ID   A0A1I7VZU2_LOALO        Unreviewed;      1214 AA.
AC   A0A1I7VZU2;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=Splicing factor 3B subunit 3 {ECO:0000256|ARBA:ARBA00040929};
OS   Loa loa (Eye worm) (Filaria loa).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX   NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_8118};
RN   [1] {ECO:0000313|Proteomes:UP000095285}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA   Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA   Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Loa loa.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:EN70_8118}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the RSE1 family.
CC       {ECO:0000256|ARBA:ARBA00038266}.
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DR   AlphaFoldDB; A0A1I7VZU2; -.
DR   STRING; 7209.A0A1I7VZU2; -.
DR   WBParaSite; EN70_8118; EN70_8118; EN70_8118.
DR   eggNOG; KOG1898; Eukaryota.
DR   Proteomes; UP000095285; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR   InterPro; IPR004871; Cleavage/polyA-sp_fac_asu_C.
DR   InterPro; IPR018846; Cleavage/polyA-sp_fac_asu_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR10644; DNA REPAIR/RNA PROCESSING CPSF FAMILY; 1.
DR   PANTHER; PTHR10644:SF1; SPLICING FACTOR 3B SUBUNIT 3; 1.
DR   Pfam; PF03178; CPSF_A; 1.
DR   Pfam; PF10433; MMS1_N; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095285}.
FT   DOMAIN          77..593
FT                   /note="Cleavage/polyadenylation specificity factor A
FT                   subunit N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF10433"
FT   DOMAIN          860..1180
FT                   /note="Cleavage/polyadenylation specificity factor A
FT                   subunit C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03178"
FT   COILED          807..834
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1214 AA;  135136 MW;  24713B7D87BC0A81 CRC64;
     MYLYNLTLQG SSAINQAIHG SFCGLPKQQE VCIARGNLLQ LLFCDPKTGK IHILCSHNAF
     GIIRSLLAFR LTGGTKDYIV VGSDAGRIVI LEYNTQKVCF ERVHQETFGK TGCRRIVPGQ
     FLAIDPKGRA ILIGAVERQK LVYIMNRDAS ANLTISSPLE AHKSHCICYS VVGVDVGFEN
     PTFACLEVDY EEVDHDSTGH LATKIPQTLT FYELDLGLNH VVRKYAEPLV DKGNILISVP
     GGQDGPSGVI VCCENYLVYK NLGDQPDIKC PVPRRRNELD DCDRTVIIVC AATHKTKLMY
     FFLVQTDQGD IFKVTLESEH DIVTELKIKY FDTIPVSNAM CILKTGFLFT ASEFGNHHLY
     QIAHLGDEDD EPEFSSRMQL EEGETFFFAP RGLTNLAVVD QMDSLSPLIS SYIDDLANED
     SPQIYTLIGR GALSAVKVLR NGLEVTEMAV SELPGNPNAV WTVKRNIDDK FDSHIVVSFV
     NATLVLSIGE TVEEVTDSGF LGTTPTLGCA LIGDDALLQV YPDGIRHIRA DRRVNEWKAP
     GKRTIMKCAL NRRQVAIALA GGELVYFELD VTGQLNEYTE RRELPADVLC MSLSEIPEGE
     LRSRFLTVGL ADKTVRIISL DPQDCLSPLS MQALPSEPES IIVLEMFGTE TQSASTVHLN
     IGLQNGCLLR TTVDQVTGEL TDNRTRYLGT KSVKLFHVRI QSKDAIMAAS SRAWLLYDYQ
     SRFHLTPLSY AALEFAAGFS SEQCPEGIVA IAENTLRILS LEKLGAVFNH VVHPLDYTPR
     RMVVHKASGN LIIIENDHAA FTVKGKMERR KQLADELMEV AKEAEEADQQ AVKEMADAIR
     TEKVDERVYG SPKNQKGKWA STVRVMRSND GETLSHFPFA EDEAAFAIAM VQFQNQSDTQ
     FVLVGCGCEL QLKPRKANGG CIYTFLLAAN GTTLQLLHRT ATDEVVNAIH DFRGMALAGV
     GKKVRLYDLG KRKLLAKCEN RQIPTQVVDI RSMGQRIVVS DSQESVHFMR YKKQDGQLSI
     FCDETSPRYV TCVCLLDYDT VAVGDRFGNI AVLRLPKGVT EEVQEDPTGV RALWDRGNLN
     GASQKLEAIA HLYIGDAITS MQKTSLVPGA NDCLCYTTIS GIIGILVPFM SRDEFEFFQN
     LEMHMRVEYP PLCGRDHLAY RSYYFPVKSI IDGDLCEQYS LMPLDKQKSV GEELGRKSTE
     IHKKLEDIRT RYAF
//