ID   A0A1I7VVS2_LOALO        Unreviewed;       863 AA.
AC   A0A1I7VVS2;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=CNH domain-containing protein {ECO:0000313|WBParaSite:EN70_6836};
OS   Loa loa (Eye worm) (Filaria loa).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX   NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_6836};
RN   [1] {ECO:0000313|Proteomes:UP000095285}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA   Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA   Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Loa loa.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:EN70_6836}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
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DR   AlphaFoldDB; A0A1I7VVS2; -.
DR   STRING; 7209.A0A1I7VVS2; -.
DR   WBParaSite; EN70_6836; EN70_6836; EN70_6836.
DR   eggNOG; KOG2063; Eukaryota.
DR   Proteomes; UP000095285; Unassembled WGS sequence.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR001180; CNH_dom.
DR   InterPro; IPR032914; Vam6/VPS39/TRAP1.
DR   InterPro; IPR019453; VPS39/TGF_beta_rcpt-assoc_2.
DR   PANTHER; PTHR12894; CNH DOMAIN CONTAINING; 1.
DR   PANTHER; PTHR12894:SF27; TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1; 1.
DR   Pfam; PF00780; CNH; 1.
DR   Pfam; PF10367; Vps39_2; 1.
DR   PROSITE; PS50219; CNH; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000095285}.
FT   DOMAIN          21..282
FT                   /note="CNH"
FT                   /evidence="ECO:0000259|PROSITE:PS50219"
SQ   SEQUENCE   863 AA;  97396 MW;  1BF7E5593FDF7BAE CRC64;
     MVDEYYRLIH VFETVSVFAP SEKVTCVDGT SRALFVGTSQ GRILLVNLST KNVINALQLS
     TNAPIARIVA ATALDYLIVL SASTIFNIEI KTLKPISSSA ASNIAHLALN KDPVVADPFA
     LQFALVTNNR YILVCESKAD NLVIQQEIRT EDNVVALSYN KYGICYALPN AYFVYNILEN
     KTLSLFPYDS QAILPIIINI DSEEFLVNGM QGLGVFATSE GVSSRPPLFW GLTSIVSFAY
     RSPHVFVLTA SSITVYSSEQ SVVLQRWPFT TGTLLECIDG QLYVCSSENI SHLEEISWLD
     RAEALADSGE LDEALRFAEN AVSNGQYDEA EILKFNELKQ KVALMLFKRE EFEKFYGLAV
     LSELDPRAVL ISFEFLLPFP SGFRSELSKE ITESSKEASD DCVMEGSVQL ITFLEHYLRT
     TRKFHWTAGF RRDIDALLLR LISLRQDALD AEDMSLNLHC TFDDCNEWMR KHKHRKFLIT
     IAFCLLDFDN ALAISQELYN ENLWDDGIAK LCLQFFPRFN SERTILGWVE FLLEVRQDDV
     IDGLRRCPVK LDHRKIVRIL QRKRNTLIKY LEGITSLQNI EFHSMLFSMY VDEINALLGE
     GGESEKSCRR KLRTFLLQPN KLNLLDTCAV LKSYPHFAVE LTLLEGVKDK GSIECLEKLL
     NDHKDYDAAE LFCIYTDTSE HVLRLTLLKF YLRNVASQPE FGSRITNLLN TPSFTSNGTE
     IMQNIPKEWS LSSILCFAEG TVLSTKDRSH CQQLKKKALK ALSKEALKAA QLHIQIDEKT
     TCTACGAPIS NEDAACYPNS SQSSNCANRT ESDELPRRAL DDCVGGVYQN VMDILDCGQL
     HDGHVQYHCC SLLSETLSTR KDF
//