ID   A0A1I7VVJ8_LOALO        Unreviewed;       788 AA.
AC   A0A1I7VVJ8; A0A1S0UND4;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   RecName: Full=Nuclear cap-binding protein subunit 1 {ECO:0000256|ARBA:ARBA00019879};
DE   AltName: Full=80 kDa nuclear cap-binding protein {ECO:0000256|ARBA:ARBA00030965};
GN   ORFNames=LOAG_16677 {ECO:0000313|EMBL:EJD76387.1,
GN   ECO:0000313|WBParaSite:EN70_6736};
OS   Loa loa (Eye worm) (Filaria loa).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX   NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_6736};
RN   [1] {ECO:0000313|EMBL:EJD76387.1, ECO:0000313|Proteomes:UP000095285}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA   Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA   Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Loa loa.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:EN70_6736}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the NCBP1 family.
CC       {ECO:0000256|ARBA:ARBA00007413}.
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DR   EMBL; JH712077; EJD76387.1; -; Genomic_DNA.
DR   STRING; 7209.A0A1I7VVJ8; -.
DR   EnsemblMetazoa; EJD76387.1; EJD76387.1; LOAG_16677.
DR   WBParaSite; EN70_6736; EN70_6736; EN70_6736.
DR   eggNOG; KOG1104; Eukaryota.
DR   OMA; TMQLECI; -.
DR   OrthoDB; 5477544at2759; -.
DR   Proteomes; UP000095285; Unassembled WGS sequence.
DR   GO; GO:0005846; C:nuclear cap binding complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000339; F:RNA cap binding; IEA:InterPro.
DR   GO; GO:0006370; P:7-methylguanosine mRNA capping; IEA:UniProtKB-KW.
DR   GO; GO:0006406; P:mRNA export from nucleus; IEA:InterPro.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.180; -; 3.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR027159; CBP80.
DR   InterPro; IPR015172; MIF4G-like_typ-1.
DR   InterPro; IPR015174; MIF4G-like_typ-2.
DR   InterPro; IPR003890; MIF4G-like_typ-3.
DR   PANTHER; PTHR12412; CAP BINDING PROTEIN; 1.
DR   PANTHER; PTHR12412:SF2; NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1; 1.
DR   Pfam; PF02854; MIF4G; 1.
DR   Pfam; PF09088; MIF4G_like; 1.
DR   Pfam; PF09090; MIF4G_like_2; 1.
DR   SMART; SM00543; MIF4G; 1.
DR   SUPFAM; SSF48371; ARM repeat; 3.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   mRNA capping {ECO:0000256|ARBA:ARBA00023042};
KW   mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW   mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095285}.
FT   DOMAIN          41..248
FT                   /note="MIF4G"
FT                   /evidence="ECO:0000259|SMART:SM00543"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          644..709
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   788 AA;  92790 MW;  D68A3869724708C5 CRC64;
     MNHLPHIDHD RRRRTNDEGN DWPYKRRRSV PERTGSEVRL ELLISRIGEK SNSSMESNLE
     GLAQSLGTYL ITDVDHIIDI IIDCVCYLRE EITAYSTLAG LLNSKKEKFG FELLNQLLEV
     LREKLVSSDF IHALHIVTFL ADLVNCHVVS SSSLVEFYES FMEAAYEESI PQVRSDWFVY
     AVLHSLPWAG PELNDREKEP LDNLLEGIDK YMLERNTSHA KLLQVWSATE HEQEEYLDSL
     WIQISKLRDD GWAERHILRY YVAFDGSLAG AVTHNLPLFV PPPHTSVMVY PLPTVVFRFF
     DYADCPDGGA VLPGAHSIER FLVEEELCLI IGNNCYSRKE CAAQLISYRK KTMVPINYMI
     LEVIFSQLFR LPHPPLRPLF YGSVMIELCK TRDMPQVIAQ AAELFYQRID TMQLECIDRL
     IDWFSYHMSN FEYRWSWVDW DDCLNLNDYA PRRYFVKEVI EKCMRFSYYE RICDCLPSSF
     EEITPEKPFI SFLLNREEKE MVAEIEKAFR NKAQPKEVTE MLRGFDQKSN SSATLSTFFA
     VMLNAAQKSF SHNFAALARY HETLKELSGV DDESSTALLQ TLYDVWKHNR QMMVVLITKM
     LRMTLLNANA VVSWLLSSCA GQELHRFWLW EALFMVVKHS CEHMNRCKIK LQQMQEKRAR
     MERNDRNAYQ RFCYNEEDDG LGIILDDDIE MKKKELKEIQ EMLKNLFLNV LHKLVVFLSE
     HVVKYETTGR NYDTYWYRYM MGRYKEILLR YWHELFEIKQ YIDKELFVTA GIDPKILEIY
     HQFIALRA
//