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Database: UniProt
Entry: A0A1I7W309_LOALO
LinkDB: A0A1I7W309_LOALO
Original site: A0A1I7W309_LOALO 
ID   A0A1I7W309_LOALO        Unreviewed;       374 AA.
AC   A0A1I7W309; A0A1S0TRC6;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   31-JUL-2019, entry version 19.
DE   RecName: Full=PKS_ER domain-containing protein {ECO:0000259|SMART:SM00829};
GN   ORFNames=LOAG_09629 {ECO:0000313|EMBL:EFO18868.1,
GN   ECO:0000313|WBParaSite:EN70_9083};
OS   Loa loa (Eye worm) (Filaria loa).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX   NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_9083};
RN   [1] {ECO:0000313|EMBL:EFO18868.1}
RP   NUCLEOTIDE SEQUENCE.
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA   Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E.,
RA   Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E.R.,
RA   Heiman D., Howarth C., Mehta T., Neiman D., Pearson M., Roberts A.,
RA   Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., White J.,
RA   Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Loa loa.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_9083}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25217238; DOI=10.1186/1471-2164-15-788;
RA   Tallon L.J., Liu X., Bennuru S., Chibucos M.C., Godinez A., Ott S.,
RA   Zhao X., Sadzewicz L., Fraser C.M., Nutman T.B., Dunning Hotopp J.C.;
RT   "Single molecule sequencing and genome assembly of a clinical specimen
RT   of Loa loa, the causative agent of loiasis.";
RL   BMC Genomics 15:788-788(2014).
RN   [3] {ECO:0000313|WBParaSite:EN70_9083}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
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DR   EMBL; JH712372; EFO18868.1; -; Genomic_DNA.
DR   RefSeq; XP_003145204.1; XM_003145156.1.
DR   STRING; 7209.EFO18868.1; -.
DR   EnsemblMetazoa; EFO18868.1; EFO18868.1; LOAG_09629.
DR   GeneID; 9947068; -.
DR   KEGG; loa:LOAG_09629; -.
DR   WBParaSite; EN70_9083; EN70_9083; EN70_9083.
DR   CTD; 9947068; -.
DR   KO; K13949; -.
DR   OMA; SFNWPWQ; -.
DR   OrthoDB; 884151at2759; -.
DR   Proteomes; UP000095285; Unassembled WGS sequence.
DR   GO; GO:0047522; F:15-oxoprostaglandin 13-oxidase activity; IEA:InterPro.
DR   GO; GO:0006693; P:prostaglandin metabolic process; IEA:InterPro.
DR   CDD; cd08293; PTGR2; 1.
DR   InterPro; IPR013149; ADH_C.
DR   InterPro; IPR041694; ADH_N_2.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR037399; PTGR2.
DR   Pfam; PF16884; ADH_N_2; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; SSF50129; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000095285};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095285}.
FT   DOMAIN       60    369       PKS_ER. {ECO:0000259|SMART:SM00829}.
SQ   SEQUENCE   374 AA;  40982 MW;  4F4929A01478856C CRC64;
     MEHMNENQTQ CCSYSRNSNC LSYNKRIVFV RRPGANNFPS ADCFRCEDCL APNRLDVGNG
     QCIVRTLYLS VDPAQRCRMN KSTGVDYLAS YEIGELVDGL EGIGIIEMVS PDSTFKVGDL
     VTSIGRLWPW SRLFVADQID LVRVTLPPGF SPSIILSCVG LSGLTALLGI QKKAEIDPTQ
     PQTFVVSGAA GSCGSLAGQI ARLYGCTKVI GICGSDQKCA VLLNEWNFNG AINYKRESVV
     DRLHKLAPEG VDIYFDNVGG FVSDAVISLM NKGGRVVLCG QIAVYNTDLP NPPPLPEKTA
     QIIAERKIKR EKFIVLQYKD DIDASVAQLS TWLQEKKLKS RETVYEGLER APEAVIDLLN
     GCNIGKMIVK VDDS
//
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