ID   A0A1I7VYT8_LOALO        Unreviewed;       722 AA.
AC   A0A1I7VYT8;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=Xenotropic and polytropic retrovirus receptor 1 {ECO:0000313|WBParaSite:EN70_778};
OS   Loa loa (Eye worm) (Filaria loa).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX   NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_778};
RN   [1] {ECO:0000313|Proteomes:UP000095285}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA   Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA   Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Loa loa.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:EN70_778}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SYG1 (TC 2.A.94) family.
CC       {ECO:0000256|ARBA:ARBA00009665}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_003144071.1; XM_003144023.1.
DR   AlphaFoldDB; A0A1I7VYT8; -.
DR   STRING; 7209.A0A1I7VYT8; -.
DR   WBParaSite; EN70_778; EN70_778; EN70_778.
DR   Proteomes; UP000095285; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd14477; SPX_XPR1_like; 1.
DR   InterPro; IPR004342; EXS_C.
DR   InterPro; IPR004331; SPX_dom.
DR   PANTHER; PTHR10783:SF103; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1; 1.
DR   PANTHER; PTHR10783; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED; 1.
DR   Pfam; PF03124; EXS; 1.
DR   Pfam; PF03105; SPX; 2.
DR   PROSITE; PS51380; EXS; 1.
DR   PROSITE; PS51382; SPX; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095285};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        235..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        277..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        317..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        343..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        528..546
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..179
FT                   /note="SPX"
FT                   /evidence="ECO:0000259|PROSITE:PS51382"
FT   DOMAIN          458..662
FT                   /note="EXS"
FT                   /evidence="ECO:0000259|PROSITE:PS51380"
SQ   SEQUENCE   722 AA;  84467 MW;  672BB0E124C7FDE9 CRC64;
     MKFGEQLSSH LTPEWRKQYI RYEALKSMLY EMMAGLPTEP EAREQYVSRM DEKFFAECER
     ELTKINLFYS QKIAEAQGKF HELNAELMAF KEALENREIQ SVTDSAPLRQ RIKRHSISVR
     NITREHAKTS QQLKLAFSEF YLALVLLQNY QQLNATGFRK ILKKHDKLME NERGLDWRIS
     RVEKSSFFLN REVETLINNV ERDVINDLEG GNRQAGMKRL KVPPLSEKQH ATTTFTLGLF
     LGAFVVLGIA IIISWFASEP RPTEPKWVAV RLFRGPLLLF VAIWLCGLNM WGWAEAGVNH
     VLIFEVDPRN HLTYQSVMQI ASFMCMLWSL GVLGYLYCHL IHLPPFLFPL LLMIICVIYI
     FNPLKKPNSI FQRNSRFWIL KHCFSCFTAP LHFVTFIDFW LGDQMNSLVT SFLDFQYFIC
     FYTTEVDYTD WTLSARTVNM TISEPIPWGY VDISTGRDMC TSSSGIRVLV SIFPATVRFM
     QCLRRFRDTG HAHPHLINAG KYSTTYLVVF FKSLNHWAEK TDPTATSIFF YLWIASYIFS
     FAYTFLWDIF MDWGLIDPLA PKDSPFLREE MIYGSKWYYY GAIVEDFILR LSWVLNISLG
     EAWTMESDLL TCITAPLEVF RRFIWNYFRL ENEHINNCGQ FRAVRDISVK PIKKGDLESL
     LLKMDEENGV SHRGQDLRLR VKKQKKSSRS RRQILRRARF ARIAIGYHPN STSSPAIVET
     RH
//