ID A0A1I7W6G7_HETBA Unreviewed; 846 AA.
AC A0A1I7W6G7;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Neur_chan_LBD domain-containing protein {ECO:0000313|WBParaSite:Hba_00194};
OS Heterorhabditis bacteriophora (Entomopathogenic nematode).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Heterorhabditidae;
OC Heterorhabditis.
OX NCBI_TaxID=37862 {ECO:0000313|Proteomes:UP000095283, ECO:0000313|WBParaSite:Hba_00194};
RN [1] {ECO:0000313|WBParaSite:Hba_00194}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Postsynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034104}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
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DR AlphaFoldDB; A0A1I7W6G7; -.
DR WBParaSite; Hba_00194; Hba_00194; Hba_00194.
DR Proteomes; UP000095283; Unplaced.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022848; F:acetylcholine-gated monoatomic cation-selective channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR PANTHER; PTHR18945:SF471; ACETYLCHOLINE RECEPTOR SUBUNIT BETA-TYPE UNC-29; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00254; NICOTINICR.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 406..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 671..694
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 799..823
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 521..653
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 753..815
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
SQ SEQUENCE 846 AA; 97068 MW; 3F7847DA9472FB51 CRC64;
MLADIYPDSS QALHGDKEAK FHTSMEHYIY IYIYILGGLI NASVGANNIS HSEGKNICVA
SVRESENPST ISLKSQWKST SRTGIKMKSK KTESLAGQFS GSQLKLTQGI NDIPVLNTYD
CCLSRVRLSD YNLLKKSDWK FVNGGCKTEP SSSNSEDISK AFEGINISME NKDEKLESFI
LPTFSKEELD ALQLPKHFGP QVNSRGQIRS RKRRNSGDKA QNWLRNATFE EYWEVCTCFI
KVNNGFAFMK IEIHINLMNF FQSASWYLIY KTWLRDYGDV MSADCREKLE RDIDSYKPIA
LLEEHDSEVE NMGFVPGYSE ADFSSPLNEQ DLCKDEKKAV AQKQPSYQRF PIVYGDDEVL
FVKKYLVLVQ LLIVFLNYRS GWFSVTPERI AEHIADRMVR RQGIVIGQNC FILYSTLMII
LSFNYSYDLF CFQLISLAGP GGRCEIEQSC LNNKIKTITA YYGNFAHAFH PIVIGIFQSY
SWSCFSVTDP NLVSIEMVNW NYEHPNDKDD YEEFVVASDD EERLMVDVFR GYNSLIQPVK
NISETPIIVK IALQLVLLIN VDEKDQVMHT NVWLTLKWHD FQMRWNPVNY GEIRQIRVSP
DKVWLPDIVL FNNADGNYEV SFMCNVVINH LGEMLWVPPA IYKSSCIIVH NHFHYKLSII
SLTTNFMRKT LFYTVVLIIP TVLMAFLSMA VFFLPTDSGG SKSNRLLDIH LNLAQMRSFL
NVLPRIRNLT LSRTVSTKVL HSPSEIDHDP TTSAFYPLSP DALRAIDAIE YITDHLKQDE
EYKMYRDDWK YVAMIIDRLL LYVFFGITVG GTCGILFSAP YVFHGVNQRE VLQKLIDLYK
TGGSSS
//
