ID A0A1I7W4H8_LOALO Unreviewed; 1153 AA.
AC A0A1I7W4H8; A0A1S0TZA7;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN ORFNames=LOAG_05850 {ECO:0000313|EMBL:EFO22634.2,
GN ECO:0000313|WBParaSite:EN70_9529};
OS Loa loa (Eye worm) (Filaria loa).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_9529};
RN [1] {ECO:0000313|EMBL:EFO22634.2, ECO:0000313|Proteomes:UP000095285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Genome Sequencing Center for Infectious Disease;
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Loa loa.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:EN70_9529}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
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DR EMBL; JH712275; EFO22634.2; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I7W4H8; -.
DR STRING; 7209.A0A1I7W4H8; -.
DR EnsemblMetazoa; EFO22634.2; EFO22634.2; LOAG_05850.
DR WBParaSite; EN70_9529; EN70_9529; EN70_9529.
DR eggNOG; KOG4228; Eukaryota.
DR InParanoid; A0A1I7W4H8; -.
DR OMA; SHYWLIV; -.
DR OrthoDB; 2875525at2759; -.
DR Proteomes; UP000095285; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 1.
DR CDD; cd14553; R-PTPc-LAR-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF531; TYROSINE-PROTEIN PHOSPHATASE LAR; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000095285};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 446..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..135
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 596..851
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 771..842
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 883..1142
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1057..1133
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1153 AA; 132373 MW; 3873754E041E567B CRC64;
MKYRRSLKAV QQQNIFAAVI RQFLGYHKSN NATIYPPSNV RVQATSNTSA VVQWDLDNGR
NVDGFVIRYI HEPVSGQRDN ERWKTITIMN PSARHLHISQ LTAHKPYAFC VLAIRQNRQG
TCSDPPTTID RLQATHMVSN LLIAWKTSNS VMLRWEYTGP QPVGFYVNQT GRKDYLDQNL
QLKGMISPGF RQDLDGHQRE YLWTTLRPYM EYTFHVGVRE LPPGGREYWP REVIVRTDPT
GPPFVDVPEF ITSNSANTAL IRLKCASEEY GPISHYWLIV LPGNFTQDDV LNLDSTSLQR
STTMMRPNQN KNYYGKTSKK VRKVNREQDY KGRYLHEPFT LRGAYIAAGI PVHEMQQIQR
SDQLFALGDG RMYDGYDNWP LNSNTKYRLM MRAFARDDIS RNSDYPFEFR APIQEPLAKR
YSDSMLSEPF STKAAAHIRD AKTSNLWLIA PIIAILIIAI ILGMLIIWWL RCNRRNNRHK
TSHHGSISKI ALTSNTIPSE TSKLLVSGDV YGRHIVNPYD QMNGNGGCTM DTAMDMYPLH
QSHMSSGTYN PLPVPMSILP SSGGAVGGHS LTHLPIPISE LAAHIDKLKM NNNALFSQEY
ESIETGQHFT WENSSLPINK MKNRYANVVA YDHSRVILSI IDDIEGSDYI NANYIDGYEK
PKAYIATQGP LPETFADFWR MVWEENTVTI VMLTKLEERS RLKCNQYWPA RGSSYYGHIQ
VTLLDTLELA HYTIRTFRLQ YRSGGKVREI RHLQYTAWPD HGVPDHPTPF LMFLKRVKTL
NRPDAGPIIS HCSAGIGRTG AFIVIDCMLE RLRYENTVDI YGCVTALRSQ RSYMVQTDDQ
YIFIHDAVLD AVQSGSTEVP ASKLYTHVQA LLQIQPIDQV SAMELEFRHL ATMKMSNSRC
SIANLSINRP KNRLINMVPY DSSRVILRSI PGEEGSDYIN ASWIDGYRQR SAYIATQGPM
PYTVNDFWRM IWEHESSIIV MLVRTMETCR EKCYEYWPAE LGAQFGYLVV EPIAEYNMSQ
YVLREFRITD TESGQTKTLR HFQYVEWPDH CPPKSAELFI DFIHQVHRTK TQFGVDGPIT
VHCSTGAGRT GVFIALSIII DRMKLEHVVD VFTTVKLLRT ERQNMVQDKD QYHFCYQAAL
EFLATYDNPY QMS
//