ID   A0A1I7XJX3_HETBA        Unreviewed;       673 AA.
AC   A0A1I7XJX3;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=methionine--tRNA ligase {ECO:0000256|ARBA:ARBA00012838};
DE            EC=6.1.1.10 {ECO:0000256|ARBA:ARBA00012838};
DE   AltName: Full=Methionyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030904};
OS   Heterorhabditis bacteriophora (Entomopathogenic nematode).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Heterorhabditidae;
OC   Heterorhabditis.
OX   NCBI_TaxID=37862 {ECO:0000313|Proteomes:UP000095283, ECO:0000313|WBParaSite:Hba_18015};
RN   [1] {ECO:0000313|WBParaSite:Hba_18015}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-
CC         methionyl-tRNA(Met); Xref=Rhea:RHEA:13481, Rhea:RHEA-COMP:9667,
CC         Rhea:RHEA-COMP:9698, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:57844, ChEBI:CHEBI:78442, ChEBI:CHEBI:78530,
CC         ChEBI:CHEBI:456215; EC=6.1.1.10;
CC         Evidence={ECO:0000256|ARBA:ARBA00001234};
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000256|RuleBase:RU363039}.
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DR   AlphaFoldDB; A0A1I7XJX3; -.
DR   WBParaSite; Hba_18015; Hba_18015; Hba_18015.
DR   Proteomes; UP000095283; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004825; F:methionine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006431; P:methionyl-tRNA aminoacylation; IEA:InterPro.
DR   CDD; cd07957; Anticodon_Ia_Met; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   InterPro; IPR041872; Anticodon_Met.
DR   InterPro; IPR023458; Met-tRNA_ligase_1.
DR   InterPro; IPR014758; Met-tRNA_synth.
DR   InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth.
DR   InterPro; IPR033911; MetRS_core.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   NCBIfam; TIGR00398; metG; 1.
DR   PANTHER; PTHR45765; METHIONINE--TRNA LIGASE; 1.
DR   PANTHER; PTHR45765:SF1; METHIONINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR   Pfam; PF19303; Anticodon_3; 1.
DR   Pfam; PF09334; tRNA-synt_1g; 1.
DR   PRINTS; PR01041; TRNASYNTHMET.
DR   SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW   ECO:0000256|RuleBase:RU363039};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363039};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363039};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU363039};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW   ECO:0000256|RuleBase:RU363039}.
FT   DOMAIN          62..335
FT                   /note="Methionyl/Leucyl tRNA synthetase"
FT                   /evidence="ECO:0000259|Pfam:PF09334"
FT   DOMAIN          367..443
FT                   /note="Methionyl-tRNA synthetase anticodon-binding"
FT                   /evidence="ECO:0000259|Pfam:PF19303"
SQ   SEQUENCE   673 AA;  76168 MW;  FFCD79970961A41C CRC64;
     MRGHQTLYIC GTDEYGTATE TKALYEGVTP REVCDKYHII HKEIYDWFNI EFDHFGRTTT
     EQQTEFLADR FVTGVCPLCA YDDARGDQCD ACGKLINAID LIQPKCHVCK QEPKVRQSTH
     IFLHLDRLQV SLLDDVRKYV ETQIERSDNR WSSNAIAIVK GWIKGGLDKR CITRDLKWGT
     PVPLAEFSDK VFYVWYDAPI GYLSITKCLL GNNWVKWWKN PENVELYNFV GKDNVAFHGV
     MFPSTQIGAG DNYTIVNNLC ATEYLNYENT KFSKSRGTGV FGDAAKETGI EADVWRFYLL
     YMRPESQDTV FSWDDFALKV NSELLANLGN FVNRALSFLS NNFGGVIPEM HLTNIDVELL
     CGIQDCEEWD SLLDGVKLKD AMRVVLAMSR RGNQYMQAMQ PWVLMKGTNQ DKERAGTVIG
     VAANVSYQLS IVLHPFMPET GHKIGTPKPL FVKLDNAKIA EWKSKFGGAS NKVKKMTPVQ
     AYPHLAKNQQ QIQQLLKVAS IKFEQARALF VKNKQIELEA CISKLDKEVR AVQKELVDAE
     IAAGTIKVLF EDENIFYLVK QINVSLTDQA ASVPANRSSG SAPSTSVETL HKLDKNGGQP
     KNECNKKCRE LNNGNRIRNS ILHYNFFKFQ VWETVSEHLK VSSEGFAAWK DAPLLVNGQT
     RITAPTLRGV FVK
//