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Database: UniProt
Entry: A0A1I7W4H8_LOALO
LinkDB: A0A1I7W4H8_LOALO
Original site: A0A1I7W4H8_LOALO 
ID   A0A1I7W4H8_LOALO        Unreviewed;      1153 AA.
AC   A0A1I7W4H8; A0A1S0TZA7;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE            EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN   ORFNames=LOAG_05850 {ECO:0000313|EMBL:EFO22634.2,
GN   ECO:0000313|WBParaSite:EN70_9529};
OS   Loa loa (Eye worm) (Filaria loa).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX   NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_9529};
RN   [1] {ECO:0000313|EMBL:EFO22634.2, ECO:0000313|Proteomes:UP000095285}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA   Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA   Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Loa loa.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:EN70_9529}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620; EC=3.1.3.48;
CC         Evidence={ECO:0000256|ARBA:ARBA00001490};
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DR   EMBL; JH712275; EFO22634.2; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I7W4H8; -.
DR   STRING; 7209.A0A1I7W4H8; -.
DR   EnsemblMetazoa; EFO22634.2; EFO22634.2; LOAG_05850.
DR   WBParaSite; EN70_9529; EN70_9529; EN70_9529.
DR   eggNOG; KOG4228; Eukaryota.
DR   InParanoid; A0A1I7W4H8; -.
DR   OMA; SHYWLIV; -.
DR   OrthoDB; 2875525at2759; -.
DR   Proteomes; UP000095285; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR   CDD; cd00063; FN3; 1.
DR   CDD; cd14553; R-PTPc-LAR-1; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000242; PTP_cat.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR000387; Tyr_Pase_dom.
DR   PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR   PANTHER; PTHR19134:SF531; TYROSINE-PROTEIN PHOSPHATASE LAR; 1.
DR   Pfam; PF00041; fn3; 1.
DR   Pfam; PF00102; Y_phosphatase; 2.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM00060; FN3; 2.
DR   SMART; SM00194; PTPc; 2.
DR   SMART; SM00404; PTPc_motif; 2.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR   SUPFAM; SSF49265; Fibronectin type III; 2.
DR   PROSITE; PS50853; FN3; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095285};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        446..470
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          36..135
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          596..851
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS50055"
FT   DOMAIN          771..842
FT                   /note="Tyrosine specific protein phosphatases"
FT                   /evidence="ECO:0000259|PROSITE:PS50056"
FT   DOMAIN          883..1142
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS50055"
FT   DOMAIN          1057..1133
FT                   /note="Tyrosine specific protein phosphatases"
FT                   /evidence="ECO:0000259|PROSITE:PS50056"
SQ   SEQUENCE   1153 AA;  132373 MW;  3873754E041E567B CRC64;
     MKYRRSLKAV QQQNIFAAVI RQFLGYHKSN NATIYPPSNV RVQATSNTSA VVQWDLDNGR
     NVDGFVIRYI HEPVSGQRDN ERWKTITIMN PSARHLHISQ LTAHKPYAFC VLAIRQNRQG
     TCSDPPTTID RLQATHMVSN LLIAWKTSNS VMLRWEYTGP QPVGFYVNQT GRKDYLDQNL
     QLKGMISPGF RQDLDGHQRE YLWTTLRPYM EYTFHVGVRE LPPGGREYWP REVIVRTDPT
     GPPFVDVPEF ITSNSANTAL IRLKCASEEY GPISHYWLIV LPGNFTQDDV LNLDSTSLQR
     STTMMRPNQN KNYYGKTSKK VRKVNREQDY KGRYLHEPFT LRGAYIAAGI PVHEMQQIQR
     SDQLFALGDG RMYDGYDNWP LNSNTKYRLM MRAFARDDIS RNSDYPFEFR APIQEPLAKR
     YSDSMLSEPF STKAAAHIRD AKTSNLWLIA PIIAILIIAI ILGMLIIWWL RCNRRNNRHK
     TSHHGSISKI ALTSNTIPSE TSKLLVSGDV YGRHIVNPYD QMNGNGGCTM DTAMDMYPLH
     QSHMSSGTYN PLPVPMSILP SSGGAVGGHS LTHLPIPISE LAAHIDKLKM NNNALFSQEY
     ESIETGQHFT WENSSLPINK MKNRYANVVA YDHSRVILSI IDDIEGSDYI NANYIDGYEK
     PKAYIATQGP LPETFADFWR MVWEENTVTI VMLTKLEERS RLKCNQYWPA RGSSYYGHIQ
     VTLLDTLELA HYTIRTFRLQ YRSGGKVREI RHLQYTAWPD HGVPDHPTPF LMFLKRVKTL
     NRPDAGPIIS HCSAGIGRTG AFIVIDCMLE RLRYENTVDI YGCVTALRSQ RSYMVQTDDQ
     YIFIHDAVLD AVQSGSTEVP ASKLYTHVQA LLQIQPIDQV SAMELEFRHL ATMKMSNSRC
     SIANLSINRP KNRLINMVPY DSSRVILRSI PGEEGSDYIN ASWIDGYRQR SAYIATQGPM
     PYTVNDFWRM IWEHESSIIV MLVRTMETCR EKCYEYWPAE LGAQFGYLVV EPIAEYNMSQ
     YVLREFRITD TESGQTKTLR HFQYVEWPDH CPPKSAELFI DFIHQVHRTK TQFGVDGPIT
     VHCSTGAGRT GVFIALSIII DRMKLEHVVD VFTTVKLLRT ERQNMVQDKD QYHFCYQAAL
     EFLATYDNPY QMS
//
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