ID   A0A1I7W0M0_LOALO        Unreviewed;       361 AA.
AC   A0A1I7W0M0;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Reverse transcriptase domain-containing protein {ECO:0000313|WBParaSite:EN70_8347};
OS   Loa loa (Eye worm) (Filaria loa).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX   NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_8347};
RN   [1] {ECO:0000313|Proteomes:UP000095285}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA   Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA   Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Loa loa.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:EN70_8347}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
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DR   AlphaFoldDB; A0A1I7W0M0; -.
DR   STRING; 7209.A0A1I7W0M0; -.
DR   WBParaSite; EN70_8347; EN70_8347; EN70_8347.
DR   Proteomes; UP000095285; Unassembled WGS sequence.
DR   CDD; cd01644; RT_pepA17; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR008042; Retrotrans_Pao.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR22955; RETROTRANSPOSON; 1.
DR   PANTHER; PTHR22955:SF69; RNA-DIRECTED DNA POLYMERASE; 1.
DR   Pfam; PF05380; Peptidase_A17; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000095285}.
FT   DOMAIN          100..314
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
SQ   SEQUENCE   361 AA;  41691 MW;  55E4513437D6A61F CRC64;
     MDQIEQTWKL EVIGIKDLMT EYQEDKALEA FQKSLTVNSE GRCVVGWPWK NQEITPAEGY
     GLALGRLRST IRRLKRSPEL LECYDEYFKN LLEEGVIEKI KNQNETSRIS YLPHQAVVTP
     QKSTTKLRVV FDASAKTNEG PSLNECLYKG PVMLPLLIGI LLRARQGRYL VIADVEKAFL
     QVSLKQEDRD VTRFLWLKDK SKEAIKENLV IFRFTRVPFG VVSSPFLLAA VIRHLLSEEN
     SELSKEIAEN LYVDNVVLTS ESEAESTKKA KEAKELFKKI KMQLREFHAN HDININNEQE
     MTDETKVKLL GIEWNTSKDK FIWNWKIPQG GLQTKRQILQ FYAAIYDPLG LLSPIILPWK
     F
//