ID   A0A1I7VXY2_LOALO        Unreviewed;       248 AA.
AC   A0A1I7VXY2;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=Frizzled domain-containing protein {ECO:0000313|WBParaSite:EN70_7495};
OS   Loa loa (Eye worm) (Filaria loa).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX   NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_7495};
RN   [1] {ECO:0000313|Proteomes:UP000095285}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA   Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA   Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Loa loa.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:EN70_7495}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
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DR   AlphaFoldDB; A0A1I7VXY2; -.
DR   STRING; 7209.A0A1I7VXY2; -.
DR   WBParaSite; EN70_7495; EN70_7495; EN70_7495.
DR   Proteomes; UP000095285; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR015526; Frizzled/SFRP.
DR   InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR   InterPro; IPR036790; Frizzled_dom_sf.
DR   PANTHER; PTHR11309; FRIZZLED; 1.
DR   PANTHER; PTHR11309:SF23; FRIZZLED-4; 1.
DR   Pfam; PF01534; Frizzled; 1.
DR   PRINTS; PR00489; FRIZZLED.
DR   SMART; SM01330; Frizzled; 1.
DR   SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095285};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        127..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          115..248
FT                   /note="Frizzled/Smoothened 7TM"
FT                   /evidence="ECO:0000259|SMART:SM01330"
SQ   SEQUENCE   248 AA;  28736 MW;  ED67AA47161F4E87 CRC64;
     MQKIFAFLGT AVLITLQHLQ VKRDCVSILM EFGIDWPEPL NCSRFPEAPN LCMKPTNDQN
     SYLGPEQFDA DHREPVPSLE ERIFSKTMTS CPHDLVNLDP TDRRGLCVFQ CNREGMFDVS
     KKEFARFWML LWASVNLGVT AFTVLTFIID RQRFRFPERS VFYLSACYML FSLPPLSRAV
     FPYERIVCDK LPTGQMFLIV GTLDNTSCVT WQCYYEGKHC SAYAVMHNDD ILIHLENRQK
     TGKTEMKN
//