ID   A0A1I7WZU0_HETBA        Unreviewed;      1595 AA.
AC   A0A1I7WZU0;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=HET domain-containing protein {ECO:0000313|WBParaSite:Hba_10659};
OS   Heterorhabditis bacteriophora (Entomopathogenic nematode).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Heterorhabditidae;
OC   Heterorhabditis.
OX   NCBI_TaxID=37862 {ECO:0000313|Proteomes:UP000095283, ECO:0000313|WBParaSite:Hba_10659};
RN   [1] {ECO:0000313|WBParaSite:Hba_10659}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   WBParaSite; Hba_10659; Hba_10659; Hba_10659.
DR   Proteomes; UP000095283; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR   InterPro; IPR003152; FATC_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR   PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR   PANTHER; PTHR11139:SF71; SERINE_THREONINE-PROTEIN KINASE SMG1; 1.
DR   Pfam; PF02260; FATC; 1.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
DR   SMART; SM01343; FATC; 1.
DR   SMART; SM00146; PI3Kc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS51190; FATC; 1.
DR   PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777}; Membrane {ECO:0000256|SAM:Phobius};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        1549..1568
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1065..1452
FT                   /note="PI3K/PI4K catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50290"
FT   DOMAIN          1563..1595
FT                   /note="FATC"
FT                   /evidence="ECO:0000259|PROSITE:PS51190"
SQ   SEQUENCE   1595 AA;  180848 MW;  C5C1A6E190AD8669 CRC64;
     MGQSRVTAST FGSEDFVILT DFLLRKVVPS YHRDQNNEAN WLVDTIEILY ANCQLEGCVP
     KPDSDKKIDI AQVIYAINDI QTYISAMVVA YNNGYYAQVI RFGSSALLDL EKKQQRVEAS
     LKEEQAARGL SAWVKRVYHV EMRWIDASVE IAAARYESSL VLLRGCLEDP EVPESVKTIL
     RDMKLNVLSR LRLPLLLDPL KCPPDLSIWN EADRLNGQNP AGFDAEALLR FVTDILICYF
     NLDKKWKNFR VKQLSFFGKI ERIENSPSVK WNLEEAMMRC ELHLMQTLRR VDVVQLREEL
     AALARGVLLS DGGQRLHGRI AAVNHIAGTV LKKMHRKGHP EIDINSNILD ELSASFLLEE
     CDEIGERLRL ARQLTLWAER LGGSSPAHLH FPVARLARKT GNPLLAGLHL HKASGNPTLI
     QGSPALTHLR VAIQGTKMMW PIATAEQRAR DFAAVFMALV GAYEIDNHSR QLANINGDFN
     GSVDAVNNGF LNGFAPHIGE FIIVPTVYPT GLTEVSLNAS LSNEMARAAL HLAKWLDENP
     HVISALPSDC RMSRYWMQLE NVRRELGSDL VGSLLVTSTN MTPHLAKAHR RLADWAFRAA
     EGAAIQKDRT LFDQNYRVNL SHIYSLVMHI SILFIYIQIF LGTNIDQCVL DGLWTAVSSA
     NSVAQLGDDV MTIMGNDVLT AKSLLETNSY YTNLWLQIRQ RRAVYYNLAV SSYFSFISQM
     GSAGGSHCGT IGSVSVTLRI LALLVKHSDF LHEAIDRGLQ TTNEHLWKGS LISEYNQKLR
     VIANILPQLF ARLSHPVREV RESLIALLSR LCYSAPHVLV FQVVTGASSC MLVDDSDDVI
     EATEKEEDEN TSKERCLMFE CCRHLVSVLD AHFPNLVHDV REFVNELQRI NLLNEERWAF
     VLSNLDHEME KRLDQIRIES EKTVTASHLD EKTRLELIAE KSRLITTSVY RILDDLYERT
     CMRDPATPNE KTFIDMYGEQ LRAVFEQSRA NRKSPEKAWA PFKQILGLLL QRTSRRGGHV
     LQMSDISAVL TNVSLNSLHK LSKWCVPIPG QESVEYSQVV SIDRVVRNAI VLPTKTRPKK
     IAFIAVQSSK YFPSRFIKQH TLHIPPDTQK NFFWRECSAL PWMLLAVRGL PMNMLTIFHK
     KFFLRCLASN EMQMLSRRPM LFSESSYGTH FPSLRIFPIS CNRLETVVLS TANCYASPFR
     VCDGFSTYND FKASVFAVRG ISERCRSLTS NSTEHIDLHA SAAFFPCWNS LEQHQQLLLW
     ILIVQLTFTR KSFERCSHKI IELWMRSGGG DTWWRVVCRL ARSTAVMSMV GAILGLGDRH
     LDNVLVNLDK GDIVHIDYNI CFDKGKHLRV PETVPFRLTQ NIVHALGPTQ VEGVFRESCG
     HVLATLREGR EVLLTVLEAF VYDPLVDWAV ADHLTTSSAA VGVAVTLAVY VRIRESAVPW
     MNNCVELTGA LRNVMDALER QMRRDETNVW TNGEKLDQER VEAGRRLKTA IARHQHMMKD
     FRPLLRALAT VDELKTKWAH IIFHKFYLRI YDGLVGLEKK VSRPLTPSLL SQVYVIVVLF
     FLIFKNALFQ ADALIRQATS STLLAQMYEG WTAWV
//