ID   A0A1I7XEW0_HETBA        Unreviewed;       460 AA.
AC   A0A1I7XEW0;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Mitochondrial-processing peptidase subunit alpha {ECO:0000256|ARBA:ARBA00016741};
DE   AltName: Full=Alpha-MPP {ECO:0000256|ARBA:ARBA00030006};
DE   AltName: Full=Inactive zinc metalloprotease alpha {ECO:0000256|ARBA:ARBA00032315};
OS   Heterorhabditis bacteriophora (Entomopathogenic nematode).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Heterorhabditidae;
OC   Heterorhabditis.
OX   NCBI_TaxID=37862 {ECO:0000313|Proteomes:UP000095283, ECO:0000313|WBParaSite:Hba_16259};
RN   [1] {ECO:0000313|WBParaSite:Hba_16259}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- FUNCTION: Substrate recognition and binding subunit of the essential
CC       mitochondrial processing protease (MPP), which cleaves the
CC       mitochondrial sequence off newly imported precursors proteins.
CC       {ECO:0000256|ARBA:ARBA00002123}.
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DR   AlphaFoldDB; A0A1I7XEW0; -.
DR   WBParaSite; Hba_16259; Hba_16259; Hba_16259.
DR   Proteomes; UP000095283; Unplaced.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProt.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 2.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   PANTHER; PTHR11851; METALLOPROTEASE; 1.
DR   PANTHER; PTHR11851:SF49; MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 2.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   4: Predicted;
FT   DOMAIN          183..363
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
SQ   SEQUENCE   460 AA;  51607 MW;  CEC043AC450F8F17 CRC64;
     MFSRIPQCLQ MRSFCTTRIQ RAHLKDITRV PLSTPLNGDF SNKSTRSVLN HIPFDAKLSK
     LESAIRVASE VHYGEYCTIG LAIESGSRYE ASYPLGTSHL VEKLAFGSTS RHSSRDEIYE
     VLEQNGGLID CQSTRDTFIY AASCHVNGLD AIVEILANAV WRSNVTNEEV PKTFEHFIRK
     LRVGVDHNEL VKIVERHFDV NTTTWAQHPN LLLEKLPPID KSVAQYTGGE VRIEKDLSTL
     AVGTPYPNLA HVALGFEGVS YSDPDFVSFC VLQSLLGGGG SFSAGGPGKG MYTRLYTDVM
     NRCHWIYGAT AYNHSYGDAG LFCIQASSDP EQINDVLVIL LDQFIRLLRG TEKDELERAK
     IQLKSQLMMN LEIRPVMFED LARQVIGHNY RRKPQEYMEK IDSISSADIV RIAERMLAGR
     PSLVGYGDVK KLASYESLDE AVAQRKLESL VTKKKIFSWQ
//