ID   A0A1I7VVT4_LOALO        Unreviewed;      1474 AA.
AC   A0A1I7VVT4;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Integrase catalytic domain-containing protein {ECO:0000313|WBParaSite:EN70_683};
OS   Loa loa (Eye worm) (Filaria loa).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX   NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_683};
RN   [1] {ECO:0000313|Proteomes:UP000095285}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA   Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA   Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Loa loa.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:EN70_683}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
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DR   STRING; 7209.A0A1I7VVT4; -.
DR   WBParaSite; EN70_683; EN70_683; EN70_683.
DR   Proteomes; UP000095285; Unassembled WGS sequence.
DR   GO; GO:0042575; C:DNA polymerase complex; IEA:UniProt.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   Gene3D; 1.10.340.70; -; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 2.40.70.10; Acid Proteases; 1.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 2.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR040676; DUF5641.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR041588; Integrase_H2C2.
DR   InterPro; IPR008737; Peptidase_asp_put.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   InterPro; IPR008042; Retrotrans_Pao.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR22955; RETROTRANSPOSON; 1.
DR   PANTHER; PTHR22955:SF69; RNA-DIRECTED DNA POLYMERASE; 1.
DR   Pfam; PF05585; DUF1758; 1.
DR   Pfam; PF18701; DUF5641; 1.
DR   Pfam; PF17921; Integrase_H2C2; 1.
DR   Pfam; PF05380; Peptidase_A17; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095285}.
FT   DOMAIN          1080..1265
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50994"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          373..403
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1474 AA;  171759 MW;  FB97DA7402234A91 CRC64;
     MKQSKQTTSA ERNQLDQESP NWVTNKKRRP CIFCNNNHWD SNCHIYPTVE QRIDRLKEIK
     LCPNCFKLGH SEFDCKKRVS CFYCKKSHNS SLCTDKTNQF KQPKDSRVNK GKIVVKNANI
     SVNSTTKGEE KRVLLLCKEI TVFNPDKPEQ QVQALVLFDV GADATFISQK LAHRLNLRET
     DEEKYTISSF GNRNPKVCYV TQTQIGVKMK GSNHMTVQAN VMDYLTSELQ VVEVPDKYEI
     SNLRSYQKQP DIIIGADYFF DFIHMNNAQQ LKTGFTLLNS KVGPIIAGSG YINELCRRHI
     FATKIFQENR TPDIDQFWKL DCIGIQDRPD TQDDEQALEQ FKKSVTRQKG RYEVRWPWKP
     CKDKLSDNYG LCVNRLRMLI ARLQSHKEEL QEYDKIMREQ LRAGIIEEVQ PHMNQDGIIH
     YLPHHDVRNP GKTTTKLRIV YDASAHIKGM KSLNEVLYRG PINLPDLAGV LLRFRMMKGV
     ITADIEKAFL QIELHPSERN CTRFLWLKEV KERVSNENIK CYRFRRIPFG IISSPFLLSA
     TLNYHLENHD SELALEIKKN LYVDNVIVSL NGTRDALEKY VEMKSIFNEA SMNLREFLSN
     DEEFYAGLPH EDRAMRKNTK ILGIPWNPCQ DIIQAKLNPW TEQELTKRTI LQFVASQYDP
     LGFLVPIMVK FKIFLQHLWK ENKSWDQILD EQDHKQWKSL IAKWVTVVKD LPRFVTTFTD
     LIGIHVFTDA SSLAYSAAVY LVSQEMHGTK SSLIFSKSRI APIKGMTIPR LELMAILIGT
     RAAQFVMTQL DLTNIKVILW SDSKCALHWI KNHSNLLPRF VQNRVEEIRR TKCTFRYIPS
     EENPVDVATR GLNPKQLRGF MPWWHGPSWL VQGETSWPQW EYDFDNNDEP KEITVTEVSR
     MRKDHNLQFI DAGRFSKWLR LLRTTAWILK FIRLTTKNGL PWLQSASIEK DRFTAEDYKL
     SEWLLIRQAQ SEGVNDDEIN KWNLFYTEDD KLWRSASRLE NSELPETSKY PIYLPRHNPI
     TELIILQQHE NLCHAGITHT LSELRSRFWI PKGRTEVKRM INKCRICKRW NSRSFKLPPM
     ASLPETRVNR SRAFAYVGLD YFGPLSIKGN VPTKRWIILF TCFTTRAMHL ELAEDQSAET
     FLHAIRRFVA RQGYPGLILS DNATQFQAFK TIITQVAVSN FLAKEGMTWK NIVPKAPWQG
     GIYERLIGLT KNALKRAIGR KYLTERELVT LIAEVEGILN TRPLTYANFD DCVIIRPIDF
     ILPNASLHLP MIKNDDTQEE FIPHRLDTRE KLIKYWRNTL KTLDNFWEIW RTEYLTSLRE
     RTQREITSPK GAQKRTPRKG EIVLLNESGI PRGMWKLLRI KDVKIDKDGQ VRNVQVETPT
     GKLLNRPINV LYPLEVNNDD HLELNNKESA KVVEIEPDTV EHQEPIAMRT RSSTNQPNKL
     YFITNPTYSQ YQPSLVGSVV KTKPQIYSHC KLIL
//