ID   A0A1I7VXN1_LOALO        Unreviewed;       686 AA.
AC   A0A1I7VXN1;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Tr-type G domain-containing protein {ECO:0000313|WBParaSite:EN70_7410};
OS   Loa loa (Eye worm) (Filaria loa).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX   NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_7410};
RN   [1] {ECO:0000313|Proteomes:UP000095285}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA   Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA   Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Loa loa.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:EN70_7410}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC       {ECO:0000256|ARBA:ARBA00007733}.
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DR   AlphaFoldDB; A0A1I7VXN1; -.
DR   STRING; 7209.A0A1I7VXN1; -.
DR   WBParaSite; EN70_7410; EN70_7410; EN70_7410.
DR   eggNOG; KOG1145; Eukaryota.
DR   Proteomes; UP000095285; Unassembled WGS sequence.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   CDD; cd01887; IF2_eIF5B; 1.
DR   CDD; cd03702; IF2_mtIF2_II; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.40.30.10; Translation factors; 2.
DR   Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR   InterPro; IPR044145; IF2_II.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR   InterPro; IPR015760; TIF_IF2.
DR   InterPro; IPR023115; TIF_IF2_dom3.
DR   InterPro; IPR036925; TIF_IF2_dom3_sf.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR43381:SF20; TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   Pfam; PF11987; IF-2; 1.
DR   SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50447; Translation proteins; 2.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095285}.
FT   DOMAIN          140..309
FT                   /note="Tr-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51722"
FT   COILED          415..446
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   686 AA;  76791 MW;  FF845E4F8A1E8D25 CRC64;
     MRQLVHLYTA RWLLGGSIVR FLRLSSKCYA KQKRRKFIDP VVVGKTPSKK KIAEIYDDMK
     VGELAKVLGS SEEEILQVLK NLHKLPRSNS EMLDMSSITT VVGAFGLKPK LIPRPRNAIN
     DDFELDAFPQ PPPPEDELKK RAPIITIMGH VDHGKTTLLD CLRHSQIVES EYGGITQHIG
     AFTLKDKDCE ITFLDTPGHA AFAKMRERGA HSTDIVVLVV AADDGVNEQT VQSINYAKQA
     DVPIVVAINK IDKANANPIQ AKHSLMKHGV LVDDLGGDVL CVEISALQGK NVDELKEAIL
     LQAEDMNLRS TWNGLVEGIV IESKIQCGIG KVCTMIVQRG VLVKGAALVA GTSWARVRAM
     HDEFGRELAK AVPSTPVVVA GWRENLPTPG ERVLQLENER RAQEVTRYRM KKEINKKVEE
     DWKTAEQRIE EERKEYLENR RKLLDAGLRV GSTLRLIVHK EQKYQKDVGN QKPCVRLMLN
     TDVDGTLEAI LNVFDTYKSE EVELDLVRFD VGPPSESDVK LAKDLGVLLY CFNVQVAPGL
     KRIAEQLGVE IVCFNVIYRL VEDLKIRLSN CLPEEVTFEQ VGEGHVIKSF SVIVERKRQS
     IAGILVDWGS INKSDSLRVL RGATVIFEGS IRSMRIGTQA VSSASKNEEV GVAVWNEKIV
     FKEDDIIETY REMKVKKQIS WNPPGF
//