ID   A0A1I7W2M7_LOALO        Unreviewed;       509 AA.
AC   A0A1I7W2M7; A0A1S0U2K6;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=E2F_TDP domain-containing protein {ECO:0000313|WBParaSite:EN70_9004};
GN   ORFNames=LOAG_05011 {ECO:0000313|EMBL:EFO23475.2,
GN   ECO:0000313|WBParaSite:EN70_9004};
OS   Loa loa (Eye worm) (Filaria loa).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX   NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_9004};
RN   [1] {ECO:0000313|EMBL:EFO23475.2, ECO:0000313|Proteomes:UP000095285}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA   Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA   Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Loa loa.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:EN70_9004}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU003796}.
CC   -!- SIMILARITY: Belongs to the E2F/DP family.
CC       {ECO:0000256|ARBA:ARBA00010940, ECO:0000256|RuleBase:RU003796}.
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DR   EMBL; JH712431; EFO23475.2; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I7W2M7; -.
DR   STRING; 7209.A0A1I7W2M7; -.
DR   EnsemblMetazoa; EFO23475.2; EFO23475.2; LOAG_05011.
DR   WBParaSite; EN70_9004; EN70_9004; EN70_9004.
DR   eggNOG; KOG2577; Eukaryota.
DR   InParanoid; A0A1I7W2M7; -.
DR   OMA; RWKSNDE; -.
DR   OrthoDB; 1761at2759; -.
DR   Proteomes; UP000095285; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd14660; E2F_DD; 1.
DR   Gene3D; 6.10.250.540; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR015633; E2F.
DR   InterPro; IPR037241; E2F-DP_heterodim.
DR   InterPro; IPR032198; E2F_CC-MB.
DR   InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR12081; TRANSCRIPTION FACTOR E2F; 1.
DR   PANTHER; PTHR12081:SF18; TRANSCRIPTION FACTOR E2F2; 1.
DR   Pfam; PF16421; E2F_CC-MB; 1.
DR   Pfam; PF02319; E2F_TDP; 1.
DR   SMART; SM01372; E2F_TDP; 1.
DR   SUPFAM; SSF144074; E2F-DP heterodimerization region; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003796};
KW   Nucleus {ECO:0000256|RuleBase:RU003796};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095285};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU003796};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU003796}.
FT   DOMAIN          196..262
FT                   /note="E2F/DP family winged-helix DNA-binding"
FT                   /evidence="ECO:0000259|SMART:SM01372"
FT   REGION          40..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          103..182
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          276..303
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        61..90
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        103..166
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   509 AA;  56124 MW;  82DF90DB71AB3BDD CRC64;
     MAAASSTQPS LYQHYFTEHL SSNSSIIVNN VTGLNSEAKS TAWSSPVAGK QFDGDSEMNV
     RNGRSEGSSW TNNLAATSFM PSSTDGQNSC SISSYGEWNS DISNSERYSS QNTSQQMMST
     TPKRRKSEMA TASAAGNSEP HSANPRFNDT QGSSSSQALL HSESDSHPRP TSSRKRHAGA
     AGETLSAAQF GPLNCRVDNS LLVLTKKFMQ LQPQANEDGL LNLNEAAMRL GVQKRRLYDI
     TNVLEGIDMI EKMGKNSIRW KSNDEIGSRG IEAQRLKEEI KSLDKYEQSL DELITSIENA
     LKLAKEDPTD RVYSYVKYAD LRMLPGMSDQ TLIAIKAPKD SYSSIDVTDP VETGKFEIMI
     KNSQKEPLEA YLCPHLSPKN EQFEKEESRD AMVHEDQRSW SEQSTNDVFQ EITGDAQQQV
     PIPGPSNDNN ANILSVNALS TFYAPPNLHT SPLKMVVEGP SQQAVSSSNT EDTAANSYAL
     LSLDPVDESE PYMYSIGEQE SIQTLYDWP
//