ID   A0A1I7VU49_LOALO        Unreviewed;      1064 AA.
AC   A0A1I7VU49;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=UCH_1 domain-containing protein {ECO:0000313|WBParaSite:EN70_6318};
OS   Loa loa (Eye worm) (Filaria loa).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX   NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_6318};
RN   [1] {ECO:0000313|Proteomes:UP000095285}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA   Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA   Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Loa loa.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:EN70_6318}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
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DR   AlphaFoldDB; A0A1I7VU49; -.
DR   STRING; 7209.A0A1I7VU49; -.
DR   WBParaSite; EN70_6318; EN70_6318; EN70_6318.
DR   eggNOG; KOG1275; Eukaryota.
DR   Proteomes; UP000095285; Unassembled WGS sequence.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR048841; PAN2_N.
DR   InterPro; IPR028881; PAN2_UCH_dom.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR15728; DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2; 1.
DR   PANTHER; PTHR15728:SF0; PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2; 1.
DR   Pfam; PF20770; PAN2_N; 1.
DR   Pfam; PF13423; UCH_1; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
PE   4: Predicted;
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022839};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095285}.
FT   DOMAIN          51..332
FT                   /note="PAN2-PAN3 deadenylation complex catalytic subunit
FT                   PAN2 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF20770"
FT   DOMAIN          486..836
FT                   /note="PAN2 UCH"
FT                   /evidence="ECO:0000259|Pfam:PF13423"
SQ   SEQUENCE   1064 AA;  119824 MW;  63FC11B63AA3B9D4 CRC64;
     MYGSSPGHSE DVLISADGLT PMSNEARIPE GGFALLSTTP QNAALAHFIT ALTFDSYQEL
     LWTGNNMGRV VSFYGAQLDK YTAFLSASNS SIRSLLASET VIFSLTSKRL RANRRQGISL
     FTHTSDHMTD LTCMHRLSDV PHKLLLGGNQ QQIIQFDVET QKEIRIVSVK QKNCLALRSN
     QKFLFSSDSE GNVTLRHLTT VDAIHALQAH QGSVADFDVC GNKLITCGYS PRLGKMAGDR
     FIMIYDLRTL RSLPPVPLPI APSYCRFLPS YSDGRIMVCS QSGELIIMDL NEQSGQMPIQ
     LDTNGFAITS LDVSTSKQCI AFGDQTGLIH LFSDRMEPIF NENSWGTDFP DPIAFHPPVN
     IDDPEPSYGV FPLPFPMDDH YASDWPEQLC IRRFRQPDPI SEKVIDSMRM VQFVGYAHNP
     RAGTPLRGFN VCPYTSSAHD KRFSNTMKSD ELFHIPKFYL RSEGRLTSKA DEIDSKRYNR
     IEFNVLENSV ETSPACMLLL AMYHLMNVRT VFLSHFCYLE GCISCEMNLL FRLLTDRPVS
     SVLSAKNFMK TFRSIDDGKK WADAVANASL AQAVHLFMQA FSKVLDRELS ETTAGVALRK
     ELEISFTLNN HCIRCSEHYQ SALSQLYMSL AYPTNNEKIG FCTLLEKTLN CPEQNEAICQ
     KCGKLARFAS TRRVRSLPNI LALDMTASTE TEQAFWISHI QAFESRAAIT SNSITEQKVK
     LCSQSETMTS MTEGTTSYSE CPHYLPNSVH IKITDGICTV SENKMESSTS FHLAAGIFII
     NENEEEGTNE HLVTAIRSKR VCSSFVFNSL SSVILCWLNI FTCKDSCWIL FNDWSVTRIS
     EDEALRLHAC WKLPAVLYYV QDKENVAKEA AKDENRAIIP RSVFWNDLDS NKIKIPERGS
     RVAIYAKYTI NETGDKSVSE VSAVDEDGNC FISSIIKEPG AKRDMDNSQT LKRVSLKLLY
     LIQEKITIIG YQIEHLFEML NIHVSEEQVK DIVLLYRSLF KRSLSLNALA QHFFGESIEE
     DETDPIDLAR LSLRLHTKFD ELKEADETDI NTTSLTQSVE TNIS
//