSTQLELLR
     EFLNLQKDMI VLMLSMLEGN VLNGSIGKQM VDALVESEQN VEMILKFSDM FLKLKDLTTS
     QAFQDFDTNR DGWISPKEFQ RAMESQKMYS VEEITYLMMC TDVNNDGKVD YMEFTERFHN
     PARDIGFNVA VLLTNLKEHI TSDPRLEKII KQASSLLEYF DPYLGRIEIM GSSKKVEKIY
     FEIQESWLEQ WSKQQIRDSK NSFLFNVLQD DGGDQGKLEA FINFCEDTIF EMQYAAEISA
     GDIADSKIER AKKQRDYFLQ QTSAGAQISA TFKTGFSYGI NAANALKPAN VKKIVSTANA
     NFRSMTWAQL TLAIITLSAK VSVKVAMFIY LVSCTLFRFG YYLMTPDRDE LEVEQAALPM
     PESTGMPHIS PVWPSLQQYH RSCNYDVFGV RLSPTHAQTP TTFQGQSKAE ATDAPTSVQQ
     SETVLKPSLA AQQGPSLYET QSVSSIAAHY NQVVSPTISE CGVTDYYEPK IAEQIPPRSR
     GSLLNMLARN FKTIEKTTLY LAFFINVILL FHRIRISDSV TSVGDTDEDM ESVYISGVVL
     PYTSCEVTGW MLAQLLYWIS VLHAVASFAL LVSFYQLKIP LITFKREKEV ARRLMFDGCW
     LTEDDDEERS LTNTVFWYID RIVISSKSFP MKYWDKFVRR KTRQKFRDQI DEETLITVLG
     EDKPATDTAF DYRYACWLWL GVILTNGQFL YRVHYLLCSA LGVFVSPFFY AFHLIDVVLS
     FPMLKAILQS VTHNLQQLIL TIMMTLVVVY LYTVLAFNFF RKFYVQEGEG DEPPDRKCHN
     MLTCFIYHFY AGVRAGGGIG DELESPYGDD LEYWRMLYDI SFFFFVIIIL LAIMQGLIID
     AFGELRDQQE SATEKLESSC FICDIGKETF DRLPRGFEIH TSKEHNFANY LFFLQHLVNK
     DETEYTGQET YVREKYDNRD WEFFPVGECF MKQYEDQLLQ S
//
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