ID A0A1I7W486_LOALO Unreviewed; 539 AA.
AC A0A1I7W486; A0A1S0TYI6;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Rab5 GDP/GTP exchange factor {ECO:0000313|EMBL:EFO22399.2, ECO:0000313|WBParaSite:EN70_9447};
GN ORFNames=LOAG_06089 {ECO:0000313|EMBL:EFO22399.2,
GN ECO:0000313|WBParaSite:EN70_9447};
OS Loa loa (Eye worm) (Filaria loa).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_9447};
RN [1] {ECO:0000313|EMBL:EFO22399.2, ECO:0000313|Proteomes:UP000095285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Genome Sequencing Center for Infectious Disease;
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Loa loa.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:EN70_9447}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
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DR EMBL; JH712187; EFO22399.2; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I7W486; -.
DR STRING; 7209.A0A1I7W486; -.
DR EnsemblMetazoa; EFO22399.2; EFO22399.2; LOAG_06089.
DR WBParaSite; EN70_9447; EN70_9447; EN70_9447.
DR eggNOG; KOG2319; Eukaryota.
DR eggNOG; KOG3173; Eukaryota.
DR InParanoid; A0A1I7W486; -.
DR OMA; MNMGCNQ; -.
DR OrthoDB; 20678at2759; -.
DR Proteomes; UP000095285; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.10.246.120; -; 1.
DR Gene3D; 1.20.5.4770; -; 1.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR InterPro; IPR041545; DUF5601.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR045046; Vps9-like.
DR InterPro; IPR037191; VPS9_dom_sf.
DR InterPro; IPR002653; Znf_A20.
DR PANTHER; PTHR23101; RAB GDP/GTP EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23101:SF122; RAB5 GDP_GTP EXCHANGE FACTOR; 1.
DR Pfam; PF18151; DUF5601; 1.
DR Pfam; PF02204; VPS9; 1.
DR Pfam; PF01754; zf-A20; 1.
DR SMART; SM00167; VPS9; 1.
DR SMART; SM00259; ZnF_A20; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS51205; VPS9; 1.
DR PROSITE; PS51036; ZF_A20; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000095285};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 28..62
FT /note="A20-type"
FT /evidence="ECO:0000259|PROSITE:PS51036"
FT DOMAIN 242..386
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT REGION 511..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 425..459
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 539 AA; 60661 MW; 533DECDE724D7C6C CRC64;
MNNTEIESGT EKLLKSSSSD KRLRVQITEG DLLCVNRCGF YGTPQWKGRC SKCWRAYQME
EKKTQCYTKN RELISFEKFE GRRRPSTESR SLTLKSILRK SPSISANSNP SQEIVCTAAP
SQSALTSPVT PLRHRLSEGS ISAYDHFHEF LQNNLPQAAA HEIAQQTHHA VDKILEQQNV
NMDDLSSMVQ HFYQVLADKM RHSPIMNDSV VSVSVEEVMA EVEQYICVRA YSTLFCARAD
EESADLSLQD RIRSLNWVTA GFLETTLDFS QESVRDKLDE AITEIIDMNS RRGAAEKLQC
LVRCSKMIFE ALKESRSGAP AGADEYLPVL IFVILKGNPP LIQSNVKFVS RFALPVRVLS
GESGYYFTNV SCALQFVQNM NAESLKMPKQ EFEAYTSGRE VPPLNAMNMG CNQSIRTMEN
SLVLVRQLLE KQKNLKGRIN ELEIRVKRET GELSAEIDEI LNMYPSEELK HLAEQIMIEE
AELFGSLSAP SSILLNASQS SRVLDFIDDD NADIEDHDDD CEKDVTTSQS QASSIQNSA
//
