ID   A0A1I7VX50_LOALO        Unreviewed;       860 AA.
AC   A0A1I7VX50;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=Importin N-terminal domain-containing protein {ECO:0000313|WBParaSite:EN70_7248};
OS   Loa loa (Eye worm) (Filaria loa).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX   NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_7248};
RN   [1] {ECO:0000313|Proteomes:UP000095285}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA   Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA   Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Loa loa.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:EN70_7248}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the importin beta family. Importin beta-2
CC       subfamily. {ECO:0000256|ARBA:ARBA00038423}.
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DR   AlphaFoldDB; A0A1I7VX50; -.
DR   STRING; 7209.A0A1I7VX50; -.
DR   WBParaSite; EN70_7248; EN70_7248; EN70_7248.
DR   eggNOG; KOG2023; Eukaryota.
DR   Proteomes; UP000095285; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR040122; Importin_beta.
DR   PANTHER; PTHR10527:SF3; FI21453P1-RELATED; 1.
DR   PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR   Pfam; PF13513; HEAT_EZ; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000095285}.
FT   DOMAIN          36..104
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50166"
FT   REGION          327..374
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        327..343
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   860 AA;  95925 MW;  E894DCDD1829367F CRC64;
     MTGEAEDWRP IPEELQQVVQ LLQHSQSPDT QTQRNVQERL DQLNLHPEFC CYLVFILSEL
     KDEQVANRSL AGLILKNSIR MLWGRLPEPI RHYVKNRTLL AISDCHPLIR ATVGIIITTI
     VVHEGIVQWP ALLPTLCNML DGSDENLQEG AMGAIQKICE DSADMLAPQE HLSTLIPKLL
     CFFNSPAPKL RALALNSVNC ILLVQTEPLN NIMDIFLQHL FALANDIDTE VQKQLCRSLT
     LLLDSHLDKL ASQLGNIVEF MLLRTQDPNE ATALEACEFW LALAENPQIC KEALLPHLPK
     LIPVLVRCMR YSDVDVAVLK GDIDEEDGAI PDRQQDIKPR FHRAKTQMQT QKKSDTAVEE
     SMDDDDDGDD DSSTEWNLRK CSAASLDVLS SIFNDDFLPT LLPILKETLF HNNWLIKESG
     ILALGAVAEG CMSGITPHLP ELVPFLITSL QDRKLLARIL DGSKRVQEAA CSAFATLEEE
     ANLELVPYLP EILATLVEAF NRYQAKNLLI LYDAVGTLAD SVGPNLNEPQ YVETIMGPLM
     AKWAALGDDD KELFPLLECL SSVATALHEA FLPYCEPVFQ RCTALIGRCL QQSQLAMERP
     SEYDMPDKDF LIVALDLLSG LAEGLAEHID SLVGPSQIIA LVYQCSMDSS AEVRQSSFAL
     LGDLSKACYH YLQPHINIFL PILTQNLDPD SISVCNNSIW AIGEIAMKMG DGMRPHVLGL
     LPALIIVMNR EKGPKTLLEN TAITLGRLGI SCASEVAPFL PQFIRPWCLA LRNIRDNEEK
     ESAFRGLCNM INLNPAGVLA EFIFLCDAIA SWNNPQPELK MMFSRILHGF RQQVGDLNWT
     AFTSQFPAPL KQRLANQYDV
//