ID A0A1I7VWI2_LOALO Unreviewed; 185 AA.
AC A0A1I7VWI2; A0A1S0TUS1;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=RING-type domain-containing protein {ECO:0000313|WBParaSite:EN70_7049};
GN ORFNames=LOAG_08164 {ECO:0000313|EMBL:EFO20327.1,
GN ECO:0000313|WBParaSite:EN70_7049};
OS Loa loa (Eye worm) (Filaria loa).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_7049};
RN [1] {ECO:0000313|EMBL:EFO20327.1, ECO:0000313|Proteomes:UP000095285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Genome Sequencing Center for Infectious Disease;
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Loa loa.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:EN70_7049}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JH712122; EFO20327.1; -; Genomic_DNA.
DR RefSeq; XP_003143744.1; XM_003143696.1.
DR AlphaFoldDB; A0A1I7VWI2; -.
DR STRING; 7209.A0A1I7VWI2; -.
DR EnsemblMetazoa; EFO20327.1; EFO20327.1; LOAG_08164.
DR GeneID; 9945587; -.
DR KEGG; loa:LOAG_08164; -.
DR WBParaSite; EN70_7049; EN70_7049; EN70_7049.
DR CTD; 9945587; -.
DR eggNOG; ENOG502SC5Q; Eukaryota.
DR InParanoid; A0A1I7VWI2; -.
DR OMA; EYYNYVA; -.
DR OrthoDB; 2879110at2759; -.
DR Proteomes; UP000095285; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR47156; PROTEIN CBG20824; 1.
DR PANTHER; PTHR47156:SF10; RING-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000095285};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 162..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 43..89
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 185 AA; 21486 MW; 33816D015EA64A78 CRC64;
MKRFFACLRL AIAQLDQDYS ESRRTAKIDG AERITVDSSA LHCPVCFCIF ASVPFILKCG
HSFCQNCIKN IVENSYSERD AVFECPMCRQ VISSEIRFTK NFLADALLQS VCEIAQDENE
SSVDPNLRIS FQLISRKFLE EQQKNNILRK KYEEERVRSR RYLILLVMES ALLIGFVFLY
KLLFP
//
